Mice rescued from severe malaria are protected against renal injury during a second kidney insult
| Main Author: | |
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| Publication Date: | 2014 |
| Other Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/59384 |
Summary: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil. |
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Abreu, Thiago P.Silva, Leandro S.Takiya, Christina M.Souza, Mariana C.Henriques, Maria G.Pinheiro, Ana Acacia S.Caruso-Neves, Celso2023-07-03T22:13:08Z2023-07-03T22:13:08Z2014ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/5938410.1371/JOURNAL.PONE.00936341932-6203engPublic Library of ScienceAcute Kidney InjuryAnimalsAntimalarialsCollagenDisease Models, AnimalKidney CortexKidney GlomerulusMalariaMaleMiceParasitemiaPlasmodium bergheiProtective AgentsMalariaPlasmodium falciparumSepsisRenal injuryMiceSecond kidney insultMice rescued from severe malaria are protected against renal injury during a second kidney insultinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos - Farmanguinhos. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos - Farmanguinhos. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional Para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasília, DF, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional Para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasília, DF, Brazil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Malaria is a worldwide disease that leads to 1 million deaths per year. Plasmodium falciparum is the species responsible for the most severe form of malaria leading to different complications. Beyond the development of cerebral malaria, impairment of renal function is a mortality indicator in infected patients. Treatment with antimalarial drugs can increase survival, however the long-term effects of malaria on renal disease, even after treatment with antimalarials, are unknown. The aim of this study was to evaluate the effect of antimalarial drug treatment on renal function in a murine model of severe malaria and then evaluate kidney susceptibility to a second renal insult. Initially, mice infected with Plasmodium berghei ANKA achieved 20% parasitemia on day 5 post infection, which was completely abolished after treatment with 25 mg/kg artesunate and 40 mg/kg mefloquine. The treatment also decreased plasma creatinine levels by 43% and partially reversed the reduction in the glomerular filtration rate induced by infection. The urinary protein/creatinine ratio, collagen deposition, and size of the interstitial space decreased by 75%, 40%, and 20%, respectively, with drugs compared with untreated infected animals. In infected-treated mice that underwent a second renal insult, the plasma creatinine level decreased by 60% and the glomerular filtration rate increased compared with infected animals treated only with antimalarials. The number of glomerular cells, collagen deposition and the size of the interstitial space decreased by 20%, 39.4%, and 41.3%, respectively, in the infected group that underwent a second renal insult compared with the infected-treated groups. These functional and structural data show that renal injury observed in a murine model of severe malaria is partially reversed after antimalarial drug treatment, making the kidney less susceptible to a second renal insult.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59384/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL10.1371_journal.pone.0093634.pdfapplication/pdf3489793https://www.arca.fiocruz.br/bitstream/icict/59384/2/10.1371_journal.pone.0093634.pdfb5dfe15ba3dce2af5b8dfbb8c4e8ce0fMD52icict/593842023-07-03 20:58:32.466oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-03T23:58:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| title |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| spellingShingle |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult Abreu, Thiago P. Acute Kidney Injury Animals Antimalarials Collagen Disease Models, Animal Kidney Cortex Kidney Glomerulus Malaria Male Mice Parasitemia Plasmodium berghei Protective Agents Malaria Plasmodium falciparum Sepsis Renal injury Mice Second kidney insult |
| title_short |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| title_full |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| title_fullStr |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| title_full_unstemmed |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| title_sort |
Mice rescued from severe malaria are protected against renal injury during a second kidney insult |
| author |
Abreu, Thiago P. |
| author_facet |
Abreu, Thiago P. Silva, Leandro S. Takiya, Christina M. Souza, Mariana C. Henriques, Maria G. Pinheiro, Ana Acacia S. Caruso-Neves, Celso |
| author_role |
author |
| author2 |
Silva, Leandro S. Takiya, Christina M. Souza, Mariana C. Henriques, Maria G. Pinheiro, Ana Acacia S. Caruso-Neves, Celso |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Abreu, Thiago P. Silva, Leandro S. Takiya, Christina M. Souza, Mariana C. Henriques, Maria G. Pinheiro, Ana Acacia S. Caruso-Neves, Celso |
| dc.subject.mesh.en_US.fl_str_mv |
Acute Kidney Injury Animals Antimalarials Collagen Disease Models, Animal Kidney Cortex Kidney Glomerulus Malaria Male Mice Parasitemia Plasmodium berghei Protective Agents |
| topic |
Acute Kidney Injury Animals Antimalarials Collagen Disease Models, Animal Kidney Cortex Kidney Glomerulus Malaria Male Mice Parasitemia Plasmodium berghei Protective Agents Malaria Plasmodium falciparum Sepsis Renal injury Mice Second kidney insult |
| dc.subject.en.en_US.fl_str_mv |
Malaria Plasmodium falciparum Sepsis Renal injury Mice Second kidney insult |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brazil. |
| publishDate |
2014 |
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2014 |
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2023-07-03T22:13:08Z |
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2023-07-03T22:13:08Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014. |
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https://www.arca.fiocruz.br/handle/icict/59384 |
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1932-6203 |
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10.1371/JOURNAL.PONE.0093634 |
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1932-6203 |
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ABREU, Thiago P. et al. Mice rescued from severe malaria are protected against renal injury during a second kidney insult. PLoS ONE, v. 9, n. 4, p. 1-10, Apr. 2014. 1932-6203 10.1371/JOURNAL.PONE.0093634 |
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