Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40519 |
Resumo: | Artigo encontra-se em acesso aberto pelo editor em 25 mar 2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415665/pdf/1377-03.pdf |
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Portugal, Luciane R.Fernandes, Luciana R.Cesar, Giovana C.Santiago, Helton C.Oliveira, Dirce R.Silva, Neide M.Silva, Andrea A.Lannes-Vieira, JoseliArantes, Rosa M. E.Gazzinelli, Ricardo T.Alvarez-Leite, Jacqueline I.2020-03-25T20:27:52Z2020-03-25T20:27:52Z2004PORTUGAL, Luciane R. et al. Infection with Toxoplasma gondii Increases Atherosclerotic Lesion in ApoE-Deficient Mice. Infection and Immunity, v. 72, n. 6, p. 3571-3576, June 2004.0019-9567https://www.arca.fiocruz.br/handle/icict/4051910.1128/IAI.72.6.3571-3576.20041098-5522Artigo encontra-se em acesso aberto pelo editor em 25 mar 2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415665/pdf/1377-03.pdfUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Laboratório de Imunoparasitologia; Uberlândia, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunoparasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Toxoplasma gondii is an intracellular protozoan that elicits a potent inflammatory response during the acute phase of infection. Herein, we evaluate whether T. gondii infection alters the natural course of aortic lesions. ApoE knockout mice were infected with T. gondii, and at 5 weeks of infection, serum, feces, and liver cholesterol; aortic lesion size, cellularity, and inflammatory cytokines; and levels of serum nitrite and gamma interferon (IFN-gamma) were analyzed. Our results showed that serum cholesterol and atherogenic lipoproteins were reduced after T. gondii infection. The reduction of serum levels of total cholesterol and atherogenic lipoproteins was associated with increases in the aortic lesion area, numbers of inflammatory cells, and expression of monocyte chemoattractant protein 1 and inducible nitric oxide synthase mRNA in the site of lesions as well as elevated concentrations of IFN-gamma and nitrite in sera of T. gondii-infected animals. These results suggest that infection with T. gondii accelerates atherosclerotic development by stimulating the proinflammatory response and oxidative stress, thereby increasing the area of aortic lesion.engAmerican Society for MicrobiologyToxoplasma gondiiInfecçãoLesão ateroscleróticaRatos Deficientes em ApoEToxoplasma gondiiInfectionAtherosclerotic LesionApoE-Deficient MiceInfection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| title |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| spellingShingle |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice Portugal, Luciane R. Toxoplasma gondii Infecção Lesão aterosclerótica Ratos Deficientes em ApoE Toxoplasma gondii Infection Atherosclerotic Lesion ApoE-Deficient Mice |
| title_short |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| title_full |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| title_fullStr |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| title_full_unstemmed |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| title_sort |
Infection with Toxoplasma gondii increases atherosclerotic lesion in ApoE-deficient mice |
| author |
Portugal, Luciane R. |
| author_facet |
Portugal, Luciane R. Fernandes, Luciana R. Cesar, Giovana C. Santiago, Helton C. Oliveira, Dirce R. Silva, Neide M. Silva, Andrea A. Lannes-Vieira, Joseli Arantes, Rosa M. E. Gazzinelli, Ricardo T. Alvarez-Leite, Jacqueline I. |
| author_role |
author |
| author2 |
Fernandes, Luciana R. Cesar, Giovana C. Santiago, Helton C. Oliveira, Dirce R. Silva, Neide M. Silva, Andrea A. Lannes-Vieira, Joseli Arantes, Rosa M. E. Gazzinelli, Ricardo T. Alvarez-Leite, Jacqueline I. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Portugal, Luciane R. Fernandes, Luciana R. Cesar, Giovana C. Santiago, Helton C. Oliveira, Dirce R. Silva, Neide M. Silva, Andrea A. Lannes-Vieira, Joseli Arantes, Rosa M. E. Gazzinelli, Ricardo T. Alvarez-Leite, Jacqueline I. |
| dc.subject.other.pt_BR.fl_str_mv |
Toxoplasma gondii Infecção Lesão aterosclerótica Ratos Deficientes em ApoE |
| topic |
Toxoplasma gondii Infecção Lesão aterosclerótica Ratos Deficientes em ApoE Toxoplasma gondii Infection Atherosclerotic Lesion ApoE-Deficient Mice |
| dc.subject.en.pt_BR.fl_str_mv |
Toxoplasma gondii Infection Atherosclerotic Lesion ApoE-Deficient Mice |
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Artigo encontra-se em acesso aberto pelo editor em 25 mar 2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415665/pdf/1377-03.pdf |
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2004 |
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2004 |
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2020-03-25T20:27:52Z |
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2020-03-25T20:27:52Z |
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PORTUGAL, Luciane R. et al. Infection with Toxoplasma gondii Increases Atherosclerotic Lesion in ApoE-Deficient Mice. Infection and Immunity, v. 72, n. 6, p. 3571-3576, June 2004. |
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https://www.arca.fiocruz.br/handle/icict/40519 |
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0019-9567 |
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10.1128/IAI.72.6.3571-3576.2004 |
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1098-5522 |
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PORTUGAL, Luciane R. et al. Infection with Toxoplasma gondii Increases Atherosclerotic Lesion in ApoE-Deficient Mice. Infection and Immunity, v. 72, n. 6, p. 3571-3576, June 2004. 0019-9567 10.1128/IAI.72.6.3571-3576.2004 1098-5522 |
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American Society for Microbiology |
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American Society for Microbiology |
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