Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44294 |
Resumo: | A.C. Camargo Cancer Center. São Paulo, SP, Brasil. |
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Nassar Junior, Antonio PauloTrevisani, Mariane da SilvaBettim, Barbara BeltrameZampieri, Fernando GodinhoCarvalho Jr, José AlbaniSilva Jr, AmiltonFreitas, Flávio Geraldo Rezende dePinto, Jorge Eduardo da Silva SoaresRomano, EdsonRamos, Silvia ReginaFaria, Guilherme Brenande AlvesAndrade-E-Silva, Ulysses V.Santos, Robson CorreaTommasi, Edmundo de OliveiraMoraes, Ana Paula Pierre deCruz, Bruno Azevedo daBozza, Fernando AugustoCaruso, PedroSalluh, Jorge Ibrahin FigueiraSoares, Marcio2020-10-31T18:59:38Z2020-10-31T18:59:38Z2020NASSAR JUNIOR, Antonio Paulo et al. Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country. PloS One, v. 15, n. 8, p. 1-10, 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4429410.1371/journal.pone.0238124engPublic Library of ScienceElderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income countryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleA.C. Camargo Cancer Center. São Paulo, SP, Brasil.A.C. Camargo Cancer Center. São Paulo, SP, Brasil.A.C. Camargo Cancer Center. São Paulo, SP, Brasil.ID'Or Research and Education Institute. São Paulo, SP, Brazil / Hospital do Coração. Research Institute. São Paulo, SP, Brazil / University of Odense. Center for Epidemiological and Clinical Research. Odense, Denmark.Hospital São Luiz. Rede D'Or. São Paulo, SP, Brasil.Hospital Alemão Oswaldo Cruz. São Paulo, SP, Brasil.Hospital Sepaco. São Paulo, SP, Brasil.Hospital Norte D'Or. Rio de Janeiro, RJ, Brasil.Hospital do Coração. São Paulo, SP, Brasil.Hospital São Luiz. Unidade Assunção. São Bernardo do Campo, SP, Brasil.Hospital Oeste D'Or. Rio de Janeiro, RJ, Brasil.Fundação Pio XII. Hospital de Câncer de Barretos. Barretos, SP, Brasil.Hospital Estadual Adão Pereira Nunes. Duque de Caxias, RJ, Brasil.Hospital Israelita Albert Sabin. Rio de Janeiro, RJ, Brasil.Hospital de Câncer do Maranhão Tarquínio Lopes Filho. São Luís, MA, Brasil.Instituto Nacional de Câncer-HC II. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.A.C. Camargo Cancer Center. São Paulo, SP, Brasil / University of São Paulo. Heart Institute. Discipline of Pulmonology. São Paulo, SP, Brazil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Instituto D'Or de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Background: Very elderly critically ill patients (ie, those older than 75 or 80 years) are an increasing population in intensive care units. However, patients with cancer have encompassed only a minority in epidemiological studies of very old critically-ill patients. We aimed to describe clinical characteristics and identify factors associated with hospital mortality in a cohort of patients aged 80 or older with cancer admitted to intensive care units (ICUs). Methods: This was a retrospective cohort study in 94 ICUs in Brazil. We included patients aged 80 years or older with active cancer who had an unplanned admission. We performed a mixed effect logistic regression model to identify variables independently associated with hospital mortality. Results: Of 4604 included patients, 1807 (39.2%) died in hospital. Solid metastatic (OR = 2.46; CI 95%, 2.01-3.00), hematological cancer (OR = 2.32; CI 95%, 1.75-3.09), moderate/severe performance status impairment (OR = 1.59; CI 95%, 1.33-1.90) and use of vasopressors (OR = 4.74; CI 95%, 3.88-5.79), mechanical ventilation (OR = 1.54; CI 95%, 1.25-1.89) and renal replacement (OR = 1.81; CI 95%, 1.29-2.55) therapy were independently associated with increased hospital mortality. Emergency surgical admissions were associated with lower mortality compared to medical admissions (OR = 0.71; CI 95%, 0.52-0.96). Conclusions: Hospital mortality rate in very elderly critically ill patients with cancer with unplanned ICU admissions are lower than expected a priori. Cancer characteristics, performance status impairment and acute organ dysfunctions are associated with increased mortality.Renal cancerIntensive care unitsProstate cancerBreast cancerGeriatric careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/44294/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALElderly_Fernando_Bozza_etal_INI_2020.pdfElderly_Fernando_Bozza_etal_INI_2020.pdfapplication/pdf824528https://www.arca.fiocruz.br/bitstream/icict/44294/2/Elderly_Fernando_Bozza_etal_INI_2020.pdfce4bea77c42a0a5ea96d414f19c61c5bMD52TEXTElderly_Fernando_Bozza_etal_INI_2020.pdf.txtElderly_Fernando_Bozza_etal_INI_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
title |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
spellingShingle |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country Nassar Junior, Antonio Paulo Renal cancer Intensive care units Prostate cancer Breast cancer Geriatric care |
title_short |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
title_full |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
title_fullStr |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
title_full_unstemmed |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
title_sort |
Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country |
author |
Nassar Junior, Antonio Paulo |
author_facet |
Nassar Junior, Antonio Paulo Trevisani, Mariane da Silva Bettim, Barbara Beltrame Zampieri, Fernando Godinho Carvalho Jr, José Albani Silva Jr, Amilton Freitas, Flávio Geraldo Rezende de Pinto, Jorge Eduardo da Silva Soares Romano, Edson Ramos, Silvia Regina Faria, Guilherme Brenande Alves Andrade-E-Silva, Ulysses V. Santos, Robson Correa Tommasi, Edmundo de Oliveira Moraes, Ana Paula Pierre de Cruz, Bruno Azevedo da Bozza, Fernando Augusto Caruso, Pedro Salluh, Jorge Ibrahin Figueira Soares, Marcio |
author_role |
author |
author2 |
Trevisani, Mariane da Silva Bettim, Barbara Beltrame Zampieri, Fernando Godinho Carvalho Jr, José Albani Silva Jr, Amilton Freitas, Flávio Geraldo Rezende de Pinto, Jorge Eduardo da Silva Soares Romano, Edson Ramos, Silvia Regina Faria, Guilherme Brenande Alves Andrade-E-Silva, Ulysses V. Santos, Robson Correa Tommasi, Edmundo de Oliveira Moraes, Ana Paula Pierre de Cruz, Bruno Azevedo da Bozza, Fernando Augusto Caruso, Pedro Salluh, Jorge Ibrahin Figueira Soares, Marcio |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nassar Junior, Antonio Paulo Trevisani, Mariane da Silva Bettim, Barbara Beltrame Zampieri, Fernando Godinho Carvalho Jr, José Albani Silva Jr, Amilton Freitas, Flávio Geraldo Rezende de Pinto, Jorge Eduardo da Silva Soares Romano, Edson Ramos, Silvia Regina Faria, Guilherme Brenande Alves Andrade-E-Silva, Ulysses V. Santos, Robson Correa Tommasi, Edmundo de Oliveira Moraes, Ana Paula Pierre de Cruz, Bruno Azevedo da Bozza, Fernando Augusto Caruso, Pedro Salluh, Jorge Ibrahin Figueira Soares, Marcio |
dc.subject.en.pt_BR.fl_str_mv |
Renal cancer Intensive care units Prostate cancer Breast cancer Geriatric care |
topic |
Renal cancer Intensive care units Prostate cancer Breast cancer Geriatric care |
description |
A.C. Camargo Cancer Center. São Paulo, SP, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-10-31T18:59:38Z |
dc.date.available.fl_str_mv |
2020-10-31T18:59:38Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NASSAR JUNIOR, Antonio Paulo et al. Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country. PloS One, v. 15, n. 8, p. 1-10, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44294 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0238124 |
identifier_str_mv |
NASSAR JUNIOR, Antonio Paulo et al. Elderly patients with cancer admitted to intensive care unit: A multicenter study in a middle-income country. PloS One, v. 15, n. 8, p. 1-10, 2020. 1932-6203 10.1371/journal.pone.0238124 |
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https://www.arca.fiocruz.br/handle/icict/44294 |
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eng |
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Public Library of Science |
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Public Library of Science |
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