Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients

Detalhes bibliográficos
Autor(a) principal: Gomes, Juliana de Assis Silva
Data de Publicação: 2018
Outros Autores: Araújo, Fernanda Fortes de, Avelar, Daniele Marquete Vitelli, Avelar, Renato Sathler, Lage, Paula Souza, Wendling, Ana Paula Barbosa, Vale, Isabela Natalia Pascoal Campos do, Dias, João Carlos Pinto, Santos, Silvana Maria Elói, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32941
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.
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spelling Gomes, Juliana de Assis SilvaAraújo, Fernanda Fortes deAvelar, Daniele Marquete VitelliAvelar, Renato SathlerLage, Paula SouzaWendling, Ana Paula BarbosaVale, Isabela Natalia Pascoal Campos doDias, João Carlos PintoSantos, Silvana Maria ElóiCarvalho, Andréa Teixeira deMartins Filho, Olindo Assis2019-05-06T13:03:30Z2019-05-06T13:03:30Z2018GOMES, Juliana de Assis Silva et al. Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients. Frontiers in Microbiology, v. 9, p. 1-10, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3294110.3389/fmicb.2018.01608engFrontiers Research FoundationDoença de ChagasReceptores FcTrypanosoma cruziCitocinasResposta imuneChagas diseaseFc receptorsTrypanosoma cruziCytokinesImmune responseSystems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil / Universidade de Uberaba. Programa de Pós-graduação em Sanidade e Produção Animal nos Trópicos. Uberaba, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Triatomíneos. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedêutica Complementar. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil.The systems biology approach has become an innovative tool when it comes to shedding light on the complex immune response underlying the development/maintenance of distinct clinical forms of Chagas disease. The goal of this study was to describe an integrative overview of Fc-γR expression, cytokine microenvironment and anti-Trypanosoma cruzi IgG interface in indeterminate-(IND) and cardiac-(CARD) patients. Data demonstrated that IND displayed an overall higher Fcγ-R expression (CD16; CD32; CD64) on neutrophils-(NEU), along with (CD16; CD64) on monocytes-(MON) as compared to CARD. Additionally, CARD presented an increased expression of CD32 in B-cells. While preserved frequency of IL-10-producing cells was observed in IND, decreased levels of IL-10+ phagocytes and enhanced TNF+ MON and NK-cells were observed in CARD. T. cruzi-antigen recall in vitro induces a general decrease of Fc-γR expression in Chagas disease patients, especially in CARD. Moreover, T. cruzi-antigen stimuli triggered a concomitant increase of IFN-γ+NEU/TNF+NK-cells and IL-10+MON/IL-10+B-cells in IND. Biomarker signatures further emphasized the contrasting Fc-γR expression and cytokine microenvironment observed in Chagas disease patients with distinct clinical forms. Up-regulation of Fc-γR expression (CD16 on NEU;MON;NK) was observed in IND, whereas a general decrease was reported for CARD. Moreover, while a mixed cytokine microenvironment (TNF; IL-10) was observed in IND, CARD presented a contrasting profile with up-regulation of TNF+NEU and IL-12+NEU. Integrative network analysis revealed a distinct assemblage of biomarkers, with CARD presenting a large number of negative internode connectivity in comparison with IND. The relevant gaps in Fc-γR expression and impaired regulatory cytokine microenvironment interfaced with the anti-T. cruzi IgG reactivity throughout an exacerbated negative connectivity may account for the development/maintenance of the clinical status of cardiac Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/32941/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALBystems Biology Reveals.pdfBystems Biology Reveals.pdfapplication/pdf5254008https://www.arca.fiocruz.br/bitstream/icict/32941/2/Bystems%20Biology%20Reveals.pdf5b518dfab7392a0b1bef23b9c84f43bbMD52TEXTBystems Biology Reveals.pdf.txtBystems Biology Reveals.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
title Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
spellingShingle Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
Gomes, Juliana de Assis Silva
Doença de Chagas
Receptores Fc
Trypanosoma cruzi
Citocinas
Resposta imune
Chagas disease
Fc receptors
Trypanosoma cruzi
Cytokines
Immune response
title_short Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
title_full Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
title_fullStr Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
title_full_unstemmed Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
title_sort Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients
author Gomes, Juliana de Assis Silva
author_facet Gomes, Juliana de Assis Silva
Araújo, Fernanda Fortes de
Avelar, Daniele Marquete Vitelli
Avelar, Renato Sathler
Lage, Paula Souza
Wendling, Ana Paula Barbosa
Vale, Isabela Natalia Pascoal Campos do
Dias, João Carlos Pinto
Santos, Silvana Maria Elói
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
author_role author
author2 Araújo, Fernanda Fortes de
Avelar, Daniele Marquete Vitelli
Avelar, Renato Sathler
Lage, Paula Souza
Wendling, Ana Paula Barbosa
Vale, Isabela Natalia Pascoal Campos do
Dias, João Carlos Pinto
Santos, Silvana Maria Elói
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Juliana de Assis Silva
Araújo, Fernanda Fortes de
Avelar, Daniele Marquete Vitelli
Avelar, Renato Sathler
Lage, Paula Souza
Wendling, Ana Paula Barbosa
Vale, Isabela Natalia Pascoal Campos do
Dias, João Carlos Pinto
Santos, Silvana Maria Elói
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Receptores Fc
Trypanosoma cruzi
Citocinas
Resposta imune
topic Doença de Chagas
Receptores Fc
Trypanosoma cruzi
Citocinas
Resposta imune
Chagas disease
Fc receptors
Trypanosoma cruzi
Cytokines
Immune response
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Fc receptors
Trypanosoma cruzi
Cytokines
Immune response
description Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-05-06T13:03:30Z
dc.date.available.fl_str_mv 2019-05-06T13:03:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Juliana de Assis Silva et al. Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients. Frontiers in Microbiology, v. 9, p. 1-10, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32941
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2018.01608
identifier_str_mv GOMES, Juliana de Assis Silva et al. Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients. Frontiers in Microbiology, v. 9, p. 1-10, 2018.
1664-302X
10.3389/fmicb.2018.01608
url https://www.arca.fiocruz.br/handle/icict/32941
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32941/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32941/2/Bystems%20Biology%20Reveals.pdf
https://www.arca.fiocruz.br/bitstream/icict/32941/3/Bystems%20Biology%20Reveals.pdf.txt
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