The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages

Detalhes bibliográficos
Autor(a) principal: Vojnov, Lara
Data de Publicação: 2012
Outros Autores: Martins, Mauricio A., Bean, Alexander T., Santana, Marlon G. Veloso de, Sacha, Jonah B., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Stevenson, Mario, Watkins, David I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15518
Resumo: University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
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spelling Vojnov, LaraMartins, Mauricio A.Bean, Alexander T.Santana, Marlon G. Veloso deSacha, Jonah B.Wilson, Nancy A.Bonaldo, Myrna C.Galler, RicardoStevenson, MarioWatkins, David I.2016-08-30T13:44:45Z2016-08-30T13:44:45Z2012VOJNOV. Lara; et al. The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. JOurnal of Virology, v.86, n.8, p.4682-4687, Apr. 2012.0022-538Xhttps://www.arca.fiocruz.br/handle/icict/1551810.1128/JVI.06324-111098-5514engAmerican Society for MicrobiologyMacrófagosVírus da Imunodeficiência SímiaAIDSHIVCD4 T cellssimian immunodeficiency virus (SIV)SIV-Infected MacrophagesAIDSCD8 T CellsThe majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophagesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Oregon Health Sciences University. Oregon National Primate Research Center. Vaccine and Gene Therapy Institute. Beaverton, Oregin, USA.University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.University of Miami Leonard M. Miller School of Medicine. Miami, Florida, USA.University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA / Wisconsin National Primate Research Center. Madison, Wisconsin, USA.Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8(+) T cell-mediated lysis and continue to produce virus over long periods of time.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15518/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarlon_santana_etal_IOC_2012.pdfmarlon_santana_etal_IOC_2012.pdfapplication/pdf1100597https://www.arca.fiocruz.br/bitstream/icict/15518/2/marlon_santana_etal_IOC_2012.pdf08780ab83069cd89ca478db45b5676e7MD52TEXTmarlon_santana_etal_IOC_2012.pdf.txtmarlon_santana_etal_IOC_2012.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
title The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
spellingShingle The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
Vojnov, Lara
Macrófagos
Vírus da Imunodeficiência Símia
AIDS
HIV
CD4 T cells
simian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
title_short The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
title_full The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
title_fullStr The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
title_full_unstemmed The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
title_sort The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages
author Vojnov, Lara
author_facet Vojnov, Lara
Martins, Mauricio A.
Bean, Alexander T.
Santana, Marlon G. Veloso de
Sacha, Jonah B.
Wilson, Nancy A.
Bonaldo, Myrna C.
Galler, Ricardo
Stevenson, Mario
Watkins, David I.
author_role author
author2 Martins, Mauricio A.
Bean, Alexander T.
Santana, Marlon G. Veloso de
Sacha, Jonah B.
Wilson, Nancy A.
Bonaldo, Myrna C.
Galler, Ricardo
Stevenson, Mario
Watkins, David I.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vojnov, Lara
Martins, Mauricio A.
Bean, Alexander T.
Santana, Marlon G. Veloso de
Sacha, Jonah B.
Wilson, Nancy A.
Bonaldo, Myrna C.
Galler, Ricardo
Stevenson, Mario
Watkins, David I.
dc.subject.other.pt_BR.fl_str_mv Macrófagos
Vírus da Imunodeficiência Símia
AIDS
HIV
topic Macrófagos
Vírus da Imunodeficiência Símia
AIDS
HIV
CD4 T cells
simian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
dc.subject.en.pt_BR.fl_str_mv CD4 T cells
simian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
description University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-08-30T13:44:45Z
dc.date.available.fl_str_mv 2016-08-30T13:44:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VOJNOV. Lara; et al. The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. JOurnal of Virology, v.86, n.8, p.4682-4687, Apr. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15518
dc.identifier.issn.pt_BR.fl_str_mv 0022-538X
dc.identifier.doi.none.fl_str_mv 10.1128/JVI.06324-11
dc.identifier.eissn.none.fl_str_mv 1098-5514
identifier_str_mv VOJNOV. Lara; et al. The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. JOurnal of Virology, v.86, n.8, p.4682-4687, Apr. 2012.
0022-538X
10.1128/JVI.06324-11
1098-5514
url https://www.arca.fiocruz.br/handle/icict/15518
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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