The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria

Detalhes bibliográficos
Autor(a) principal: Antonelli, Lis Ribeiro do Valle
Data de Publicação: 2014
Outros Autores: Leoratti, Fabiana Maria de Souza, Costa, Pedro Augusto Carvalho, Rocha, Bruno Coelho, Tada, Mauro Shugiro, Pereira, Dhelio B., Carvalho, Andrea Teixeira, Golenbock, Douglas Taylor, Gonçalves, Ricardo, Gazzinelli, Ricardo Tostes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9844
Resumo: FAPEMIG, CNPq, PAPES VI, FIOCRUZ, US National Institutes of Health,National Institute of Science and Technology for Vaccines, CAPES
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spelling Antonelli, Lis Ribeiro do ValleLeoratti, Fabiana Maria de SouzaCosta, Pedro Augusto CarvalhoRocha, Bruno CoelhoTada, Mauro ShugiroPereira, Dhelio B.Carvalho, Andrea TeixeiraGolenbock, Douglas TaylorGonçalves, RicardoGazzinelli, Ricardo Tostes2015-03-26T16:18:05Z2015-03-26T16:18:05Z2014ANTONELLI, Lis Ribeiro do Valle et al. The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria. PLoS Pathog, v.10, n. 9, p. e1004393, 2014.1553-7366https://www.arca.fiocruz.br/handle/icict/984410.1371/journal.ppat.1004393FAPEMIG, CNPq, PAPES VI, FIOCRUZ, US National Institutes of Health,National Institute of Science and Technology for Vaccines, CAPESFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Immunopatologia. Belo Horizonte, MG, BrazilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Immunopatologia. Belo Horizonte, MG, BrazilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Immunopatologia. Belo Horizonte, MG, BrazilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Immunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, BrazilCentro de Pesquisas em Medicina Tropical de Rondonia. Porto Velho, RO, BrazilCentro de Pesquisas em Medicina Tropical de Rondonia. Porto Velho, RO, BrazilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoracao. Belo Horizonte, MG, BrazilUniversity of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, United States of AmericaUniversidade Federal de Minas Gerais. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilFundacao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Immunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Bioquımica e Imunologia. Belo Horizonte, MG, BrazilInfection with Plasmodium vivax results in strong activation of monocytes, which are important components of both the systemic inflammatory response and parasite control. The overall goal of this study was to define the role of monocytes during P. vivax malaria. Here, we demonstrate that P. vivax–infected patients display significant increase in circulating monocytes, which were defined as CD14+CD162 (classical), CD14+CD16+ (inflammatory), and CD14loCD16+ (patrolling) cells. While the classical and inflammatory monocytes were found to be the primary source of pro-inflammatory cytokines, the CD16+ cells, in particular the CD14+CD16+ monocytes, expressed the highest levels of activation markers, which included chemokine receptors and adhesion molecules. Morphologically, CD14+ were distinguished from CD14lo monocytes by displaying larger and more active mitochondria. CD14+CD16+ monocytes were more efficient in phagocytizing P. vivaxinfected reticulocytes, which induced them to produce high levels of intracellular TNF-a and reactive oxygen species. Importantly, antibodies specific for ICAM-1, PECAM-1 or LFA-1 efficiently blocked the phagocytosis of infected reticulocytes by monocytes. Hence, our results provide key information on the mechanism by which CD14+CD16+ cells control parasite burden, supporting the hypothesis that they play a role in resistance to P. vivax infection.engPublic Library of ScienceThe CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalariaPlasmodium vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9844/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINAL2014_171.pdf2014_171.pdfapplication/pdf4188333https://www.arca.fiocruz.br/bitstream/icict/9844/2/2014_171.pdfe10e84a2b78e645f551187f28ad44d44MD52TEXT2014_171.pdf.txt2014_171.pdf.txtExtracted texttext/plain80759https://www.arca.fiocruz.br/bitstream/icict/9844/3/2014_171.pdf.txt129aa4c681bed20e9dd7dc1399979425MD53icict/98442019-06-19 10:12:03.407oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:12:03Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
title The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
spellingShingle The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
Antonelli, Lis Ribeiro do Valle
Malaria
Plasmodium vivax
title_short The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
title_full The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
title_fullStr The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
title_full_unstemmed The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
title_sort The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria
author Antonelli, Lis Ribeiro do Valle
author_facet Antonelli, Lis Ribeiro do Valle
Leoratti, Fabiana Maria de Souza
Costa, Pedro Augusto Carvalho
Rocha, Bruno Coelho
Tada, Mauro Shugiro
Pereira, Dhelio B.
Carvalho, Andrea Teixeira
Golenbock, Douglas Taylor
Gonçalves, Ricardo
Gazzinelli, Ricardo Tostes
author_role author
author2 Leoratti, Fabiana Maria de Souza
Costa, Pedro Augusto Carvalho
Rocha, Bruno Coelho
Tada, Mauro Shugiro
Pereira, Dhelio B.
Carvalho, Andrea Teixeira
Golenbock, Douglas Taylor
Gonçalves, Ricardo
Gazzinelli, Ricardo Tostes
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antonelli, Lis Ribeiro do Valle
Leoratti, Fabiana Maria de Souza
Costa, Pedro Augusto Carvalho
Rocha, Bruno Coelho
Tada, Mauro Shugiro
Pereira, Dhelio B.
Carvalho, Andrea Teixeira
Golenbock, Douglas Taylor
Gonçalves, Ricardo
Gazzinelli, Ricardo Tostes
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium vivax
topic Malaria
Plasmodium vivax
description FAPEMIG, CNPq, PAPES VI, FIOCRUZ, US National Institutes of Health,National Institute of Science and Technology for Vaccines, CAPES
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-26T16:18:05Z
dc.date.available.fl_str_mv 2015-03-26T16:18:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANTONELLI, Lis Ribeiro do Valle et al. The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria. PLoS Pathog, v.10, n. 9, p. e1004393, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9844
dc.identifier.issn.none.fl_str_mv 1553-7366
dc.identifier.doi.none.fl_str_mv 10.1371/journal.ppat.1004393
identifier_str_mv ANTONELLI, Lis Ribeiro do Valle et al. The CD14+CD16+ Inflammatory Monocyte Subset Displays Increased Mitochondrial Activity and Effector Function During Acute Plasmodium vivax Malaria. PLoS Pathog, v.10, n. 9, p. e1004393, 2014.
1553-7366
10.1371/journal.ppat.1004393
url https://www.arca.fiocruz.br/handle/icict/9844
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/9844/1/license.txt
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