SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021

Detalhes bibliográficos
Autor(a) principal: Nonaka, Carolina Kymie Vasques
Data de Publicação: 2021
Outros Autores: Gräf, Tiago, Barcia, Camila Araújo de Lorenzo, Costa, Vanessa Ferreira, Oliveira, Janderson Lopes de, Passos, Rogério da Hora, Bastos, Iasmin Nogueira, Santana, Maria Clara Brito de, Santos, Ian Marinho, Sousa, Karoline Almeida Felix de, Weber, Thamires Gomes Lopes, Siqueira, Isadora Cristina de, Rocha, Clarissa Araújo Gurgel, Mendes, Ana Verena Almeida, Souza, Bruno Solano de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50679
Resumo: This study was funded by CNPq, Inova Fiocruz, the Serrapilheira Institute, and the D’Or Institute for Research and Education. Ethics statement This study was reviewed by local IRBs and received ethical approval by the National Committee for Ethics on Research (CONEP; CAAE: 29496920.8.0000.5262, 46821621.5.0000.0048 and 3.980.128 /2020). All sampled patients have provided written informed consent.
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spelling Nonaka, Carolina Kymie VasquesGräf, TiagoBarcia, Camila Araújo de LorenzoCosta, Vanessa FerreiraOliveira, Janderson Lopes dePassos, Rogério da HoraBastos, Iasmin NogueiraSantana, Maria Clara Brito deSantos, Ian MarinhoSousa, Karoline Almeida Felix deWeber, Thamires Gomes LopesSiqueira, Isadora Cristina deRocha, Clarissa Araújo GurgelMendes, Ana Verena AlmeidaSouza, Bruno Solano de Freitas2022-01-07T21:07:02Z2022-01-07T21:07:02Z2021NONAKA, Carolina Kymie Vasques et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021. International Journal of Infectious Diseases, v. 111, p. 47-54, 2021.1201-9712https://www.arca.fiocruz.br/handle/icict/5067910.1016/j.ijid.2021.08.003This study was funded by CNPq, Inova Fiocruz, the Serrapilheira Institute, and the D’Or Institute for Research and Education. Ethics statement This study was reviewed by local IRBs and received ethical approval by the National Committee for Ethics on Research (CONEP; CAAE: 29496920.8.0000.5262, 46821621.5.0000.0048 and 3.980.128 /2020). All sampled patients have provided written informed consent.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D'Or Institute for Research and Education (IDOR). Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.São Rafael Hospital. Clinical Laboratory. Salvador, BA, Brazil.Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Oswaldo Cruz Foundation. Gonçalo Moniz Institute. Salvador, BA, Brazil.Objectives: To evaluate changes in the characteristics of patients with coronavirus disease 2019 (COVID-19) after the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) P.1 (Gamma), by comparing the clinical, demographic, and laboratory profiles of patients hospitalized during the first (May to July 2020) and second (December 2020 to February 2021) pandemic waves. Methods: Data were collected from the records of COVID-19 patients (n = 4164) admitted to a single hospital in Salvador, Northeast Brazil. SARS-CoV-2 genome sequencing was performed on nasopharyngeal swab samples from 12 patients aged <60 years admitted to the intensive care unit (ICU) in February 2021. Results: Between June 2020 and February 2021, the median age of patients admitted to the ICU decreased from 66 to 58 years (P < 0.05). This was accompanied by an increased proportion of patients without comorbidities (15.32% vs 32.20%, P < 0.0001). A significant reduction in the cycle threshold values of SARS-CoV-2 RT-PCR tests was observed in the second wave (P < 0.0001). Sequencing analysis detected lineage Gamma in all 12 ICU patients sampled in February 2021. Conclusions: The results of this study demonstrated an increased proportion of younger adults without comorbidities with severe disease during the second COVID-19 wave, shortly after the confirmation of local Gamma circulation.engElsevierhttps://www.arca.fiocruz.br/handle/icict/48692SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19SARS-CoV-2Variants of concernP.1Gammainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
title SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
spellingShingle SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
Nonaka, Carolina Kymie Vasques
COVID-19
SARS-CoV-2
Variants of concern
P.1
Gamma
title_short SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
title_full SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
title_fullStr SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
title_full_unstemmed SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
title_sort SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, Northeast Brazil, February 2021
author Nonaka, Carolina Kymie Vasques
author_facet Nonaka, Carolina Kymie Vasques
Gräf, Tiago
Barcia, Camila Araújo de Lorenzo
Costa, Vanessa Ferreira
Oliveira, Janderson Lopes de
Passos, Rogério da Hora
Bastos, Iasmin Nogueira
Santana, Maria Clara Brito de
Santos, Ian Marinho
Sousa, Karoline Almeida Felix de
Weber, Thamires Gomes Lopes
Siqueira, Isadora Cristina de
Rocha, Clarissa Araújo Gurgel
Mendes, Ana Verena Almeida
Souza, Bruno Solano de Freitas
author_role author
author2 Gräf, Tiago
Barcia, Camila Araújo de Lorenzo
Costa, Vanessa Ferreira
Oliveira, Janderson Lopes de
Passos, Rogério da Hora
Bastos, Iasmin Nogueira
Santana, Maria Clara Brito de
Santos, Ian Marinho
Sousa, Karoline Almeida Felix de
Weber, Thamires Gomes Lopes
Siqueira, Isadora Cristina de
Rocha, Clarissa Araújo Gurgel
Mendes, Ana Verena Almeida
Souza, Bruno Solano de Freitas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nonaka, Carolina Kymie Vasques
Gräf, Tiago
Barcia, Camila Araújo de Lorenzo
Costa, Vanessa Ferreira
Oliveira, Janderson Lopes de
Passos, Rogério da Hora
Bastos, Iasmin Nogueira
Santana, Maria Clara Brito de
Santos, Ian Marinho
Sousa, Karoline Almeida Felix de
Weber, Thamires Gomes Lopes
Siqueira, Isadora Cristina de
Rocha, Clarissa Araújo Gurgel
Mendes, Ana Verena Almeida
Souza, Bruno Solano de Freitas
dc.subject.en.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Variants of concern
P.1
Gamma
topic COVID-19
SARS-CoV-2
Variants of concern
P.1
Gamma
description This study was funded by CNPq, Inova Fiocruz, the Serrapilheira Institute, and the D’Or Institute for Research and Education. Ethics statement This study was reviewed by local IRBs and received ethical approval by the National Committee for Ethics on Research (CONEP; CAAE: 29496920.8.0000.5262, 46821621.5.0000.0048 and 3.980.128 /2020). All sampled patients have provided written informed consent.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-07T21:07:02Z
dc.date.available.fl_str_mv 2022-01-07T21:07:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv NONAKA, Carolina Kymie Vasques et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021. International Journal of Infectious Diseases, v. 111, p. 47-54, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50679
dc.identifier.issn.pt_BR.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2021.08.003
identifier_str_mv NONAKA, Carolina Kymie Vasques et al. SARS-CoV-2 variant of concern P.1 (Gamma) infection in young and middle-aged patients admitted to the intensive care units of a single hospital in Salvador, northeast Brazil, February 2021. International Journal of Infectious Diseases, v. 111, p. 47-54, 2021.
1201-9712
10.1016/j.ijid.2021.08.003
url https://www.arca.fiocruz.br/handle/icict/50679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.isversionof.pt_BR.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48692
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/50679/2/Nonaka_Carolina_etal_IGM_COVID-19_ARTIGO_FINAL.pdf
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