Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2800 |
Resumo: | Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas. |
id |
CRUZ_323e4793ea5f8478c1c0f3dd852f8984 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/2800 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Soares, Milena Botelho PereiraBrustolim, DanieleSantos, Luciane AmorimBellintani, Moema CortizoPaiva, F. PRibeiro, Yvone MTomassini, Therezinha Coelho BarbosaSantos, Ricardo Ribeiro dos2011-08-20T00:21:06Z2011-08-20T00:21:06Z2006SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006.1567-5769https://www.arca.fiocruz.br/handle/icict/280010.1016/j.intimp.2005.09.007Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas.Este trabalho foi financiado pelo CNPq, pelo Instituto do Milênio do Semiárido(IMSEAR-MCT) e pela FIOCRUZ (PDTIS).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPhysalis angulata is a solanaceae widely used in folk medicine in various tropical countries in the world. We have previously described that seco-steroids (physalins) purified from P. angulata are potent inhibitors of macrophage activation, blocking the production of pro-inflammatory cytokines and LPS-induced lethality. Herein we investigated the immunomodulatory activities of these substances in lymphocyte proliferation and cytokine production and in transplantation. The addition of physalins B, F or G to concanavalin A-activated splenocyte cultures induced a concentration-dependent inhibition of proliferation. Physalin B also inhibited IL-2 production by Con A-activated spleen cells. The addition of 2 Ag/ml physalin B to mixed lymphocyte reaction (MLR) caused a 100% inhibition of proliferation. More importantly, treatment of mice with physalin B, F or G prevented the rejection of allogeneic heterotopic heart transplant. Our results demonstrate the suppressive activity of physalins B, F and G in lymphocyte function and indicate the potential use of physalins as immunosuppressive agents for treatments of pathologies in which inhibition of immune responses is desired.engElsevierImunossupressãoLinfoproliferaçãoTransplantaçãoPhysalinImmunosuppressionLymphoproliferationTransplantationAnimaisProliferação de CélulasConcanavalina AFemininoRejeição de EnxertoTransplante de CoraçãoImunossupressoresInterleucina-2LinfócitosMasculinoCamundongosCamundongos Endogâmicos BALB CCamundongos Endogâmicos C3HCamundongos Endogâmicos C57BLCamundongos Endogâmicos CBAMifepristonaPhysalisSecoesteróidesBaçoPhysalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares_Brustolim_Santos_etal.pdfSoares_Brustolim_Santos_etal.pdfapplication/pdf269374https://www.arca.fiocruz.br/bitstream/icict/2800/1/Soares_Brustolim_Santos_etal.pdf8adee9d9b1610cdac8a7c64218c075dcMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2800/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSoares_Brustolim_Santos_etal.pdf.txtSoares_Brustolim_Santos_etal.pdf.txtExtracted texttext/plain23514https://www.arca.fiocruz.br/bitstream/icict/2800/5/Soares_Brustolim_Santos_etal.pdf.txt6de4fb0c5de62baebdccb88c7eb3785dMD55THUMBNAILSoares_Brustolim_Santos_etal.pdf.jpgSoares_Brustolim_Santos_etal.pdf.jpgGenerated Thumbnailimage/jpeg2021https://www.arca.fiocruz.br/bitstream/icict/2800/4/Soares_Brustolim_Santos_etal.pdf.jpg13fa04a9e91fe6d1f05c5d2090a44c56MD54icict/28002023-03-15 14:33:00.741oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
title |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
spellingShingle |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection Soares, Milena Botelho Pereira Imunossupressão Linfoproliferação Transplantação Physalin Immunosuppression Lymphoproliferation Transplantation Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço |
title_short |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
title_full |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
title_fullStr |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
title_full_unstemmed |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
title_sort |
Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection |
author |
Soares, Milena Botelho Pereira |
author_facet |
Soares, Milena Botelho Pereira Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos |
author_role |
author |
author2 |
Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Soares, Milena Botelho Pereira Brustolim, Daniele Santos, Luciane Amorim Bellintani, Moema Cortizo Paiva, F. P Ribeiro, Yvone M Tomassini, Therezinha Coelho Barbosa Santos, Ricardo Ribeiro dos |
dc.subject.other.pt_BR.fl_str_mv |
Imunossupressão Linfoproliferação Transplantação |
topic |
Imunossupressão Linfoproliferação Transplantação Physalin Immunosuppression Lymphoproliferation Transplantation Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço |
dc.subject.en.pt_BR.fl_str_mv |
Physalin Immunosuppression Lymphoproliferation Transplantation |
dc.subject.decs.pt_BR.fl_str_mv |
Animais Proliferação de Células Concanavalina A Feminino Rejeição de Enxerto Transplante de Coração Imunossupressores Interleucina-2 Linfócitos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Endogâmicos C3H Camundongos Endogâmicos C57BL Camundongos Endogâmicos CBA Mifepristona Physalis Secoesteróides Baço |
description |
Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos que gentilmente ajudaram com as análises estatísticas. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2011-08-20T00:21:06Z |
dc.date.available.fl_str_mv |
2011-08-20T00:21:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/2800 |
dc.identifier.issn.none.fl_str_mv |
1567-5769 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.intimp.2005.09.007 |
identifier_str_mv |
SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006. 1567-5769 10.1016/j.intimp.2005.09.007 |
url |
https://www.arca.fiocruz.br/handle/icict/2800 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/2800/1/Soares_Brustolim_Santos_etal.pdf https://www.arca.fiocruz.br/bitstream/icict/2800/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/2800/5/Soares_Brustolim_Santos_etal.pdf.txt https://www.arca.fiocruz.br/bitstream/icict/2800/4/Soares_Brustolim_Santos_etal.pdf.jpg |
bitstream.checksum.fl_str_mv |
8adee9d9b1610cdac8a7c64218c075dc e095249ac7cacefbfe39684dfe45e706 6de4fb0c5de62baebdccb88c7eb3785d 13fa04a9e91fe6d1f05c5d2090a44c56 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1798324890830372864 |