Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.

Detalhes bibliográficos
Autor(a) principal: Carvalho Filho, Edgar Marcelino
Data de Publicação: 2001
Outros Autores: Bacellar, Maria Olívia Amado Ramos, Porto, Maria Aurélia da Fonseca, Braga, Silvane, Castro Filho, Bernardo Galvão, Neva, Franklin A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8148
Resumo: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
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spelling Carvalho Filho, Edgar MarcelinoBacellar, Maria Olívia Amado RamosPorto, Maria Aurélia da FonsecaBraga, SilvaneCastro Filho, Bernardo GalvãoNeva, Franklin A2014-08-07T13:02:14Z2014-08-07T13:02:14Z2001CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001.1525-4135https://www.arca.fiocruz.br/handle/icict/8148engLippincott Williams & WilkinsCytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, USAThe modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-gamma (IFN-gamma) and the role of exogenous interleukin (IL)-10 in downregulating IFN-gamma production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-gamma, tumor necrosis factor-alpha, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-gamma production, although at high concentrations (100 ng/ml), IL-10 decreased IFN-gamma production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-gamma production in these patients.Cellular immunity in HTLV-1Citokines in HTLV-1HTLV-1Immune response in HTLV-1Immunomodulation in HTLV-1Doadores de SangueCitocinas/biossínteseInfecções por HTLV-I/imunologiaVírus 1 Linfotrópico T Humano/imunologiaAdultoLinfócitos T CD4-Positivos/imunologiaFemininoAnticorpos Anti-HTLV-I/sangueHumanosInterferon gama/biossínteseCélulas Matadoras Naturais/imunologiaMasculinoMeia-Idadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCarvalho EM Cytokine Profile....pdfCarvalho EM Cytokine Profile....pdfapplication/pdf4020404https://www.arca.fiocruz.br/bitstream/icict/8148/1/Carvalho%20EM%20Cytokine%20Profile....pdf7c293e1e23c5998c1a26e3bf86849c6fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8148/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCarvalho EM Cytokine Profile....pdf.txtCarvalho EM Cytokine Profile....pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/8148/3/Carvalho%20EM%20Cytokine%20Profile....pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD53icict/81482023-03-15 14:33:11.176oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
title Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
spellingShingle Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
Carvalho Filho, Edgar Marcelino
Cellular immunity in HTLV-1
Citokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
Doadores de Sangue
Citocinas/biossíntese
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Adulto
Linfócitos T CD4-Positivos/imunologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Humanos
Interferon gama/biossíntese
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
title_short Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
title_full Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
title_fullStr Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
title_full_unstemmed Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
title_sort Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors.
author Carvalho Filho, Edgar Marcelino
author_facet Carvalho Filho, Edgar Marcelino
Bacellar, Maria Olívia Amado Ramos
Porto, Maria Aurélia da Fonseca
Braga, Silvane
Castro Filho, Bernardo Galvão
Neva, Franklin A
author_role author
author2 Bacellar, Maria Olívia Amado Ramos
Porto, Maria Aurélia da Fonseca
Braga, Silvane
Castro Filho, Bernardo Galvão
Neva, Franklin A
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho Filho, Edgar Marcelino
Bacellar, Maria Olívia Amado Ramos
Porto, Maria Aurélia da Fonseca
Braga, Silvane
Castro Filho, Bernardo Galvão
Neva, Franklin A
dc.subject.en.pt_BR.fl_str_mv Cellular immunity in HTLV-1
Citokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
topic Cellular immunity in HTLV-1
Citokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
Doadores de Sangue
Citocinas/biossíntese
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Adulto
Linfócitos T CD4-Positivos/imunologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Humanos
Interferon gama/biossíntese
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
dc.subject.decs.pt_BR.fl_str_mv Doadores de Sangue
Citocinas/biossíntese
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Adulto
Linfócitos T CD4-Positivos/imunologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Humanos
Interferon gama/biossíntese
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
description Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2014-08-07T13:02:14Z
dc.date.available.fl_str_mv 2014-08-07T13:02:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8148
dc.identifier.issn.none.fl_str_mv 1525-4135
identifier_str_mv CARVALHO FILHO, E. M. et al. Cytokine profile and immunomodulation in asymptomatic human T-lymphotropic virus type 1-infected blood donors. Journal of Acquired Immune Deficiency Syndromes, v. 27, n. 1, p. 1-6, 2001.
1525-4135
url https://www.arca.fiocruz.br/handle/icict/8148
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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