Networking the host immune response in Plasmodium vivax malaria

Detalhes bibliográficos
Autor(a) principal: Mendonça, Vitor Rosa Ramos de
Data de Publicação: 2013
Outros Autores: Queiroz, Artur Trancoso Lopo de, Lopes, Fabrício M., Andrade, Bruno de Bezerril, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7259
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
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spelling Mendonça, Vitor Rosa Ramos deQueiroz, Artur Trancoso Lopo deLopes, Fabrício M.Andrade, Bruno de BezerrilBarral Netto, Manoel2013-11-25T17:21:54Z2013-11-25T17:21:54Z2013MENDONÇA, V. R. R. et al. Networking the host immune response in Plasmodium vivax malaria. Malaria Journal (Online), v.12, p. 69-78, 2013.1475-2875https://www.arca.fiocruz.br/handle/icict/7259doi:10.1186/1475-2875-12-69engBioMed Central LtdNetworking the host immune response in Plasmodium vivax malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade de São Paulo. Instituto de Matemática e Estatística. São Paulo, SP, Brasil / Universidade Tecnológica Federal do Paraná. Coordenação de Informática. Cornélio Procópio, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, MD, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, BrasilBackground: Plasmodium vivax malaria clinical outcomes are a consequence of the interaction of multiple parasite, environmental and host factors. The host molecular and genetic determinants driving susceptibility to disease severity in this infection are largely unknown. Here, a network analysis of large-scale data from a significant number of individuals with different clinical presentations of P. vivax malaria was performed in an attempt to identify patterns of association between various candidate biomarkers and the clinical outcomes. Methods: A retrospective analysis of 530 individuals from the Brazilian Amazon, including P. vivax-infected individuals who developed different clinical outcomes (148 asymptomatic malaria, 187 symptomatic malaria, 13 severe non-lethal malaria, and six severe lethal malaria) as well as 176 non-infected controls, was performed. Plasma levels of liver transaminases, bilirubins, creatinine, fibrinogen, C-reactive protein, superoxide dismutase (SOD)-1, haem oxygenase (HO)-1 and a panel composed by multiple cytokines and chemokines were measured and compared between the different clinical groups using network analysis. Results: Non-infected individuals displayed several statistically significant interactions in the networks, including associations between the levels of IL-10 and IL-4 with the chemokine CXCL9. Individuals with asymptomatic malaria displayed multiple significant interactions involving IL-4. Subjects with mild or severe non-lethal malaria displayed substantial loss of interactions in the networks and TNF had significant associations more frequently with other parameters. Cases of lethal P. vivax malaria infection were associated with significant interactions between TNF ALT, HO-1 and SOD-1. Conclusions: The findings imply that clinical immunity to P. vivax malaria is associated with multiple significant interactions in the network, mostly involving IL-4, while lethality is linked to a systematic reduction of complexity of these interactions and to an increase in connections between markers linked to haemolysis-induced damage.MalariaPlasmodium vivaxBiomarkersNetwork analysisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMendonça Vitor RR Networking the host....pdfMendonça Vitor RR Networking the host....pdfapplication/pdf537180https://www.arca.fiocruz.br/bitstream/icict/7259/1/Mendon%c3%a7a%20Vitor%20RR%20Networking%20the%20host....pdff779ebf4192be14c04b483489e271c97MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7259/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMendonça Vitor RR Networking the host....pdf.txtMendonça Vitor RR Networking the host....pdf.txtExtracted texttext/plain51139https://www.arca.fiocruz.br/bitstream/icict/7259/5/Mendon%c3%a7a%20Vitor%20RR%20Networking%20the%20host....pdf.txt2b9d26cac85d5e435691d259883d30d4MD55THUMBNAILMendonça Vitor RR Networking the host....pdf.jpgMendonça Vitor RR Networking the host....pdf.jpgGenerated Thumbnailimage/jpeg2599https://www.arca.fiocruz.br/bitstream/icict/7259/4/Mendon%c3%a7a%20Vitor%20RR%20Networking%20the%20host....pdf.jpgdab3e57d33a16fcb15e361cd459a7bdcMD54icict/72592023-03-15 14:33:12.351oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Networking the host immune response in Plasmodium vivax malaria
title Networking the host immune response in Plasmodium vivax malaria
spellingShingle Networking the host immune response in Plasmodium vivax malaria
Mendonça, Vitor Rosa Ramos de
Malaria
Plasmodium vivax
Biomarkers
Network analysis
title_short Networking the host immune response in Plasmodium vivax malaria
title_full Networking the host immune response in Plasmodium vivax malaria
title_fullStr Networking the host immune response in Plasmodium vivax malaria
title_full_unstemmed Networking the host immune response in Plasmodium vivax malaria
title_sort Networking the host immune response in Plasmodium vivax malaria
author Mendonça, Vitor Rosa Ramos de
author_facet Mendonça, Vitor Rosa Ramos de
Queiroz, Artur Trancoso Lopo de
Lopes, Fabrício M.
Andrade, Bruno de Bezerril
Barral Netto, Manoel
author_role author
author2 Queiroz, Artur Trancoso Lopo de
Lopes, Fabrício M.
Andrade, Bruno de Bezerril
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mendonça, Vitor Rosa Ramos de
Queiroz, Artur Trancoso Lopo de
Lopes, Fabrício M.
Andrade, Bruno de Bezerril
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Malaria
Plasmodium vivax
Biomarkers
Network analysis
topic Malaria
Plasmodium vivax
Biomarkers
Network analysis
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-25T17:21:54Z
dc.date.available.fl_str_mv 2013-11-25T17:21:54Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDONÇA, V. R. R. et al. Networking the host immune response in Plasmodium vivax malaria. Malaria Journal (Online), v.12, p. 69-78, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7259
dc.identifier.issn.none.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv doi:10.1186/1475-2875-12-69
identifier_str_mv MENDONÇA, V. R. R. et al. Networking the host immune response in Plasmodium vivax malaria. Malaria Journal (Online), v.12, p. 69-78, 2013.
1475-2875
doi:10.1186/1475-2875-12-69
url https://www.arca.fiocruz.br/handle/icict/7259
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central Ltd
publisher.none.fl_str_mv BioMed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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