Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Pacheco, A. G.
Data de Publicação: 2014
Outros Autores: Veloso, V. G., Nunes, E. P., Ribeiro, S., Guimarães, M. R. C., Lourenço, M. C., Mello, F. C. Q., Grinsztejn, Beatriz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27724
Resumo: Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
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spelling Pacheco, A. G.Veloso, V. G.Nunes, E. P.Ribeiro, S.Guimarães, M. R. C.Lourenço, M. C.Mello, F. C. Q.Grinsztejn, Beatriz2018-07-30T18:38:17Z2018-07-30T18:38:17Z2014PACHECO, A. D. et al. Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro. International Journal of Tuberculosis and Lung Disease, v. 18, n. 12, p. 1473-1478, 2014.1027-3719https://www.arca.fiocruz.br/handle/icict/2772410.5588/ijtld.14.0181engTuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Doenças do Torax. Rio de Janeiro, Rio de Janeiro, RJ, Brasil.SETTING: Human immunodeficiency virus (HIV) infected patients followed in a large cohort in Rio de Janeiro, Brazil. OBJECTIVE: To evaluate the association of tuberculosis (TB) and other covariables with non-TB-related (NTR) causes of death (CODs). DESIGN: Patients aged .18 years were followed from 1997 to 2009, until death or 31 December 2009, whichever was earlier. CODs were ascertained using a standardised algorithm. TB diagnosis and prophylaxis followed Brazilian guidelines. Poisson models were used to calculate adjusted rate ratios (aRRs). RESULTS: Of 2887 patients included in the study, 761 had TB (26.4%). NTR death rates were twice as high among patients with TB (4/100 vs. 2.09/100 patientyears). TB was associated with NTR deaths (aRR 1.4, 95%CI 1.05–1.86, P ¼ 0.01). Highly active antiretroviral treatment (HAART) was protective against NTR (aRR 0.46, 95%CI 0.34–0.61, P , 0.001). Among patients who had never had active TB, prophylaxis was also protective against NTR (aRR 0.45, P ¼ 0.04). The CD4 cell count increase was very modest for both TB and NTR CODs compared to those who did not die (0 vs. 249 cells, P , 0.001). CONCLUSIONS: TB was significantly associated with increased NTR CODs, indicating rapid progression of disease and increased long-term risk of mortality, probably related to persistent immunodeficiency or incomplete immune recovery. Our results confirm the benefits of HAART and TB prophylaxis.CohortAntiretroviral therapyMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/27724/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALTuberculosis is associated with non-tuberculosis-related deaths among_Valdilea_Veloso_etal_INI_Lapclin_2014.pdfTuberculosis is associated with non-tuberculosis-related deaths among_Valdilea_Veloso_etal_INI_Lapclin_2014.pdfapplication/pdf92649https://www.arca.fiocruz.br/bitstream/icict/27724/2/Tuberculosis%20is%20associated%20with%20non-tuberculosis-related%20deaths%20among_Valdilea_Veloso_etal_INI_Lapclin_2014.pdf3173e97be1a9b9f2f86fccfd5a82495dMD52TEXTTuberculosis is associated with non-tuberculosis-related deaths among_Valdilea_Veloso_etal_INI_Lapclin_2014.pdf.txtTuberculosis is 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dc.title.pt_BR.fl_str_mv Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
title Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
spellingShingle Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
Pacheco, A. G.
Cohort
Antiretroviral therapy
Mortality
title_short Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
title_full Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
title_fullStr Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
title_full_unstemmed Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
title_sort Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro
author Pacheco, A. G.
author_facet Pacheco, A. G.
Veloso, V. G.
Nunes, E. P.
Ribeiro, S.
Guimarães, M. R. C.
Lourenço, M. C.
Mello, F. C. Q.
Grinsztejn, Beatriz
author_role author
author2 Veloso, V. G.
Nunes, E. P.
Ribeiro, S.
Guimarães, M. R. C.
Lourenço, M. C.
Mello, F. C. Q.
Grinsztejn, Beatriz
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pacheco, A. G.
Veloso, V. G.
Nunes, E. P.
Ribeiro, S.
Guimarães, M. R. C.
Lourenço, M. C.
Mello, F. C. Q.
Grinsztejn, Beatriz
dc.subject.en.pt_BR.fl_str_mv Cohort
Antiretroviral therapy
Mortality
topic Cohort
Antiretroviral therapy
Mortality
description Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-07-30T18:38:17Z
dc.date.available.fl_str_mv 2018-07-30T18:38:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PACHECO, A. D. et al. Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro. International Journal of Tuberculosis and Lung Disease, v. 18, n. 12, p. 1473-1478, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27724
dc.identifier.issn.pt_BR.fl_str_mv 1027-3719
dc.identifier.doi.none.fl_str_mv 10.5588/ijtld.14.0181
identifier_str_mv PACHECO, A. D. et al. Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro. International Journal of Tuberculosis and Lung Disease, v. 18, n. 12, p. 1473-1478, 2014.
1027-3719
10.5588/ijtld.14.0181
url https://www.arca.fiocruz.br/handle/icict/27724
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27724/1/license.txt
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