Early clinical manifestaions associated with death from visceral leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Araújo, Valdelaine Etelvina Miranda de
Data de Publicação: 2012
Outros Autores: Morais, Maria Helena Franco, Reis, Ilka Afonso, Rabello, Ana Lúcia Teles, Carneiro, Mariângela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7352
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, Brazil
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spelling Araújo, Valdelaine Etelvina Miranda deMorais, Maria Helena FrancoReis, Ilka AfonsoRabello, Ana Lúcia TelesCarneiro, Mariângela2014-02-25T16:49:37Z2014-02-25T16:49:37Z2012ARAUJO, Valdelaine Etelvina Miranda de et al. Early clinical manifestaions associated with death from visceral leishmaniasis. Plos Neglected Tropical Diseases. 2012, vol.6, pp. 1511-15191935-2735https://www.arca.fiocruz.br/handle/icict/735210.1371/journal.pntd.0001511engPublic Library of ScienceEarly clinical manifestaions associated with death from visceral leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, BrazilBackground In Brazil, lethality from visceral leishmaniasis (VL) is high and few studies have addressed prognostic factors. This historical cohort study was designed to investigate the prognostic factors for death from VL in Belo Horizonte (Brazil). Methodology The analysis was based on data of the Reportable Disease Information System-SINAN (Brazilian Ministry of Health) relating to the clinical manifestations of the disease. During the study period (2002–2009), the SINAN changed platform from a Windows to a Net-version that differed with respect to some of the parameters collected. Multivariate logistic regression models were performed to identify variables associated with death from VL, and these were included in prognostic score. Principal Findings Model 1 (period 2002–2009; 111 deaths from VL and 777 cured patients) included the variables present in both SINAN versions, whereas Model 2 (period 2007–2009; 49 deaths from VL and 327 cured patients) included variables common to both SINAN versions plus the additional variables included in the Net version. In Model 1, the variables significantly associated with a greater risk of death from VL were weakness (OR 2.9; 95%CI 1.3–6.4), Leishmania-HIV co-infection (OR 2.4; 95%CI 1.2–4.8) and age ≥60 years (OR 2.5; 95%CI 1.5–4.3). In Model 2, the variables were bleeding (OR 3.5; 95%CI 1.2–10.3), other associated infections (OR 3.2; 95%CI 1.3–7.8), jaundice (OR 10.1; 95%CI 3.7–27.2) and age ≥60 years (OR 3.1; 95%CI 1.4–7.1). The prognosis score was developed using the variables associated with death from VL of the latest version of the SINAN (Model 2). The predictive performance of which was evaluated by sensitivity (71.4%), specificity (73.7%), positive and negative predictive values (28.9% and 94.5%) and area under the receiver operating characteristic curve (75.6%). Conclusions Knowledge regarding the factors associated with death from VL may improve clinical management of patients and contribute to lower mortality.BrazilCo-infectionsDrug administrationDrug therapyHemorrhageLeishmaniasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEarly clinical manifestaions associated with death from visceral leishmaniasis..pdfEarly clinical manifestaions associated with death from visceral leishmaniasis..pdfapplication/pdf2112418https://www.arca.fiocruz.br/bitstream/icict/7352/1/Early%20clinical%20manifestaions%20associated%20with%20death%20from%20visceral%20leishmaniasis..pdf923ab02541a12306f9cf3d95e8ec1994MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7352/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTEarly clinical manifestaions associated with death from visceral leishmaniasis..pdf.txtEarly clinical manifestaions associated with death from visceral leishmaniasis..pdf.txtExtracted texttext/plain9https://www.arca.fiocruz.br/bitstream/icict/7352/5/Early%20clinical%20manifestaions%20associated%20with%20death%20from%20visceral%20leishmaniasis..pdf.txt33f4f15a16a9843faf6a25d4f387b6fdMD55THUMBNAILEarly clinical manifestaions associated with death from visceral leishmaniasis..pdf.jpgEarly clinical manifestaions associated with death from visceral leishmaniasis..pdf.jpgGenerated Thumbnailimage/jpeg2302https://www.arca.fiocruz.br/bitstream/icict/7352/4/Early%20clinical%20manifestaions%20associated%20with%20death%20from%20visceral%20leishmaniasis..pdf.jpg5b0f858c5c2e08e332ebcc4459921c95MD54icict/73522018-04-06 08:48:43.07oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:48:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Early clinical manifestaions associated with death from visceral leishmaniasis
title Early clinical manifestaions associated with death from visceral leishmaniasis
spellingShingle Early clinical manifestaions associated with death from visceral leishmaniasis
Araújo, Valdelaine Etelvina Miranda de
Brazil
Co-infections
Drug administration
Drug therapy
Hemorrhage
Leishmaniasis
title_short Early clinical manifestaions associated with death from visceral leishmaniasis
title_full Early clinical manifestaions associated with death from visceral leishmaniasis
title_fullStr Early clinical manifestaions associated with death from visceral leishmaniasis
title_full_unstemmed Early clinical manifestaions associated with death from visceral leishmaniasis
title_sort Early clinical manifestaions associated with death from visceral leishmaniasis
author Araújo, Valdelaine Etelvina Miranda de
author_facet Araújo, Valdelaine Etelvina Miranda de
Morais, Maria Helena Franco
Reis, Ilka Afonso
Rabello, Ana Lúcia Teles
Carneiro, Mariângela
author_role author
author2 Morais, Maria Helena Franco
Reis, Ilka Afonso
Rabello, Ana Lúcia Teles
Carneiro, Mariângela
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Araújo, Valdelaine Etelvina Miranda de
Morais, Maria Helena Franco
Reis, Ilka Afonso
Rabello, Ana Lúcia Teles
Carneiro, Mariângela
dc.subject.en.pt_BR.fl_str_mv Brazil
Co-infections
Drug administration
Drug therapy
Hemorrhage
Leishmaniasis
topic Brazil
Co-infections
Drug administration
Drug therapy
Hemorrhage
Leishmaniasis
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Prefeitura de Belo Horizonte. Secretaria Municipal de Saúde. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-02-25T16:49:37Z
dc.date.available.fl_str_mv 2014-02-25T16:49:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, Valdelaine Etelvina Miranda de et al. Early clinical manifestaions associated with death from visceral leishmaniasis. Plos Neglected Tropical Diseases. 2012, vol.6, pp. 1511-1519
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7352
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001511
identifier_str_mv ARAUJO, Valdelaine Etelvina Miranda de et al. Early clinical manifestaions associated with death from visceral leishmaniasis. Plos Neglected Tropical Diseases. 2012, vol.6, pp. 1511-1519
1935-2735
10.1371/journal.pntd.0001511
url https://www.arca.fiocruz.br/handle/icict/7352
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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