Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23125 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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Nicol, Alcina F.Tugizov, Sharof M.Herrera, RossanaGrinsztejn, BeatrizFriedman, Ruth K.Veloso, Valdiléa G.Cunha, Cynthia B.Chein A.Wechsler, Erin IsaacsonCosta, Maria daPalefsky, Joel M.2017-11-13T14:05:08Z2017-11-13T14:05:08Z2017NICOL, Alcina F. etal. Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia. International Journal of Clinical and Experimental Pathology, v. 10, n. 6, p. 6946-6955, 2017.1936-2625https://www.arca.fiocruz.br/handle/icict/23125enge-Century PublishingHPVHIV-1Claudin-1Displasia AnalHomens que Fazem Sexo com HomensMulheresHPVHIV-1Claudin-1Anal DysplasiaMen Who Have Sex With MenWomenPapillomaviridaeHIV-1Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.University of California. Department of Medicine. San Francisco, CA, USA.University of California. Department of Medicine. San Francisco, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ. Brasil.University of California. Department of Medicine. San Francisco, CA, USA.University of California. Department of Medicine. San Francisco, CA, USA.University of California. Department of Medicine. San Francisco, CA, USA.University of California. Department of Medicine. San Francisco, CA, USA.Background: Claudin-1 expression is poorly characterized in anal intraepithelial neoplasia (AIN) from HIVpositive individuals. Aim: To investigate claudin-1 in situ expression in HPV-positive AIN lesions from HIV-positive individuals compared with non-dysplastic anal tissues. Materials and Methods: By means of immunofluorescence microscopy, claudin-1 was analyzed in 46 anal tissues: 18 AIN1; 14 AIN2/3 and 14 non-dysplastic specimens. Results: A higher proportion of cells with overexpression of claudin-1 were found in HIV-positive AIN lesions compared with controls. Overexpression of claudin-1 was most evident in AIN 2/3 lesions. HPV16 was detected in 21.8% anal specimens and HPV18 in 3.1%. A great diversity of 18 low-risk HPV types were detected, 40% of AIN specimens had multiple HPV types. Conclusions: Our data show that there is an over-expression of claudin-1 in HIV-positive AIN lesions compared with non-dysplastic anal biopsies. A high prevalence of HPV16 and diversity of HPV types was detected. The overexpression of claudin-1 in HIV-positive AIN specimens may play a role on the development of anal cancer, however further studies should be performed to better understand the role of claudin-1 in AIN and anal cancer development in the HIV-positive individuals.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83080https://www.arca.fiocruz.br/bitstream/icict/23125/1/license.txtc0ab280de860857c9554497e24a9070dMD51ORIGINALNicol_Alcina_F_etal_IOC_2017.pdfNicol_Alcina_F_etal_IOC_2017.pdfapplication/pdf1039575https://www.arca.fiocruz.br/bitstream/icict/23125/2/Nicol_Alcina_F_etal_IOC_2017.pdf1ba1845ab78d47b6a5b46a310ead62f5MD52TEXTNicol_Alcina_F_etal_IOC_2017.pdf.txtNicol_Alcina_F_etal_IOC_2017.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| title |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| spellingShingle |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia Nicol, Alcina F. HPV HIV-1 Claudin-1 Displasia Anal Homens que Fazem Sexo com Homens Mulheres HPV HIV-1 Claudin-1 Anal Dysplasia Men Who Have Sex With Men Women Papillomaviridae HIV-1 |
| title_short |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| title_full |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| title_fullStr |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| title_full_unstemmed |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| title_sort |
Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia |
| author |
Nicol, Alcina F. |
| author_facet |
Nicol, Alcina F. Tugizov, Sharof M. Herrera, Rossana Grinsztejn, Beatriz Friedman, Ruth K. Veloso, Valdiléa G. Cunha, Cynthia B. Chein A. Wechsler, Erin Isaacson Costa, Maria da Palefsky, Joel M. |
| author_role |
author |
| author2 |
Tugizov, Sharof M. Herrera, Rossana Grinsztejn, Beatriz Friedman, Ruth K. Veloso, Valdiléa G. Cunha, Cynthia B. Chein A. Wechsler, Erin Isaacson Costa, Maria da Palefsky, Joel M. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nicol, Alcina F. Tugizov, Sharof M. Herrera, Rossana Grinsztejn, Beatriz Friedman, Ruth K. Veloso, Valdiléa G. Cunha, Cynthia B. Chein A. Wechsler, Erin Isaacson Costa, Maria da Palefsky, Joel M. |
| dc.subject.other.pt_BR.fl_str_mv |
HPV HIV-1 Claudin-1 Displasia Anal Homens que Fazem Sexo com Homens Mulheres |
| topic |
HPV HIV-1 Claudin-1 Displasia Anal Homens que Fazem Sexo com Homens Mulheres HPV HIV-1 Claudin-1 Anal Dysplasia Men Who Have Sex With Men Women Papillomaviridae HIV-1 |
| dc.subject.en.pt_BR.fl_str_mv |
HPV HIV-1 Claudin-1 Anal Dysplasia Men Who Have Sex With Men Women |
| dc.subject.decs.pt_BR.fl_str_mv |
Papillomaviridae HIV-1 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-11-13T14:05:08Z |
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2017-11-13T14:05:08Z |
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2017 |
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NICOL, Alcina F. etal. Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia. International Journal of Clinical and Experimental Pathology, v. 10, n. 6, p. 6946-6955, 2017. |
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https://www.arca.fiocruz.br/handle/icict/23125 |
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1936-2625 |
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NICOL, Alcina F. etal. Claudin-1 expression in HIV/HPV co-infected anal intra-epithelial neoplasia. International Journal of Clinical and Experimental Pathology, v. 10, n. 6, p. 6946-6955, 2017. 1936-2625 |
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