A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7380 |
Resumo: | Espirito Santo Federal University Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil. |
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Brocco, Marcos CélioPaulo, Danilo Nagib SalomãoAlmeida, Carlos Eduardo David deCarraretto, Antonio RobertoCabral, Sigmar AureaSilveira, Amanda Cardoso de OliveiraGomez, Renato SantiagoBaptista, João Florêncio de Abreu2014-03-07T13:02:58Z2014-03-07T13:02:58Z2012BROCCO, Marcos Célio et al. A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine. Acta Cirúrgica Brasileira. 2012, vol.27, n.7, pp. 494-4980102-8650https://www.arca.fiocruz.br/handle/icict/7380porSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia.A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEspirito Santo Federal University Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil.EMESCAM. Vitória, ES, Brazil.Universidade Federal de Minas Gerais. Surgical and Ophthalmological Applied Sciences Postgraduate Program. Belo Horizonte, MG, Brazil.Espirito Santo Federal University. Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil.Universidade Federal de Minas Gerais. Surgical and Ophthalmological Applied Sciences Postgraduate Program. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratory analysis and Interpretation of data.Minas Gerais Federal University. Department of Surgery. Belo Horizonte, MG, BrazilEspirito Santo Federal University. Department of Surgery. Division of Anesthesiology. Vitória, ES, BrazilPURPOSE: The objective of this study was to assess the cytokine serum levels of IL-6 and TNF-α in rats subjected to fecal peritonitis and treated with peritoneal lavage with 0.2% ropivacaine by peritoneal lavage. METHODS: We subjected 16 Wistar rats to laparotomy 6 hours after the induction of fecal peritonitis with autogenous stool and subsequently divided the rats randomly into 4 groups: I-control, no treatment; II- drying of the abdominal cavity; III- lavage of the abdominal cavity with 3 mL of 0.9% normal saline and drying; IV- lavage of the abdominal cavity with 3 mL of 0.2% ropivacaine and drying. Six hours following the laparotomy, the animals underwent cardiac puncture, and 1 mL of blood was collected for cytokine assessment before the animals were euthanized. RESULTS: The lavage with ropivacaine resulted in smaller TNF-α levels compared with those observed in the other treatment groups (p <0.05). Regarding IL-6, the ropivacaine group showed lower cytokine levels than those observed in groups I and II, but there was no significant difference (p> 0.05) between groups III and IV. CONCLUSION: Peritoneal lavage with 0.2% ropivacaine was shown to reduce plasma levels of IL-6 and TNF-α in the treatment of fecal peritonitis in ratsPeritonitisAnesthesiaSepsisIL-6info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALA study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine.pdfA study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine.pdfapplication/pdf754724https://www.arca.fiocruz.br/bitstream/icict/7380/1/A%20study%20of%20interleukin%206%20%28IL-6%29%20and%20tumor%20necrosis%20factor%20alpha%20%28TNF-a%29%20serum%20levels%20in%20rats%20subjected%20to%20fecal%20peritonitis%20and%20treated%20with%20intraperitoneal%20ropivacaine.pdf958bfd73ad6f4c5e3d405d9bb3ae0c74MD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| title |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| spellingShingle |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine Brocco, Marcos Célio Peritonitis Anesthesia Sepsis IL-6 |
| title_short |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| title_full |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| title_fullStr |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| title_full_unstemmed |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| title_sort |
A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine |
| author |
Brocco, Marcos Célio |
| author_facet |
Brocco, Marcos Célio Paulo, Danilo Nagib Salomão Almeida, Carlos Eduardo David de Carraretto, Antonio Roberto Cabral, Sigmar Aurea Silveira, Amanda Cardoso de Oliveira Gomez, Renato Santiago Baptista, João Florêncio de Abreu |
| author_role |
author |
| author2 |
Paulo, Danilo Nagib Salomão Almeida, Carlos Eduardo David de Carraretto, Antonio Roberto Cabral, Sigmar Aurea Silveira, Amanda Cardoso de Oliveira Gomez, Renato Santiago Baptista, João Florêncio de Abreu |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brocco, Marcos Célio Paulo, Danilo Nagib Salomão Almeida, Carlos Eduardo David de Carraretto, Antonio Roberto Cabral, Sigmar Aurea Silveira, Amanda Cardoso de Oliveira Gomez, Renato Santiago Baptista, João Florêncio de Abreu |
| dc.subject.en.pt_BR.fl_str_mv |
Peritonitis Anesthesia Sepsis IL-6 |
| topic |
Peritonitis Anesthesia Sepsis IL-6 |
| description |
Espirito Santo Federal University Department of Surgery. Division of Anesthesiology. Vitória, ES, Brazil. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2014-03-07T13:02:58Z |
| dc.date.available.fl_str_mv |
2014-03-07T13:02:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BROCCO, Marcos Célio et al. A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine. Acta Cirúrgica Brasileira. 2012, vol.27, n.7, pp. 494-498 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7380 |
| dc.identifier.issn.none.fl_str_mv |
0102-8650 |
| identifier_str_mv |
BROCCO, Marcos Célio et al. A study of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) serum levels in rats subjected to fecal peritonitis and treated with intraperitoneal ropivacaine. Acta Cirúrgica Brasileira. 2012, vol.27, n.7, pp. 494-498 0102-8650 |
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https://www.arca.fiocruz.br/handle/icict/7380 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. |
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Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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