Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients
| Main Author: | |
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| Publication Date: | 2020 |
| Other Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/45469 |
Summary: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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Sánchez-Arcila, Juan CamiloBadolato-Correa, JessicaSouza, Thiara Manuele Alves dePaiva, Iury AmâncioBarbosa, Luciana SantosNunes, Priscila Conrado GuerraLima, Monique da Rocha QueirozSantos, Flavia Barrento dosDamasco, Paulo VieiraCunha, Rivaldo Venancio daAzeredo, Elzinandes Leal dePinto, Luzia Maria de Oliveira2020-12-29T19:13:27Z2020-12-29T19:13:27Z2020SANCHÉZ-ARCILA, Juan Camilo et al. Clinical, virological and immunological profiles of DENV, ZIKV, AND;OR CHIKV-Infected Brazilian Patients. Intervirology, v. 63, p. 33-45, Sept. 2020.0300-5526https://www.arca.fiocruz.br/handle/icict/45469engEuropean Society for Paedriatric Infectious DiseasesZikaDiagnósticoDengueResposta sorológicaResposta imune mediada por célulasZikaDiagnosticsSerologic responseCell-mediated immune responseDengueClinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria e Puericultura Martigão Gesteira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Rio de Janeiro, RJ, Brasil.Universidade Federal do Mato Grosso do Sul. Departamento de Clínica Médica. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Background Clinical, virologic, and immunologic characteristics of Zika virus (ZIKV) infections in US patients are poorly defined. Methods US subjects with suspected ZIKV infection were enrolled. Clinical data and specimens were prospectively collected for ZIKV RNA detection and serologic and cellular assays. Confirmed ZIKV infection (cases) and ZIKV-negative (controls) subjects were compared. Dengue-experienced and dengue-naïve cases were also compared. Results We enrolled 45 cases and 14 controls. Commonly reported symptoms among cases and controls were maculopapular rash (97.8% and 81.8%), fatigue (86.7% and 81.8%), and arthralgia (82.2% and 54.5%), respectively. The sensitivity (94%) and duration of infection detection (80% positivity at 65–79 days after disease onset) by polymerase chain reaction were highest in whole-blood specimens. ZIKV-neutralizing antibodies had a half-life of 105 days and were significantly higher in dengue virus–experienced cases than naïve ones (P = .046). In intracellular cytokine staining assays, the ZIKV proteins targeted most often by peripheral blood mononuclear cells from cases were structural proteins C and E for CD4+ T cells and nonstructural proteins NS3, NS5, and NS4B for CD8+ T cells. Conclusions ZIKV RNA detection was more frequent and prolonged in whole-blood specimens. Immunoglobulin G (IgG) and neutralizing antibodies, but not IgM, were influenced by prior dengue infection. Robust cellular responses to E and nonstructural proteins have potential vaccine development implications.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45469/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJessicaCorrea_MoniqueLima_etal_IOC_2020.pdfJessicaCorrea_MoniqueLima_etal_IOC_2020.pdfapplication/pdf567217https://www.arca.fiocruz.br/bitstream/icict/45469/2/JessicaCorrea_MoniqueLima_etal_IOC_2020.pdf11ad2591f78a83a32534529c2cde4f70MD52TEXTJessicaCorrea_MoniqueLima_etal_IOC_2020.pdf.txtJessicaCorrea_MoniqueLima_etal_IOC_2020.pdf.txtExtracted texttext/plain58473https://www.arca.fiocruz.br/bitstream/icict/45469/3/JessicaCorrea_MoniqueLima_etal_IOC_2020.pdf.txt7668e8f215eb220ecfb10faca0c09739MD53icict/454692020-12-30 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| dc.title.pt_BR.fl_str_mv |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| title |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| spellingShingle |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients Sánchez-Arcila, Juan Camilo Zika Diagnóstico Dengue Resposta sorológica Resposta imune mediada por células Zika Diagnostics Serologic response Cell-mediated immune response Dengue |
| title_short |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| title_full |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| title_fullStr |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| title_full_unstemmed |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| title_sort |
Clinical, virological, and immunological profiles of DENV, ZIKV, and/or CHIKV-infected Brazilian patients |
| author |
Sánchez-Arcila, Juan Camilo |
| author_facet |
Sánchez-Arcila, Juan Camilo Badolato-Correa, Jessica Souza, Thiara Manuele Alves de Paiva, Iury Amâncio Barbosa, Luciana Santos Nunes, Priscila Conrado Guerra Lima, Monique da Rocha Queiroz Santos, Flavia Barrento dos Damasco, Paulo Vieira Cunha, Rivaldo Venancio da Azeredo, Elzinandes Leal de Pinto, Luzia Maria de Oliveira |
| author_role |
author |
| author2 |
Badolato-Correa, Jessica Souza, Thiara Manuele Alves de Paiva, Iury Amâncio Barbosa, Luciana Santos Nunes, Priscila Conrado Guerra Lima, Monique da Rocha Queiroz Santos, Flavia Barrento dos Damasco, Paulo Vieira Cunha, Rivaldo Venancio da Azeredo, Elzinandes Leal de Pinto, Luzia Maria de Oliveira |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sánchez-Arcila, Juan Camilo Badolato-Correa, Jessica Souza, Thiara Manuele Alves de Paiva, Iury Amâncio Barbosa, Luciana Santos Nunes, Priscila Conrado Guerra Lima, Monique da Rocha Queiroz Santos, Flavia Barrento dos Damasco, Paulo Vieira Cunha, Rivaldo Venancio da Azeredo, Elzinandes Leal de Pinto, Luzia Maria de Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Zika Diagnóstico Dengue Resposta sorológica Resposta imune mediada por células |
| topic |
Zika Diagnóstico Dengue Resposta sorológica Resposta imune mediada por células Zika Diagnostics Serologic response Cell-mediated immune response Dengue |
| dc.subject.en.pt_BR.fl_str_mv |
Zika Diagnostics Serologic response Cell-mediated immune response Dengue |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-12-29T19:13:27Z |
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2020-12-29T19:13:27Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SANCHÉZ-ARCILA, Juan Camilo et al. Clinical, virological and immunological profiles of DENV, ZIKV, AND;OR CHIKV-Infected Brazilian Patients. Intervirology, v. 63, p. 33-45, Sept. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45469 |
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0300-5526 |
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SANCHÉZ-ARCILA, Juan Camilo et al. Clinical, virological and immunological profiles of DENV, ZIKV, AND;OR CHIKV-Infected Brazilian Patients. Intervirology, v. 63, p. 33-45, Sept. 2020. 0300-5526 |
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European Society for Paedriatric Infectious Diseases |
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European Society for Paedriatric Infectious Diseases |
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