Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30442 |
Resumo: | Instituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil. |
| id |
CRUZ_44362839af60992d28c7270201861ad8 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/30442 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Braggio, EstebanBraggio, Danielle de AlmeidaSmall, Isabele ÁvilaLopes, Lisandro F.Valadão, MarcusGouveia, Maria EmmerickMoreira, Aline dos SantosLinhares, EduardoRomano, SérgioBacchi, Carlos E.Renault, Ilana ZalchergGuimarães, Denise PeixotoFerreira, Carlos Gil2018-12-08T20:04:17Z2018-12-08T20:04:17Z2010BRAGGIO, Esteban; et al. Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors. Anticancer Research, v.30, p.2407-2414, 2010.0250-7005https://www.arca.fiocruz.br/handle/icict/304421791-7530engInternational Institute of Anticancer ResearchRelevância prognósticatumores estromais gastrointestinaismutações do KIT e PDGFRAGastrointestinal Stromal TumorsmutationsPrognostic RelevanceKIT and PDGFRA mutationsPrognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Consultoria em Patologia. Botucatu, SP, Brasil.Instituto Nacional de Câncer. Serviço de Cirurgia Abdominal-pélvica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional de Bioinformática. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Serviço de Cirurgia Abdominal-pélvica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Patologia. Rio de Janeiro, RJ, Brasil.Consultoria em Patologia. Botucatu, SP, Brasil.Instituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Divisão de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Background: Prediction of biological behavior is crucial for selection of new therapeutic modalities in GIST. Here, we aimed to assess whether KIT and PDGFRA mutations have survival impact in gastrointestinal stromal tumors (GIST). Patients and Methods: Fifty-five Brazilian patients with completely resected GIST were examined for KIT and PDGFRA mutations. The 5-year disease-free survival (DFS) was analyzed. Results: KIT and PDGFRA mutations were identified in 74.5% and 7.3% of patients, respectively. The 5-year DFS rate for all patients was 52.8%. The 5-year DFS rate was lower in patients with tumors having inframe deletions or concomitant in-frame deletions and insertions affecting codons 557-558 than in patients with tumors having other exon 11 KIT mutations (p=0.023). Conversely, when the patients with concomitant deletioninsertion mutations affecting codons 557-558 were excluded from the analysis, deletions involving codons 557-558 had no influence on 5-year DFS rates. Conclusion: Our findings indicate that a specific KIT mutation may be associated with unfavorable behavior in GIST. This finding may have implications on selecting patients for adjuvant therapy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30442/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalines_moreira_etal_IOC_2010.pdfalines_moreira_etal_IOC_2010.pdfapplication/pdf211669https://www.arca.fiocruz.br/bitstream/icict/30442/2/alines_moreira_etal_IOC_2010.pdf328237a1369059808b2fce6b45e30253MD52TEXTalines_moreira_etal_IOC_2010.pdf.txtalines_moreira_etal_IOC_2010.pdf.txtExtracted texttext/plain31154https://www.arca.fiocruz.br/bitstream/icict/30442/3/alines_moreira_etal_IOC_2010.pdf.txt0b48809f26cc0088c62cde902b8c2c33MD53icict/304422018-12-09 02:01:24.901oai:www.arca.fiocruz.br:icict/30442Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-12-09T04:01:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| title |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| spellingShingle |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors Braggio, Esteban Relevância prognóstica tumores estromais gastrointestinais mutações do KIT e PDGFRA Gastrointestinal Stromal Tumors mutations Prognostic Relevance KIT and PDGFRA mutations |
| title_short |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| title_full |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| title_fullStr |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| title_full_unstemmed |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| title_sort |
Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors |
| author |
Braggio, Esteban |
| author_facet |
Braggio, Esteban Braggio, Danielle de Almeida Small, Isabele Ávila Lopes, Lisandro F. Valadão, Marcus Gouveia, Maria Emmerick Moreira, Aline dos Santos Linhares, Eduardo Romano, Sérgio Bacchi, Carlos E. Renault, Ilana Zalcherg Guimarães, Denise Peixoto Ferreira, Carlos Gil |
| author_role |
author |
| author2 |
Braggio, Danielle de Almeida Small, Isabele Ávila Lopes, Lisandro F. Valadão, Marcus Gouveia, Maria Emmerick Moreira, Aline dos Santos Linhares, Eduardo Romano, Sérgio Bacchi, Carlos E. Renault, Ilana Zalcherg Guimarães, Denise Peixoto Ferreira, Carlos Gil |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Braggio, Esteban Braggio, Danielle de Almeida Small, Isabele Ávila Lopes, Lisandro F. Valadão, Marcus Gouveia, Maria Emmerick Moreira, Aline dos Santos Linhares, Eduardo Romano, Sérgio Bacchi, Carlos E. Renault, Ilana Zalcherg Guimarães, Denise Peixoto Ferreira, Carlos Gil |
| dc.subject.other.pt_BR.fl_str_mv |
Relevância prognóstica tumores estromais gastrointestinais mutações do KIT e PDGFRA |
| topic |
Relevância prognóstica tumores estromais gastrointestinais mutações do KIT e PDGFRA Gastrointestinal Stromal Tumors mutations Prognostic Relevance KIT and PDGFRA mutations |
| dc.subject.en.pt_BR.fl_str_mv |
Gastrointestinal Stromal Tumors mutations Prognostic Relevance KIT and PDGFRA mutations |
| description |
Instituto Nacional de Câncer. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
| dc.date.accessioned.fl_str_mv |
2018-12-08T20:04:17Z |
| dc.date.available.fl_str_mv |
2018-12-08T20:04:17Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
BRAGGIO, Esteban; et al. Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors. Anticancer Research, v.30, p.2407-2414, 2010. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30442 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0250-7005 |
| dc.identifier.eissn.none.fl_str_mv |
1791-7530 |
| identifier_str_mv |
BRAGGIO, Esteban; et al. Prognostic Relevance of KITand PDGFRAMutations in Gastrointestinal Stromal Tumors. Anticancer Research, v.30, p.2407-2414, 2010. 0250-7005 1791-7530 |
| url |
https://www.arca.fiocruz.br/handle/icict/30442 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
International Institute of Anticancer Research |
| publisher.none.fl_str_mv |
International Institute of Anticancer Research |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/30442/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/30442/2/alines_moreira_etal_IOC_2010.pdf https://www.arca.fiocruz.br/bitstream/icict/30442/3/alines_moreira_etal_IOC_2010.pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 328237a1369059808b2fce6b45e30253 0b48809f26cc0088c62cde902b8c2c33 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1794075737977782272 |