Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis

Detalhes bibliográficos
Autor(a) principal: Brito, Nayara Castelano
Data de Publicação: 2020
Outros Autores: Assis, Tália Santana Machado de, Rabello, Ana Lúcia Teles, Cota, Gláucia Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42919
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brazil
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spelling Brito, Nayara CastelanoAssis, Tália Santana Machado deRabello, Ana Lúcia TelesCota, Gláucia Fernandes2020-08-24T17:02:28Z2020-08-24T17:02:28Z2020BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.00078561935-2727https://www.arca.fiocruz.br/handle/icict/4291910.1371/journal.pntd.0007856engPublic Library of ScienceIntralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, BrazilCutaneous leishmaniasis (LC) is a complex and variable disease in terms of epidemiology, aetiology, pathology and clinical characteristics. The mainstay of treatment is still pentavalent antimony (Sbv) compounds administered systemically, despite their recognized toxicity. The advantages of antimony intralesional (IL) infiltration are the use of lower doses of Sbv and, therefore, less toxic effects. The objective of this study was to estimate the cost-effectiveness ratio of intralesional meglumine antimoniate therapy (IL-MA) compared with endovenous meglumine antimoniate therapy (EV-MA) for the treatment of CL in the context of the Brazilian National Health System (SUS). An analytical decision model (decision tree) was developed using TreeAge Pro 2018 software. Data from the open-label, uncontrolled phase II clinical trial evaluating IL-MA were used as a reference for posology, efficacy, and adverse event rates (AE). The same premises for the intravenous approach (EV-MA) were extracted from systematic literature reviews. Macro and micro calculations of spending were included in the analysis. The IL-MA and EV-MA strategies had a total cost per patient cured of US$330.81 and US$494.16, respectively. The intralesional approach was dominant, meaning it was more economic and effective than was endovenous therapy. The incremental cost-effectiveness ratio showed that IL-MA could result in savings of US$864.37 for each additional patient cured, confirming that the IL-MA strategy is cost effective in the context of the Brazilian public health scenario.Cost-effectiveness analysisTherapeutic drug monitoringBrazilAdverse eventsDrug therapyDrug administrationLeishmaniasisAntimonyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/42919/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIntralesional infiltration versus parenteral.pdfIntralesional infiltration versus parenteral.pdfapplication/pdf786665https://www.arca.fiocruz.br/bitstream/icict/42919/2/Intralesional%20infiltration%20versus%20parenteral.pdfcb3694d50135d28b8d2f316a0fb96206MD52TEXTIntralesional infiltration versus parenteral.pdf.txtIntralesional 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dc.title.pt_BR.fl_str_mv Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
title Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
spellingShingle Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
Brito, Nayara Castelano
Cost-effectiveness analysis
Therapeutic drug monitoring
Brazil
Adverse events
Drug therapy
Drug administration
Leishmaniasis
Antimony
title_short Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
title_full Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
title_fullStr Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
title_full_unstemmed Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
title_sort Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis
author Brito, Nayara Castelano
author_facet Brito, Nayara Castelano
Assis, Tália Santana Machado de
Rabello, Ana Lúcia Teles
Cota, Gláucia Fernandes
author_role author
author2 Assis, Tália Santana Machado de
Rabello, Ana Lúcia Teles
Cota, Gláucia Fernandes
author2_role author
author
author
dc.contributor.author.fl_str_mv Brito, Nayara Castelano
Assis, Tália Santana Machado de
Rabello, Ana Lúcia Teles
Cota, Gláucia Fernandes
dc.subject.en.pt_BR.fl_str_mv Cost-effectiveness analysis
Therapeutic drug monitoring
Brazil
Adverse events
Drug therapy
Drug administration
Leishmaniasis
Antimony
topic Cost-effectiveness analysis
Therapeutic drug monitoring
Brazil
Adverse events
Drug therapy
Drug administration
Leishmaniasis
Antimony
description Fundação Oswaldo Cruz. Instituto René Rachou. Clínica e Políticas Públicas em Doenças Infecto-Parasitárias. Belo Horizonte, MG, Brazil
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-24T17:02:28Z
dc.date.available.fl_str_mv 2020-08-24T17:02:28Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.0007856
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42919
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007856
identifier_str_mv BRITO, Nayara Castelano et al. Intralesional infiltration versus parenteral use of meglumine antimoniate for treatment of cutaneous leishmaniasis: A cost-effectiveness analysis. PLoS Negl Trop Dis, v. 13, n. 12, e0007856, 2020. https://doi.org/10.1371/journal.pntd.0007856
1935-2727
10.1371/journal.pntd.0007856
url https://www.arca.fiocruz.br/handle/icict/42919
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/42919/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/42919/2/Intralesional%20infiltration%20versus%20parenteral.pdf
https://www.arca.fiocruz.br/bitstream/icict/42919/3/Intralesional%20infiltration%20versus%20parenteral.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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