An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Oliveira-Ribeiro, Carla
Data de Publicação: 2021
Outros Autores: Pimentel, Maria Inês Fernandes, Oliveira, Liliane de Fátima Antonio, Vasconcellos, Érica de Camargo Ferreira E., Conceição-Silva, Fatima, Schubach, Armando de Oliveira, Fagundes, Aline, Mello, Cintia Xavier de, Mouta-Confort, Eliame, Miranda, Luciana de Freitas Campos, Valete-Rosalino, Claudia Maria, Martins, Ana Cristina da Costa, Oliveira, Raquel de Vasconcellos Carvalhaes de, Quintella, Leonardo Pereira, Lyra, Marcelo Rosandiski
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50184
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira-Ribeiro, CarlaPimentel, Maria Inês FernandesOliveira, Liliane de Fátima AntonioVasconcellos, Érica de Camargo Ferreira E.Conceição-Silva, FatimaSchubach, Armando de OliveiraFagundes, AlineMello, Cintia Xavier deMouta-Confort, EliameMiranda, Luciana de Freitas CamposValete-Rosalino, Claudia MariaMartins, Ana Cristina da CostaOliveira, Raquel de Vasconcellos Carvalhaes deQuintella, Leonardo PereiraLyra, Marcelo Rosandiski2021-12-06T15:45:22Z2021-12-06T15:45:22Z2021OLIVEIRA-RIBEIRO, Carla et al. An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil. PLoS neglected tropical diseases, v. 15, n. 9, p. 1-25, 20211935-2735https://www.arca.fiocruz.br/handle/icict/5018410.1371/journal.pntd.0009734engPublic Library of ScienceAn old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Escola de Medicina Souza Marques. Rio de Janeiro, RJ, Brasil / Centro Universitário de Volta Redonda. Faculdade de Medicina. Volta Redonda, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Otorrinolaringologia e Oftalmologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Background: Treatment of cutaneous leishmaniasis (CL) remains challenging since the drugs currently used are quite toxic, thus contributing to lethality unrelated to the disease itself but to adverse events (AE). The main objective was to evaluate different treatment regimens with meglumine antimoniate (MA), in a reference center in Rio de Janeiro, Brazil. Methodology: A historical cohort of 592 patients that underwent physical and laboratory examination were enrolled between 2000 and 2017. The outcome measures of effectiveness were epithelialization and complete healing of cutaneous lesions. AE were graded using a standardized scale. Three groups were evaluated: Standard regimen (SR): intramuscular (IM) MA 10-20 mg Sb5+/kg/day during 20 days (n = 46); Alternative regimen (AR): IM MA 5 mg Sb5+/kg/day during 30 days (n = 456); Intralesional route (IL): MA infiltration in the lesion(s) through subcutaneous injections (n = 90). Statistical analysis was performed through Fisher exact and Pearson Chi-square tests, Kruskal-Wallis, Kaplan-Meier and log-rank tests. Results: SR, AR and IL showed efficacy of 95.3%, 84.3% and 75.9%, with abandonment rate of 6.5%, 2.4% and 3.4%, respectively. IL patients had more comorbidities (58.9%; p = 0.001), were mostly over 50 years of age (55.6%), and had an evolution time longer than 2 months (65.6%; p = 0.02). Time for epithelialization and complete healing were similar in IL and IM MA groups (p = 0.9 and p = 0.5; respectively). Total AE and moderate to severe AE that frequently led to treatment interruption were more common in SR group, while AR and IL showed less toxicity. Conclusions/significance: AR and IL showed less toxicity and may be good options especially in CL cases with comorbidities, although SR treatment was more effective. IL treatment was an effective and safe strategy, and it may be used as first therapy option as well as a rescue scheme in patients initially treated with other drugs.LesionsAdverse eventsDrug therapyLeishmaniasisTissue repairBrazilWound healingToxicityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50184/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALAn old drug_Carla_Ribeiro_etal_INI_2021.pdfAn old drug_Carla_Ribeiro_etal_INI_2021.pdfapplication/pdf1482820https://www.arca.fiocruz.br/bitstream/icict/50184/2/An%20old%20drug_Carla_Ribeiro_etal_INI_2021.pdf6684ad1de3723e1a68d8e67a8df20777MD52icict/501842021-12-06 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dc.title.pt_BR.fl_str_mv An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
title An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
spellingShingle An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
Oliveira-Ribeiro, Carla
Lesions
Adverse events
Drug therapy
Leishmaniasis
Tissue repair
Brazil
Wound healing
Toxicity
title_short An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
title_full An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
title_fullStr An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
title_full_unstemmed An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
title_sort An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil
author Oliveira-Ribeiro, Carla
author_facet Oliveira-Ribeiro, Carla
Pimentel, Maria Inês Fernandes
Oliveira, Liliane de Fátima Antonio
Vasconcellos, Érica de Camargo Ferreira E.
Conceição-Silva, Fatima
Schubach, Armando de Oliveira
Fagundes, Aline
Mello, Cintia Xavier de
Mouta-Confort, Eliame
Miranda, Luciana de Freitas Campos
Valete-Rosalino, Claudia Maria
Martins, Ana Cristina da Costa
Oliveira, Raquel de Vasconcellos Carvalhaes de
Quintella, Leonardo Pereira
Lyra, Marcelo Rosandiski
author_role author
author2 Pimentel, Maria Inês Fernandes
Oliveira, Liliane de Fátima Antonio
Vasconcellos, Érica de Camargo Ferreira E.
Conceição-Silva, Fatima
Schubach, Armando de Oliveira
Fagundes, Aline
Mello, Cintia Xavier de
Mouta-Confort, Eliame
Miranda, Luciana de Freitas Campos
Valete-Rosalino, Claudia Maria
Martins, Ana Cristina da Costa
Oliveira, Raquel de Vasconcellos Carvalhaes de
Quintella, Leonardo Pereira
Lyra, Marcelo Rosandiski
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira-Ribeiro, Carla
Pimentel, Maria Inês Fernandes
Oliveira, Liliane de Fátima Antonio
Vasconcellos, Érica de Camargo Ferreira E.
Conceição-Silva, Fatima
Schubach, Armando de Oliveira
Fagundes, Aline
Mello, Cintia Xavier de
Mouta-Confort, Eliame
Miranda, Luciana de Freitas Campos
Valete-Rosalino, Claudia Maria
Martins, Ana Cristina da Costa
Oliveira, Raquel de Vasconcellos Carvalhaes de
Quintella, Leonardo Pereira
Lyra, Marcelo Rosandiski
dc.subject.en.pt_BR.fl_str_mv Lesions
Adverse events
Drug therapy
Leishmaniasis
Tissue repair
Brazil
Wound healing
Toxicity
topic Lesions
Adverse events
Drug therapy
Leishmaniasis
Tissue repair
Brazil
Wound healing
Toxicity
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer José Alencar Gomes da Silva. Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-06T15:45:22Z
dc.date.available.fl_str_mv 2021-12-06T15:45:22Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA-RIBEIRO, Carla et al. An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil. PLoS neglected tropical diseases, v. 15, n. 9, p. 1-25, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50184
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0009734
identifier_str_mv OLIVEIRA-RIBEIRO, Carla et al. An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil. PLoS neglected tropical diseases, v. 15, n. 9, p. 1-25, 2021
1935-2735
10.1371/journal.pntd.0009734
url https://www.arca.fiocruz.br/handle/icict/50184
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50184/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50184/2/An%20old%20drug_Carla_Ribeiro_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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