The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review

Detalhes bibliográficos
Autor(a) principal: Cubillos-Angulo, Juan Manuel
Data de Publicação: 2021
Outros Autores: Fernandes, Catarina D., Araújo, Davi N., Carmo, Cristinna A., Arriaga Gutiérrez, María Belen, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48004
Resumo: Research Program of the Fundação Oswaldo Cruz, Brazil. BBA is a senior investigator of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). JMC-A was supported by the Organization of American States–Partnerships Program for Education and Training (OAS-PAEC), and his study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brazil (CAPE S)–Finance Code 001. MBA and CDF received research fellowships from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). DNA and CAC received research fellowships from CNPq.
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spelling Cubillos-Angulo, Juan ManuelFernandes, Catarina D.Araújo, Davi N.Carmo, Cristinna A.Arriaga Gutiérrez, María BelenAndrade, Bruno de Bezerril2021-07-06T12:29:13Z2021-07-06T12:29:13Z2021CUBILLOS-ANGULO, Juan Manuel et al. The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review. Systematic Reviews, 2021.2046-4053https://www.arca.fiocruz.br/handle/icict/4800410.1186/s13643-021-01729-yResearch Program of the Fundação Oswaldo Cruz, Brazil. BBA is a senior investigator of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). JMC-A was supported by the Organization of American States–Partnerships Program for Education and Training (OAS-PAEC), and his study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brazil (CAPE S)–Finance Code 001. MBA and CDF received research fellowships from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). DNA and CAC received research fellowships from CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Division of Infectious Diseases. Department of Medicine. Nashville, TN, USA / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa.Tuberculosis (TB) is still one of the leading causes of death worldwide. Genetic studies have pointed to the relevance of the NOD2 and CD14 polymorphic alleles in association with the risk of diseases caused by Mycobacterium tuberculosis (Mtb) infection. Methods: A systematic review was performed on PubMed, EMBASE, Scientific Electronic Library Online (SciELO), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) to examine the association between single nucleotide polymorphisms (SNP) and risk of Mtb diseases. Study quality was evaluated using the Newcastle- Ottawa Quality Scale (NOQS), and the linkage disequilibrium was calculated for all SNPs using a webtool (Package LDpop). Results: Thirteen studies matched the selection criteria. Of those, 9 investigated CD14 SNPs, and 6 reported a significant association between the T allele and TT genotypes of the rs2569190 SNP and increased risk of Mtb diseases. The genotype CC was found to be protective against TB disease. Furthermore, in two studies, the CD14 rs2569191 SNP with the G allele was significantly associated with increased risk of Mtb diseases. Four studies reported data uncovering the relationship between NOD2 SNPs and risk of Mtb diseases, with two reporting significant associations of rs1861759 and rs7194886 and higher risk of Mtb diseases in a Chinese Han population. Paradoxically, minor allele carriers (CG or GG) of rs2066842 and rs2066844 NOD2 SNPs were associated with lower risk of Mtb diseases in African Americans. Conclusions: The CD14 rs2569190 and rs2569191 polymorphisms may influence risk of Mtb diseases depending on the allele. Furthermore, there is significant association between NOD2 SNPs rs1861759 and rs7194886 and augmented risk of Mtb diseases, especially in persons of Chinese ethnicity. The referred polymorphisms of CD14 and NOD2 genes likely play an important role in risk of Mtb diseases and pathology and may be affected by ethnicity.engBMCMycobacterium tuberculosisPolimorfismo de nucleotídeo únicoTuberculoseRevisão SistemáticaNOD2CD14Single nucleotide polymorphismTuberculosisThe influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48004/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCubilos-Angulo, Juan M. 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dc.title.pt_BR.fl_str_mv The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
title The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
spellingShingle The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
Cubillos-Angulo, Juan Manuel
Mycobacterium tuberculosis
Polimorfismo de nucleotídeo único
Tuberculose
Revisão Sistemática
NOD2
CD14
Single nucleotide polymorphism
Tuberculosis
title_short The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
title_full The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
title_fullStr The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
title_full_unstemmed The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
title_sort The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review
author Cubillos-Angulo, Juan Manuel
author_facet Cubillos-Angulo, Juan Manuel
Fernandes, Catarina D.
Araújo, Davi N.
Carmo, Cristinna A.
Arriaga Gutiérrez, María Belen
Andrade, Bruno de Bezerril
author_role author
author2 Fernandes, Catarina D.
Araújo, Davi N.
Carmo, Cristinna A.
Arriaga Gutiérrez, María Belen
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cubillos-Angulo, Juan Manuel
Fernandes, Catarina D.
Araújo, Davi N.
Carmo, Cristinna A.
Arriaga Gutiérrez, María Belen
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Mycobacterium tuberculosis
Polimorfismo de nucleotídeo único
Tuberculose
Revisão Sistemática
topic Mycobacterium tuberculosis
Polimorfismo de nucleotídeo único
Tuberculose
Revisão Sistemática
NOD2
CD14
Single nucleotide polymorphism
Tuberculosis
dc.subject.en.pt_BR.fl_str_mv NOD2
CD14
Single nucleotide polymorphism
Tuberculosis
description Research Program of the Fundação Oswaldo Cruz, Brazil. BBA is a senior investigator of the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). JMC-A was supported by the Organization of American States–Partnerships Program for Education and Training (OAS-PAEC), and his study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brazil (CAPE S)–Finance Code 001. MBA and CDF received research fellowships from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). DNA and CAC received research fellowships from CNPq.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-06T12:29:13Z
dc.date.available.fl_str_mv 2021-07-06T12:29:13Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv CUBILLOS-ANGULO, Juan Manuel et al. The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review. Systematic Reviews, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48004
dc.identifier.issn.pt_BR.fl_str_mv 2046-4053
dc.identifier.doi.none.fl_str_mv 10.1186/s13643-021-01729-y
identifier_str_mv CUBILLOS-ANGULO, Juan Manuel et al. The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review. Systematic Reviews, 2021.
2046-4053
10.1186/s13643-021-01729-y
url https://www.arca.fiocruz.br/handle/icict/48004
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