Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26313 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. |
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Nico, DirleiConde, LucianaRivera-Correa, Juan L.Santos, Andréia Vasconcelos dosMesentier-Louro, LouiseLima, Leonardo Freire deArruda, Mônica BarcellosLima, Celio Geraldo Freire deFerreira, Orlando da CostaMoreira, Maria Elisabeth LopesZin, AndreaVasconcelos, Zilton Farias Meira deOtero, Rosalia MendezSousa, Clarisa Beatriz Palatnik deTanuri, AmilcarTodeschini, Adriane ReginaSavino, WilsonRodriguez, AnaMorrot, Alexandre2018-05-08T11:33:58Z2018-05-08T11:33:58Z2018NICO, Dirlei et al. Prevalence of igg autoantibodies against gD3 ganglioside in acute Zika Virus infection. Frontiers in Medicine, v. 5, p. 1-8, 2018.2296-858Xhttps://www.arca.fiocruz.br/handle/icict/2631310.3389/fmed.2018.00025engFrontiers MediaZika virusDoenças infecciosasAutoimunidadeGangliosídeosZika virusGangliosidesAutoimmunityAutoantibodyInfectious diseasesPrevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Department of Microbiology. New York, NY, USA.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro.Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro.Departamento de Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Unidade de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro.Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.New York University School of Medicine. Department of Microbiology. New York, NY, USA.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Centro de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain-Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neurological disorders. Gangliosides are a class of galactose-containing cerebrosides mainly expressed in nervous system tissues playing a critical role in the physiology of neural cells and neurogenesis. Herein, our findings indicate that patients at acute phase of ZIKV infection without any neurological signs show increased levels of IgG autoantibody against GD3 gangliosides, a class of glycolipid found to be highly expressed in neural stem cell acting in the maintenance of their self-renewal cellular capacity. It is possible that a pathological threshold of these antibodies is only acquired in secondary or subsequent infections. In the light of these evidences, we propose that the target of GD3 by autoimmune responses may possibly has an effect in the neuropathy and neurogenesis disorder seen during ZIKV infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26313/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalexandre_morrot_etal_IOC_2018.pdfalexandre_morrot_etal_IOC_2018.pdfapplication/pdf1200001https://www.arca.fiocruz.br/bitstream/icict/26313/2/alexandre_morrot_etal_IOC_2018.pdf70c2b01bf9d228518eff13287ab7d86cMD52TEXTalexandre_morrot_etal_IOC_2018.pdf.txtalexandre_morrot_etal_IOC_2018.pdf.txtExtracted texttext/plain46119https://www.arca.fiocruz.br/bitstream/icict/26313/3/alexandre_morrot_etal_IOC_2018.pdf.txt70375f50049561453a145d8dcd5eeeebMD53icict/263132023-09-05 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dc.title.pt_BR.fl_str_mv |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
title |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
spellingShingle |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection Nico, Dirlei Zika virus Doenças infecciosas Autoimunidade Gangliosídeos Zika virus Gangliosides Autoimmunity Autoantibody Infectious diseases |
title_short |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
title_full |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
title_fullStr |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
title_full_unstemmed |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
title_sort |
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection |
author |
Nico, Dirlei |
author_facet |
Nico, Dirlei Conde, Luciana Rivera-Correa, Juan L. Santos, Andréia Vasconcelos dos Mesentier-Louro, Louise Lima, Leonardo Freire de Arruda, Mônica Barcellos Lima, Celio Geraldo Freire de Ferreira, Orlando da Costa Moreira, Maria Elisabeth Lopes Zin, Andrea Vasconcelos, Zilton Farias Meira de Otero, Rosalia Mendez Sousa, Clarisa Beatriz Palatnik de Tanuri, Amilcar Todeschini, Adriane Regina Savino, Wilson Rodriguez, Ana Morrot, Alexandre |
author_role |
author |
author2 |
Conde, Luciana Rivera-Correa, Juan L. Santos, Andréia Vasconcelos dos Mesentier-Louro, Louise Lima, Leonardo Freire de Arruda, Mônica Barcellos Lima, Celio Geraldo Freire de Ferreira, Orlando da Costa Moreira, Maria Elisabeth Lopes Zin, Andrea Vasconcelos, Zilton Farias Meira de Otero, Rosalia Mendez Sousa, Clarisa Beatriz Palatnik de Tanuri, Amilcar Todeschini, Adriane Regina Savino, Wilson Rodriguez, Ana Morrot, Alexandre |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nico, Dirlei Conde, Luciana Rivera-Correa, Juan L. Santos, Andréia Vasconcelos dos Mesentier-Louro, Louise Lima, Leonardo Freire de Arruda, Mônica Barcellos Lima, Celio Geraldo Freire de Ferreira, Orlando da Costa Moreira, Maria Elisabeth Lopes Zin, Andrea Vasconcelos, Zilton Farias Meira de Otero, Rosalia Mendez Sousa, Clarisa Beatriz Palatnik de Tanuri, Amilcar Todeschini, Adriane Regina Savino, Wilson Rodriguez, Ana Morrot, Alexandre |
dc.subject.other.pt_BR.fl_str_mv |
Zika virus Doenças infecciosas Autoimunidade Gangliosídeos |
topic |
Zika virus Doenças infecciosas Autoimunidade Gangliosídeos Zika virus Gangliosides Autoimmunity Autoantibody Infectious diseases |
dc.subject.en.pt_BR.fl_str_mv |
Zika virus Gangliosides Autoimmunity Autoantibody Infectious diseases |
description |
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-08T11:33:58Z |
dc.date.available.fl_str_mv |
2018-05-08T11:33:58Z |
dc.date.issued.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
NICO, Dirlei et al. Prevalence of igg autoantibodies against gD3 ganglioside in acute Zika Virus infection. Frontiers in Medicine, v. 5, p. 1-8, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26313 |
dc.identifier.issn.pt_BR.fl_str_mv |
2296-858X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmed.2018.00025 |
identifier_str_mv |
NICO, Dirlei et al. Prevalence of igg autoantibodies against gD3 ganglioside in acute Zika Virus infection. Frontiers in Medicine, v. 5, p. 1-8, 2018. 2296-858X 10.3389/fmed.2018.00025 |
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https://www.arca.fiocruz.br/handle/icict/26313 |
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eng |
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eng |
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Frontiers Media |
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Frontiers Media |
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