Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2015
Outros Autores: Andrade, Bruno de Bezerril, Souza, Ligia C L, Magalhães, Belisa Maria Lopes, Mourão, Maria Paula Gomes, Lacerda, Marcus Vinícius Guimarães de, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13976
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
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spelling Mendonça, Vitor Rosa Ramos deAndrade, Bruno de BezerrilSouza, Ligia C LMagalhães, Belisa Maria LopesMourão, Maria Paula GomesLacerda, Marcus Vinícius Guimarães deBarral Netto, Manoel2016-04-26T17:32:23Z2016-04-26T17:32:23Z2015MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015.1475-2875https://www.arca.fiocruz.br/handle/icict/1397610.1186/s12936-015-0835-8engBioMed CentralUnravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, BrasilBackground: Concurrent malaria and dengue infection is frequently diagnosed in endemic countries, but its immunopathology remains largely unknown. In the present study, a large panel of cytokines/chemokines and clinical laboratory markers were measured in patients with Plasmodium vivax and dengue co-infection as well as in individuals with malaria or dengue mono-infections in order to identify biosignatures of each clinical condition. Methods: Individuals from the Brazilian Amazon were recruited between 2009 and 2013 and classified in three groups: vivax malaria (n = 52), dengue (n = 30) and vivax malaria and dengue co-infection (n = 30). P. vivax malaria was diagnosed by thick blood smear and confirmed by PCR; dengue cases were detected by IgM ELISA or NS1 protein. The plasma levels of cytokines and chemokines were determined by multiplex assay. Results: Individuals with malaria and dengue co-infection displayed lower levels of platelets and haemoglobin than those with malaria or dengue mono-infections (p = 0.0047 and p = 0.0001, respectively). The group of individuals coinfected exhibited the highest median concentrations of IFN-γ, IL-6, CCL4 than the mono-infected groups. Network analyses of plasma cytokines/chemokines revealed that malaria and dengue co-infection exhibits a distinct immune profile with critical roles for TNF, IL-6 and IFN-γ. Further, parasitaemia levels displayed positive significant interactions with IL-6, CCL4 and IL-10 in the group of patients co-infected with malaria and dengue. No differences were observed in distribution of dengue virus serotypes and Plasmodium parasitaemia levels between the groups. Conclusions: The findings described here identify unique patterns of circulating immunological markers in cases of malaria and dengue co-infection and provide insights on the immunopathology of this co-morbid condition.Immune responseCo-infectionDenguePlasmodium vivaxMalariainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13976/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMendonça VRR Unravelling the....pdfMendonça VRR Unravelling the....pdfapplication/pdf1769522https://www.arca.fiocruz.br/bitstream/icict/13976/2/Mendon%c3%a7a%20VRR%20Unravelling%20the....pdf9e588aa167adfadd6783622be1f69634MD52TEXTMendonça VRR Unravelling the....pdf.txtMendonça VRR Unravelling the....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
title Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
spellingShingle Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
Mendonça, Vitor Rosa Ramos de
Immune response
Co-infection
Dengue
Plasmodium vivax
Malaria
title_short Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
title_full Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
title_fullStr Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
title_full_unstemmed Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
title_sort Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Andrade, Bruno de Bezerril
Souza, Ligia C L
Magalhães, Belisa Maria Lopes
Mourão, Maria Paula Gomes
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
author_role author
author2 Andrade, Bruno de Bezerril
Souza, Ligia C L
Magalhães, Belisa Maria Lopes
Mourão, Maria Paula Gomes
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Andrade, Bruno de Bezerril
Souza, Ligia C L
Magalhães, Belisa Maria Lopes
Mourão, Maria Paula Gomes
Lacerda, Marcus Vinícius Guimarães de
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Immune response
Co-infection
Dengue
Plasmodium vivax
Malaria
topic Immune response
Co-infection
Dengue
Plasmodium vivax
Malaria
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiogia e Imunoregulação. LIMI. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-26T17:32:23Z
dc.date.available.fl_str_mv 2016-04-26T17:32:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13976
dc.identifier.issn.none.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-015-0835-8
identifier_str_mv MENDONÇA, V. R. R. et al. Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co‑infection. Malaria Journal, v. 14, p. 315, 2015.
1475-2875
10.1186/s12936-015-0835-8
url https://www.arca.fiocruz.br/handle/icict/13976
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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