Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population

Detalhes bibliográficos
Autor(a) principal: Milano, Mariana
Data de Publicação: 2016
Outros Autores: Moraes, Milton Ozório, Rodenbusch, Rodrigo, Carvalho, Caroline Xavier, Delcroix, Melaine, Mousquer, Gabriel, Costa, Lucas Laux da, Unis, Gisela, Dalla Costa, Elis Regina, Rossetti, Maria Lucia Rosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/17771
Resumo: Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Biologia Celular e Molecular. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.
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spelling Milano, MarianaMoraes, Milton OzórioRodenbusch, RodrigoCarvalho, Caroline XavierDelcroix, MelaineMousquer, GabrielCosta, Lucas Laux daUnis, GiselaDalla Costa, Elis ReginaRossetti, Maria Lucia Rosa2017-02-09T15:31:06Z2017-02-09T15:31:06Z2016MILANO, Mariana; et al. Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. PLoS ONE, v.11, n.2, e0147, 11p, Feb. 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1777110.1371/journal.pone.0147814engPublic Library of ScienceTuberculose PulmonarSul do BrasilPolimorfismos de nucleotídeo únicoMycobacterium tuberculosisPulmonary TuberculosisSingle Nucleotide PolymorphismsSouthern Brazilian populationMycobacterium tuberculosisSingle Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Biologia Celular e Molecular. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.University of California.Division of Infectious Disease and Vaccinology. Berkeley, CA, USA.Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Clínica Médica. Rio de Janeiro, RJ, Brasil.Hospital Sanatório Partenon. Porto Alegre, RS, Brasil.Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, BrasilUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Biologia Celular e Molecular. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil / Universidade Luterana do Brasil. Canoas, RS, Brasil.In Mycobacterium tuberculosis (MTB) infection, the complex interaction of host immune system and the mycobacteria is associated with levels of cytokines production that play a major role in determining the outcome of the disease. Several single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with tuberculosis (TB) outcome. The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility. We conducted a case-control study in individuals from Southern Brazil who were recruited between February 2012 and October 2013 in a high incidence TB city. We performed a multiplex genotyping assay in 191 patients with PTB and 175 healthy subjects. Our results suggest a decreased risk for PTB development associated with the IL17A -197A allele (OR = 0.29; p = 0.04), AA genotype (OR = 0.12; p = 0.04) and A carrier (AG/AA) (OR = 0.29; p = 0.004) and IL6 -174C carrier (CC/CG) (OR = 0.46; p = 0.04). We could not properly analyze IL17A -692 C>T (rs8193036) and IFNG +874T>A due to genotypic inconsistencies and found no evidence of association for the IL2, IL4, IL10 and TNF polymorphisms and PTB. In conclusion, our results show a protective effect of IL17 and IL6 polymorphisms on PTB outcome in Southern Brazilian population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17771/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmilton2_moraes_eta_IOC_2016.pdfmilton2_moraes_eta_IOC_2016.pdfapplication/pdf275009https://www.arca.fiocruz.br/bitstream/icict/17771/2/milton2_moraes_eta_IOC_2016.pdf0e5da130f7534c7658222a349633047eMD52TEXTmilton2_moraes_eta_IOC_2016.pdf.txtmilton2_moraes_eta_IOC_2016.pdf.txtExtracted texttext/plain43145https://www.arca.fiocruz.br/bitstream/icict/17771/3/milton2_moraes_eta_IOC_2016.pdf.txt1e491f2d56631e0fe640d72ea3071115MD53icict/177712018-08-15 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dc.title.pt_BR.fl_str_mv Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
title Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
spellingShingle Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
Milano, Mariana
Tuberculose Pulmonar
Sul do Brasil
Polimorfismos de nucleotídeo único
Mycobacterium tuberculosis
Pulmonary Tuberculosis
Single Nucleotide Polymorphisms
Southern Brazilian population
Mycobacterium tuberculosis
title_short Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
title_full Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
title_fullStr Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
title_full_unstemmed Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
title_sort Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population
author Milano, Mariana
author_facet Milano, Mariana
Moraes, Milton Ozório
Rodenbusch, Rodrigo
Carvalho, Caroline Xavier
Delcroix, Melaine
Mousquer, Gabriel
Costa, Lucas Laux da
Unis, Gisela
Dalla Costa, Elis Regina
Rossetti, Maria Lucia Rosa
author_role author
author2 Moraes, Milton Ozório
Rodenbusch, Rodrigo
Carvalho, Caroline Xavier
Delcroix, Melaine
Mousquer, Gabriel
Costa, Lucas Laux da
Unis, Gisela
Dalla Costa, Elis Regina
Rossetti, Maria Lucia Rosa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Milano, Mariana
Moraes, Milton Ozório
Rodenbusch, Rodrigo
Carvalho, Caroline Xavier
Delcroix, Melaine
Mousquer, Gabriel
Costa, Lucas Laux da
Unis, Gisela
Dalla Costa, Elis Regina
Rossetti, Maria Lucia Rosa
dc.subject.other.pt_BR.fl_str_mv Tuberculose Pulmonar
Sul do Brasil
Polimorfismos de nucleotídeo único
Mycobacterium tuberculosis
topic Tuberculose Pulmonar
Sul do Brasil
Polimorfismos de nucleotídeo único
Mycobacterium tuberculosis
Pulmonary Tuberculosis
Single Nucleotide Polymorphisms
Southern Brazilian population
Mycobacterium tuberculosis
dc.subject.en.pt_BR.fl_str_mv Pulmonary Tuberculosis
Single Nucleotide Polymorphisms
Southern Brazilian population
Mycobacterium tuberculosis
description Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Biologia Celular e Molecular. Porto Alegre, RS, Brasil / Fundação Estadual de Produção e Pesquisa em Saúde. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-02-09T15:31:06Z
dc.date.available.fl_str_mv 2017-02-09T15:31:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MILANO, Mariana; et al. Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. PLoS ONE, v.11, n.2, e0147, 11p, Feb. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/17771
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0147814
identifier_str_mv MILANO, Mariana; et al. Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. PLoS ONE, v.11, n.2, e0147, 11p, Feb. 2016.
1932-6203
10.1371/journal.pone.0147814
url https://www.arca.fiocruz.br/handle/icict/17771
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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