Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18990 |
Resumo: | National Institutes of Health (NIH AI 30639) |
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Carvalho, Augusto Marcelino Pedreira deAmorim, Camila FariasBarbosa, Juliana L SLago, Alexsandro Ssouza doCarvalho Filho, Edgar Marcelino2017-05-22T14:13:05Z2017-05-22T14:13:05Z2015CARVALHO, A. M. P. et al. Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis. American Journal of Tropical Medicine and Hygiene, v. 92, n. 6, p. 1173–1177, 2015.0002-9637https://www.arca.fiocruz.br/handle/icict/1899010.4269/ajtmh.14-0631National Institutes of Health (NIH AI 30639)Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilLeishmania (Viannia) braziliensis is the main causal agent of American tegumentary leishmaniasis (ATL) that may present as cutaneous, mucosal, or disseminated cutaneous leishmaniasis. The disease is highly prevalent in young males and there is a lack of studies of ATL in the elderly. Herein, we compared clinical manifestations, immunologic response, and response to antimony therapy between patients > 60 years of age (N = 58) and patients who were 21-30 years of age (N = 187). The study was performed in Corte de Pedra, Bahia, Brazil, a well-known area of L. braziliensis transmission. Cytokine production by cultured peripheral blood mononuclear cells stimulated with soluble Leishmania antigen was performed. Elderly subjects more frequently had a previous history of cutaneous leishmaniasis, large lesions, or mucosal leishmaniasis, and they were less likely to have lymphadenopathy. There was no difference regarding gender and response to therapy. Peripheral blood mononuclear cells from elderly subjects produced a similar amount of tumor necrosis factor than young patients but they produced less interferon-gamma and more interleukin-10 than young subjects. We concluded that elderly patients with cutaneous leishmaniasis should be searched for mucosal or disseminated leishmaniasis. The decreased interferon-gamma production and increase in interleukin-10 observed in elderly patients may contribute to parasite persistence and L. braziliensis infection dissemination.engAmerican Society of Tropical Medicine and HygieneLeishmaniose cutâneaLeishmania braziliensisFator de necrose tumoral alfaInterleucina-10HumanosJovem adultoLeishmaniose cutâneaLeishmania braziliensisTumor Necrosis Factor-alphaInterleukin-10HumansYoung AdultLeishmaniose cutâneaLeishmania braziliensisFator de necrose tumoral alfaInterleucina-10HumanosJovem adultoAge modifies the immunologic response and clinical presentation of American tegumentary leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
title |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
spellingShingle |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis Carvalho, Augusto Marcelino Pedreira de Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto Leishmaniose cutânea Leishmania braziliensis Tumor Necrosis Factor-alpha Interleukin-10 Humans Young Adult Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto |
title_short |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
title_full |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
title_fullStr |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
title_full_unstemmed |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
title_sort |
Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis |
author |
Carvalho, Augusto Marcelino Pedreira de |
author_facet |
Carvalho, Augusto Marcelino Pedreira de Amorim, Camila Farias Barbosa, Juliana L S Lago, Alexsandro Ssouza do Carvalho Filho, Edgar Marcelino |
author_role |
author |
author2 |
Amorim, Camila Farias Barbosa, Juliana L S Lago, Alexsandro Ssouza do Carvalho Filho, Edgar Marcelino |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Augusto Marcelino Pedreira de Amorim, Camila Farias Barbosa, Juliana L S Lago, Alexsandro Ssouza do Carvalho Filho, Edgar Marcelino |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto |
topic |
Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto Leishmaniose cutânea Leishmania braziliensis Tumor Necrosis Factor-alpha Interleukin-10 Humans Young Adult Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto |
dc.subject.en.pt_BR.fl_str_mv |
Leishmaniose cutânea Leishmania braziliensis Tumor Necrosis Factor-alpha Interleukin-10 Humans Young Adult |
dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose cutânea Leishmania braziliensis Fator de necrose tumoral alfa Interleucina-10 Humanos Jovem adulto |
description |
National Institutes of Health (NIH AI 30639) |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-05-22T14:13:05Z |
dc.date.available.fl_str_mv |
2017-05-22T14:13:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, A. M. P. et al. Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis. American Journal of Tropical Medicine and Hygiene, v. 92, n. 6, p. 1173–1177, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18990 |
dc.identifier.issn.pt_BR.fl_str_mv |
0002-9637 |
dc.identifier.doi.none.fl_str_mv |
10.4269/ajtmh.14-0631 |
identifier_str_mv |
CARVALHO, A. M. P. et al. Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis. American Journal of Tropical Medicine and Hygiene, v. 92, n. 6, p. 1173–1177, 2015. 0002-9637 10.4269/ajtmh.14-0631 |
url |
https://www.arca.fiocruz.br/handle/icict/18990 |
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eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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