Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Gois, Luana Leandro
Data de Publicação: 2013
Outros Autores: Mehta, Sanjay, Schooley, Robert T, Badaró, Roberto José da Silva, Grassi, Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8477
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
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spelling Gois, Luana LeandroMehta, SanjaySchooley, Robert TBadaró, Roberto José da SilvaGrassi, Maria Fernanda Rios2014-09-30T19:15:08Z2014-09-30T19:15:08Z2013GÓIS, L. L. et al. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 1, p. 9-14, 2014.0074-0276,https://www.arca.fiocruz.br/handle/icict/847710.1590/0074-0276130174porFiocruzDecreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of California San Diego. La Jolla, CA, USAUniversity of California San Diego. La Jolla, CA, USAUniversity of California San Diego. La Jolla, CA, USA / 3Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilThe effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated. This study quantified and evaluated the function of memory T-cell subsets in response to soluble Leishmania antigens (SLA) from patients coinfected with HIV and Leishmania with tegumentary leishmaniasis (TL). Eight TL/HIV coinfected subjects and 10 HIV seronegative subjects with TL were evaluated. The proliferative response of CD4+ and CD8+ T-cells and naïve, central memory (CM) and effector memory (EM) CD4+ T-cells in response to SLA were quantified using flow cytometry. The median cell division indices for CD4+ and CD8+ T-cells of coinfected patients in response to SLA were significantly lower than those in patients with Leishmania monoinfection (p < 0.05). The proportions of CM and EM CD4+ T-cells in response to SLA were similar between the coinfected patients and patients with Leishmania monoinfection. However, the median CM and EM CD4+ T-cell counts from coinfected patients were significantly lower (p < 0.05). The reduction in the lymphoproliferative response to Leishmania antigens coincides with the decrease in the absolute numbers of both EM and CM CD4+ T-cells in response to Leishmania antigens in patients coinfected with HIV/LeishmaniaLeishmaniaHIVCoinfectionMemory CD4+ T-cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8477/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALGois L L Decreased memory....pdfGois L L Decreased memory....pdfapplication/pdf340802https://www.arca.fiocruz.br/bitstream/icict/8477/2/Gois%20L%20L%20Decreased%20memory....pdfbb27642815473cd88d3ce095c5e95ab6MD52TEXTGois L L Decreased memory....pdf.txtGois L L Decreased memory....pdf.txtExtracted texttext/plain27957https://www.arca.fiocruz.br/bitstream/icict/8477/3/Gois%20L%20L%20Decreased%20memory....pdf.txtfb850f8856838faaed29ca17d940c0a8MD53icict/84772023-03-15 14:33:01.683oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
title Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
spellingShingle Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
Gois, Luana Leandro
Leishmania
HIV
Coinfection
Memory CD4+ T-cells
title_short Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
title_full Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
title_fullStr Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
title_full_unstemmed Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
title_sort Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
author Gois, Luana Leandro
author_facet Gois, Luana Leandro
Mehta, Sanjay
Schooley, Robert T
Badaró, Roberto José da Silva
Grassi, Maria Fernanda Rios
author_role author
author2 Mehta, Sanjay
Schooley, Robert T
Badaró, Roberto José da Silva
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gois, Luana Leandro
Mehta, Sanjay
Schooley, Robert T
Badaró, Roberto José da Silva
Grassi, Maria Fernanda Rios
dc.subject.en.pt_BR.fl_str_mv Leishmania
HIV
Coinfection
Memory CD4+ T-cells
topic Leishmania
HIV
Coinfection
Memory CD4+ T-cells
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-30T19:15:08Z
dc.date.available.fl_str_mv 2014-09-30T19:15:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GÓIS, L. L. et al. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 1, p. 9-14, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8477
dc.identifier.issn.none.fl_str_mv 0074-0276,
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276130174
identifier_str_mv GÓIS, L. L. et al. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis. Memórias do Instituto Oswaldo Cruz, v. 109, n. 1, p. 9-14, 2014.
0074-0276,
10.1590/0074-0276130174
url https://www.arca.fiocruz.br/handle/icict/8477
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz
publisher.none.fl_str_mv Fiocruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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