Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,

Detalhes bibliográficos
Autor(a) principal: Gonçalves-Ferri, Walusa Assad
Data de Publicação: 2022
Outros Autores: Albuquerque, Agnes Afrodite Sumarelli, Castro, Renata Sayuri Ansai Pereira de, Ferreira, Cristina Helena Faleiros, Oharomari Jr., Luis K., Lessa, Diego Fernando Silva, Evora, Paulo Roberto Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/213592
Resumo: Objective: The authors design an animal model of neonatal sepsis to analyze the treatment of neonatal septic shock with Methylene Blue (MB) in a swine model. Methods: The study design included twenty male newborn pigs divided into four groups: 1) The control group; 2) The sepsis group (induced with lipopolysaccharide); 3) The MB group, and 4) The MB-treated sepsis group. Septic shock was defined as Blood Pressure (BP) dropping 20% below the baseline value. Continuous Blood Pressure (BP), Nitric Oxide (NO) levels, cyclic Guanosine Monophosphate (cGMP), malondialdehyde acid, base excess, lactate, arterial blood gases, hematocrit, and echocardiography were analyzed. Results: The BP of the sepsis group treated with MB showed a slight improvement in the first hour after treatment; however, a significant difference was not observed compared to the untreated sepsis group. Besides hemodynamic stability, the current study did not show symptomatic pulmonary hypertension, suggesting that MB was safe in neonates and children. An improvement in Base Excel (BE) levels after MB administration in septic animals may indicate a possible improvement in microcirculation. Conclusion: The MB improved biomarkers related to septic shock prognosis, although an improvement in the blood levels could not be detected. MB might be a beneficial drug for hemodynamic instability in infants.
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spelling Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,Methylene blueSeptic shockVasoplegic syndromeNitric oxideInfantsNewbornObjective: The authors design an animal model of neonatal sepsis to analyze the treatment of neonatal septic shock with Methylene Blue (MB) in a swine model. Methods: The study design included twenty male newborn pigs divided into four groups: 1) The control group; 2) The sepsis group (induced with lipopolysaccharide); 3) The MB group, and 4) The MB-treated sepsis group. Septic shock was defined as Blood Pressure (BP) dropping 20% below the baseline value. Continuous Blood Pressure (BP), Nitric Oxide (NO) levels, cyclic Guanosine Monophosphate (cGMP), malondialdehyde acid, base excess, lactate, arterial blood gases, hematocrit, and echocardiography were analyzed. Results: The BP of the sepsis group treated with MB showed a slight improvement in the first hour after treatment; however, a significant difference was not observed compared to the untreated sepsis group. Besides hemodynamic stability, the current study did not show symptomatic pulmonary hypertension, suggesting that MB was safe in neonates and children. An improvement in Base Excel (BE) levels after MB administration in septic animals may indicate a possible improvement in microcirculation. Conclusion: The MB improved biomarkers related to septic shock prognosis, although an improvement in the blood levels could not be detected. MB might be a beneficial drug for hemodynamic instability in infants.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-11-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21359210.1016/j.clinsp.2022.100139Clinics; Vol. 77 (2022); 100139Clinics; v. 77 (2022); 100139Clinics; Vol. 77 (2022); 1001391980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213592/195677Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessGonçalves-Ferri, Walusa AssadAlbuquerque, Agnes Afrodite SumarelliCastro, Renata Sayuri Ansai Pereira deFerreira, Cristina Helena FaleirosOharomari Jr., Luis K.Lessa, Diego Fernando SilvaEvora, Paulo Roberto Barbosa2023-07-06T13:05:00Zoai:revistas.usp.br:article/213592Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:05Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
title Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
spellingShingle Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
Gonçalves-Ferri, Walusa Assad
Methylene blue
Septic shock
Vasoplegic syndrome
Nitric oxide
Infants
Newborn
title_short Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
title_full Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
title_fullStr Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
title_full_unstemmed Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
title_sort Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
author Gonçalves-Ferri, Walusa Assad
author_facet Gonçalves-Ferri, Walusa Assad
Albuquerque, Agnes Afrodite Sumarelli
Castro, Renata Sayuri Ansai Pereira de
Ferreira, Cristina Helena Faleiros
Oharomari Jr., Luis K.
Lessa, Diego Fernando Silva
Evora, Paulo Roberto Barbosa
author_role author
author2 Albuquerque, Agnes Afrodite Sumarelli
Castro, Renata Sayuri Ansai Pereira de
Ferreira, Cristina Helena Faleiros
Oharomari Jr., Luis K.
Lessa, Diego Fernando Silva
Evora, Paulo Roberto Barbosa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves-Ferri, Walusa Assad
Albuquerque, Agnes Afrodite Sumarelli
Castro, Renata Sayuri Ansai Pereira de
Ferreira, Cristina Helena Faleiros
Oharomari Jr., Luis K.
Lessa, Diego Fernando Silva
Evora, Paulo Roberto Barbosa
dc.subject.por.fl_str_mv Methylene blue
Septic shock
Vasoplegic syndrome
Nitric oxide
Infants
Newborn
topic Methylene blue
Septic shock
Vasoplegic syndrome
Nitric oxide
Infants
Newborn
description Objective: The authors design an animal model of neonatal sepsis to analyze the treatment of neonatal septic shock with Methylene Blue (MB) in a swine model. Methods: The study design included twenty male newborn pigs divided into four groups: 1) The control group; 2) The sepsis group (induced with lipopolysaccharide); 3) The MB group, and 4) The MB-treated sepsis group. Septic shock was defined as Blood Pressure (BP) dropping 20% below the baseline value. Continuous Blood Pressure (BP), Nitric Oxide (NO) levels, cyclic Guanosine Monophosphate (cGMP), malondialdehyde acid, base excess, lactate, arterial blood gases, hematocrit, and echocardiography were analyzed. Results: The BP of the sepsis group treated with MB showed a slight improvement in the first hour after treatment; however, a significant difference was not observed compared to the untreated sepsis group. Besides hemodynamic stability, the current study did not show symptomatic pulmonary hypertension, suggesting that MB was safe in neonates and children. An improvement in Base Excel (BE) levels after MB administration in septic animals may indicate a possible improvement in microcirculation. Conclusion: The MB improved biomarkers related to septic shock prognosis, although an improvement in the blood levels could not be detected. MB might be a beneficial drug for hemodynamic instability in infants.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-24
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213592
10.1016/j.clinsp.2022.100139
url https://www.revistas.usp.br/clinics/article/view/213592
identifier_str_mv 10.1016/j.clinsp.2022.100139
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213592/195677
dc.rights.driver.fl_str_mv Copyright (c) 2023 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 77 (2022); 100139
Clinics; v. 77 (2022); 100139
Clinics; Vol. 77 (2022); 100139
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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