Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs

Detalhes bibliográficos
Autor(a) principal: Leony, Leonardo Maia
Data de Publicação: 2019
Outros Autores: Freitas, Natália Erdens Maron de, Del-Rei, Rodrigo Pimenta, Carneiro, Claudia Martins, Reis, Alexandre Barbosa, Jansen, Ana Maria, Xavier, Samanta Cristina das Chagas, Gomes, Yara M., Silva, Edmilson D., Reis, Mitermayer Galvão dos, Fraga, Deborah Bittencourt Mothé, Celedon, Paola Alejandra Fiorani, Zanchin, Nilson I. T., Torres, Filipe Dantas, Santos, Fred Luciano Neves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34541
Resumo: Gonc¸alo Moniz Institute (Research Excellence Program - PROEP/IGM, Grant: 400904/2013-6; Internal Research Support Program - PIAP Jovem+, Grant: PIAP-001/2017), and in part by the Coordination of Superior Level Staff Improvement - Brazil (CAPES, Grant PROEX 0720/2018). Brazilian National Council for Scientific and Technological Development (CNPq) and Research Support Foundation for the State of Rio de Janeiro (FAPERJ). MGR, NITZ, CMC, ABR and AMJ are research fellows of CNPq. This study was funded by Oswaldo Cruz Foundation- FIOCRUZ; Vice- Presidency of Research and Reference Laboratories (VPPLR/FIOCRUZ) for investing in our research; the European Union Seventh Framework Program Grant 223034 – ChagasEpiNet.
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spelling Leony, Leonardo MaiaFreitas, Natália Erdens Maron deDel-Rei, Rodrigo PimentaCarneiro, Claudia MartinsReis, Alexandre BarbosaJansen, Ana MariaXavier, Samanta Cristina das ChagasGomes, Yara M.Silva, Edmilson D.Reis, Mitermayer Galvão dosFraga, Deborah Bittencourt MothéCeledon, Paola Alejandra FioraniZanchin, Nilson I. T.Torres, Filipe DantasSantos, Fred Luciano Neves2019-07-31T17:04:53Z2019-07-31T17:04:53Z2019LEONY, Leonardo Maia et al. Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. Plos Neglected Tropical Diseases, v. 13, n. 6, p. 1-16, 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3454110.1371/journal.pntd.0007545Gonc¸alo Moniz Institute (Research Excellence Program - PROEP/IGM, Grant: 400904/2013-6; Internal Research Support Program - PIAP Jovem+, Grant: PIAP-001/2017), and in part by the Coordination of Superior Level Staff Improvement - Brazil (CAPES, Grant PROEX 0720/2018). Brazilian National Council for Scientific and Technological Development (CNPq) and Research Support Foundation for the State of Rio de Janeiro (FAPERJ). MGR, NITZ, CMC, ABR and AMJ are research fellows of CNPq. This study was funded by Oswaldo Cruz Foundation- FIOCRUZ; Vice- Presidency of Research and Reference Laboratories (VPPLR/FIOCRUZ) for investing in our research; the European Union Seventh Framework Program Grant 223034 – ChagasEpiNet.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Faculty of Technology and Sciences of Bahia. Salvador, BA, Brazil.Federal University of Ouro Preto. Nucleus of Research in Biological Sciences. Immunopathology Laboratory. Ouro Preto, MG, Brazil.Federal University of Ouro Preto. Nucleus of Research in Biological Sciences. Immunopathology Laboratory. Ouro Preto, MG, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Immunobiological Technology Institute. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology and Legal Medicine. Salvador, BA, Brazil / Yale University. School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States of America.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exposure in humans. For human sera, these chimeric antigens presented superior diagnostic performances as compared to commercial tests available in Brazil, Spain, and Argentina. Therefore, in this study we have evaluated the potential of these antigenic proteins for detection of anti-T. cruzi IgG antibodies in dog sera.engPublic Library of ScienceTrypanosoma cruziProteinas quiméricasFatores de riscoTransmissãoCãesDiagnósticoTrypanosoma cruziChimeric ProteinsRisk factorsTransmissionDogsDiagnosisPerformance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34541/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLeony, L.M. Performance recombinant....2019.pdfLeony, L.M. 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dc.title.pt_BR.fl_str_mv Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
title Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
spellingShingle Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
Leony, Leonardo Maia
Trypanosoma cruzi
Proteinas quiméricas
Fatores de risco
Transmissão
Cães
Diagnóstico
Trypanosoma cruzi
Chimeric Proteins
Risk factors
Transmission
Dogs
Diagnosis
title_short Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
title_full Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
title_fullStr Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
title_full_unstemmed Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
title_sort Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs
author Leony, Leonardo Maia
author_facet Leony, Leonardo Maia
Freitas, Natália Erdens Maron de
Del-Rei, Rodrigo Pimenta
Carneiro, Claudia Martins
Reis, Alexandre Barbosa
Jansen, Ana Maria
Xavier, Samanta Cristina das Chagas
Gomes, Yara M.
Silva, Edmilson D.
Reis, Mitermayer Galvão dos
Fraga, Deborah Bittencourt Mothé
Celedon, Paola Alejandra Fiorani
Zanchin, Nilson I. T.
Torres, Filipe Dantas
Santos, Fred Luciano Neves
author_role author
author2 Freitas, Natália Erdens Maron de
Del-Rei, Rodrigo Pimenta
Carneiro, Claudia Martins
Reis, Alexandre Barbosa
Jansen, Ana Maria
Xavier, Samanta Cristina das Chagas
Gomes, Yara M.
Silva, Edmilson D.
Reis, Mitermayer Galvão dos
Fraga, Deborah Bittencourt Mothé
Celedon, Paola Alejandra Fiorani
Zanchin, Nilson I. T.
Torres, Filipe Dantas
Santos, Fred Luciano Neves
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leony, Leonardo Maia
Freitas, Natália Erdens Maron de
Del-Rei, Rodrigo Pimenta
Carneiro, Claudia Martins
Reis, Alexandre Barbosa
Jansen, Ana Maria
Xavier, Samanta Cristina das Chagas
Gomes, Yara M.
Silva, Edmilson D.
Reis, Mitermayer Galvão dos
Fraga, Deborah Bittencourt Mothé
Celedon, Paola Alejandra Fiorani
Zanchin, Nilson I. T.
Torres, Filipe Dantas
Santos, Fred Luciano Neves
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Proteinas quiméricas
Fatores de risco
Transmissão
Cães
Diagnóstico
topic Trypanosoma cruzi
Proteinas quiméricas
Fatores de risco
Transmissão
Cães
Diagnóstico
Trypanosoma cruzi
Chimeric Proteins
Risk factors
Transmission
Dogs
Diagnosis
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chimeric Proteins
Risk factors
Transmission
Dogs
Diagnosis
description Gonc¸alo Moniz Institute (Research Excellence Program - PROEP/IGM, Grant: 400904/2013-6; Internal Research Support Program - PIAP Jovem+, Grant: PIAP-001/2017), and in part by the Coordination of Superior Level Staff Improvement - Brazil (CAPES, Grant PROEX 0720/2018). Brazilian National Council for Scientific and Technological Development (CNPq) and Research Support Foundation for the State of Rio de Janeiro (FAPERJ). MGR, NITZ, CMC, ABR and AMJ are research fellows of CNPq. This study was funded by Oswaldo Cruz Foundation- FIOCRUZ; Vice- Presidency of Research and Reference Laboratories (VPPLR/FIOCRUZ) for investing in our research; the European Union Seventh Framework Program Grant 223034 – ChagasEpiNet.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-31T17:04:53Z
dc.date.available.fl_str_mv 2019-07-31T17:04:53Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEONY, Leonardo Maia et al. Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. Plos Neglected Tropical Diseases, v. 13, n. 6, p. 1-16, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34541
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007545
identifier_str_mv LEONY, Leonardo Maia et al. Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. Plos Neglected Tropical Diseases, v. 13, n. 6, p. 1-16, 2019.
1935-2727
10.1371/journal.pntd.0007545
url https://www.arca.fiocruz.br/handle/icict/34541
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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