Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Detalhes bibliográficos
Autor(a) principal: Cardoso, Sílvia H.
Data de Publicação: 2009
Outros Autores: Assis, João Vítor de, Almeida, Mauro V. de, Lourenço, Maria Cristina S., Vicente, Felipe R. C., Souza, Marcus V. N. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39059
Resumo: Maria Cristina da Silva Lourenço. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Cardoso, Sílvia H.Assis, João Vítor deAlmeida, Mauro V. deLourenço, Maria Cristina S.Vicente, Felipe R. C.Souza, Marcus V. N. de2020-01-08T13:38:08Z2020-01-08T13:38:08Z2009CARDOSO, Sílvia H. et al. Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives. Química Nova, v. 32, n. 6, p. 1557-1560, 2009.0100-4042https://www.arca.fiocruz.br/handle/icict/3905910.1590/S0100-404220090006000381678-7064Maria Cristina da Silva Lourenço. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in µg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 µg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.engSociedade Brasileira de QuímicaSynthesis and antitubercular activity of isoniazid condensed with carbohydrate derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIsoniazid analogsCarbohydrateAntimycobacterial activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39059/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cardoso_Silvia_etal_INI_2009.pdfve_Cardoso_Silvia_etal_INI_2009.pdfapplication/pdf338800https://www.arca.fiocruz.br/bitstream/icict/39059/2/ve_Cardoso_Silvia_etal_INI_2009.pdf4574b5e7c8b043abc01f45ef69cb9a31MD52TEXTve_Cardoso_Silvia_etal_INI_2009.pdf.txtve_Cardoso_Silvia_etal_INI_2009.pdf.txtExtracted texttext/plain22464https://www.arca.fiocruz.br/bitstream/icict/39059/3/ve_Cardoso_Silvia_etal_INI_2009.pdf.txt41bdcbcc5430a71719375853600d19a8MD53icict/390592020-01-09 02:03:06.668oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-01-09T05:03:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
spellingShingle Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
Cardoso, Sílvia H.
Isoniazid analogs
Carbohydrate
Antimycobacterial activity
title_short Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_full Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_fullStr Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_full_unstemmed Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_sort Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
author Cardoso, Sílvia H.
author_facet Cardoso, Sílvia H.
Assis, João Vítor de
Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Souza, Marcus V. N. de
author_role author
author2 Assis, João Vítor de
Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Souza, Marcus V. N. de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Sílvia H.
Assis, João Vítor de
Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Vicente, Felipe R. C.
Souza, Marcus V. N. de
dc.subject.en.pt_BR.fl_str_mv Isoniazid analogs
Carbohydrate
Antimycobacterial activity
topic Isoniazid analogs
Carbohydrate
Antimycobacterial activity
description Maria Cristina da Silva Lourenço. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-08T13:38:08Z
dc.date.available.fl_str_mv 2020-01-08T13:38:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, Sílvia H. et al. Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives. Química Nova, v. 32, n. 6, p. 1557-1560, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39059
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.doi.none.fl_str_mv 10.1590/S0100-40422009000600038
dc.identifier.eissn.none.fl_str_mv 1678-7064
identifier_str_mv CARDOSO, Sílvia H. et al. Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives. Química Nova, v. 32, n. 6, p. 1557-1560, 2009.
0100-4042
10.1590/S0100-40422009000600038
1678-7064
url https://www.arca.fiocruz.br/handle/icict/39059
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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