Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series

Bibliographic Details
Main Author: Silva, Fabio Luis
Publication Date: 2023
Other Authors: Menegueti, Mayra Gonçalves, Sato, Lucas, Peres, Leandro Moreira, Sepeda, Corina dos Reis, Petroski-Moraes, Bruno C., Donadel, Mariana Dermínio, Gallo, Gabriela Bortoleto, Jordani, Maria Cecília, Mestriner, Fabiola, Becari, Christiane, Basile Filho, Anibal, Evora, Paulo Roberto Barbosa, Martins Filho, Olindo Assis, Martins, Maria Auxiliadora
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/57338
Summary: Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.
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spelling Silva, Fabio LuisMenegueti, Mayra GonçalvesSato, LucasPeres, Leandro MoreiraSepeda, Corina dos ReisPetroski-Moraes, Bruno C.Donadel, Mariana DermínioGallo, Gabriela BortoletoJordani, Maria CecíliaMestriner, FabiolaBecari, ChristianeBasile Filho, AnibalEvora, Paulo Roberto BarbosaMartins Filho, Olindo AssisMartins, Maria Auxiliadora2023-03-13T17:33:44Z2023-03-13T17:33:44Z2023SILVA, Fabio Luis et al. Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series. Medicine, v. 102, n. 4, p. 1-7, Jan. 2023.0025-7974https://www.arca.fiocruz.br/handle/icict/5733810.1097/MD.0000000000032743engLippincott Williams & WilkinsEffect of methylene blue on hemodynamic response in the early phase of septic shock: a case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDivision of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Ribeirão Preto Nursing School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Cardiac Surgery. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo.Ribeirão Preto, SP, Brazil.Division of Vascular and Endovascular Surgery. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Vascular and Endovascular Surgery. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Division of Cardiac Surgery. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo.Ribeirão Preto, SP, Brazil.Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil.Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Rationale: Methylene blue (MB) has been used to increase blood pressure in septic shock, acting on the activity of guanylate cyclase and nitric oxide synthase. Patience concerns: The aim of this study is to demonstrate the benefit of MB in early phase of septic shock. Diagnoses: We report 6 cases of patients with septic shock with up to 72 hours of evolution. Interventions: We used MB after fluid replacement, use of norepinephrine and vasopressin. Patients received a loading dose of MB and maintenance for 48 hours. Outcomes: All patients presented a reduction in the dose of vasopressors and lactate levels soon after the administration of the loading dose of MB, an effect that was maintained with the maintenance dose for 48 hours. Interleukin 6 and interleukin 8 were elevated at the beginning of the septic condition, with a progressive and marked reduction after the beginning of MB infusion, demonstrating a role of MB in reducing the inflammatory activity. Lessons: This case series suggests that MB used early in the treatment of septic shock may be useful in reducing vasopressor dose and lactate levels. Further studies are still required to further validate these findings. Abbreviations: cGMP = cyclic guanosine monophosphate, CO = cardiac output, ICU = intensive care unit, IL = interleukin, MAP = mean arterial pressure, MB = methylene blue, NO = nitric oxide, NO3 = serum nitrate, sGC = soluble guanylyl cyclase, T = time, TNF-alfa = tumor necrosis fator.CytokinesMethylene blue (MB)Nitric oxideSeptic Shockinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57338/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeffect of methylene blue.pdfeffect of methylene blue.pdfapplication/pdf988178https://www.arca.fiocruz.br/bitstream/icict/57338/2/effect%20of%20methylene%20blue.pdf8990ea698aea583a5b159d58b34a10e0MD52icict/573382023-05-26 23:44:40.293oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
title Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
spellingShingle Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
Silva, Fabio Luis
Cytokines
Methylene blue (MB)
Nitric oxide
Septic Shock
title_short Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
title_full Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
title_fullStr Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
title_full_unstemmed Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
title_sort Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series
author Silva, Fabio Luis
author_facet Silva, Fabio Luis
Menegueti, Mayra Gonçalves
Sato, Lucas
Peres, Leandro Moreira
Sepeda, Corina dos Reis
Petroski-Moraes, Bruno C.
Donadel, Mariana Dermínio
Gallo, Gabriela Bortoleto
Jordani, Maria Cecília
Mestriner, Fabiola
Becari, Christiane
Basile Filho, Anibal
Evora, Paulo Roberto Barbosa
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
author_role author
author2 Menegueti, Mayra Gonçalves
Sato, Lucas
Peres, Leandro Moreira
Sepeda, Corina dos Reis
Petroski-Moraes, Bruno C.
Donadel, Mariana Dermínio
Gallo, Gabriela Bortoleto
Jordani, Maria Cecília
Mestriner, Fabiola
Becari, Christiane
Basile Filho, Anibal
Evora, Paulo Roberto Barbosa
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Fabio Luis
Menegueti, Mayra Gonçalves
Sato, Lucas
Peres, Leandro Moreira
Sepeda, Corina dos Reis
Petroski-Moraes, Bruno C.
Donadel, Mariana Dermínio
Gallo, Gabriela Bortoleto
Jordani, Maria Cecília
Mestriner, Fabiola
Becari, Christiane
Basile Filho, Anibal
Evora, Paulo Roberto Barbosa
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
dc.subject.en.en_US.fl_str_mv Cytokines
Methylene blue (MB)
Nitric oxide
Septic Shock
topic Cytokines
Methylene blue (MB)
Nitric oxide
Septic Shock
description Division of Intensive Care Medicine. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-13T17:33:44Z
dc.date.available.fl_str_mv 2023-03-13T17:33:44Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Fabio Luis et al. Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series. Medicine, v. 102, n. 4, p. 1-7, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57338
dc.identifier.issn.en_US.fl_str_mv 0025-7974
dc.identifier.doi.none.fl_str_mv 10.1097/MD.0000000000032743
identifier_str_mv SILVA, Fabio Luis et al. Effect of methylene blue on hemodynamic response in the early phase of septic shock: a case series. Medicine, v. 102, n. 4, p. 1-7, Jan. 2023.
0025-7974
10.1097/MD.0000000000032743
url https://www.arca.fiocruz.br/handle/icict/57338
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57338/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57338/2/effect%20of%20methylene%20blue.pdf
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bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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