Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?

Detalhes bibliográficos
Autor(a) principal: Schmaltz, Carolina Arana Stanis
Data de Publicação: 2019
Outros Autores: Demitto, Fernanda de Oliveira, Sant’Anna, Flavia Marinho, Rolla, Valeria Cavalcanti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32134
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.
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spelling Schmaltz, Carolina Arana StanisDemitto, Fernanda de OliveiraSant’Anna, Flavia MarinhoRolla, Valeria Cavalcanti2019-03-18T13:13:14Z2019-03-18T13:13:14Z2019SCHMALTZ, Carolina Arana Stanis et al. Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3213410.1590/0074-027601804201678-8060engInstituto Oswaldo CruzTuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Background: Rifamycins are a group of antibiotics mainly used in the treatment of tuberculosis (TB), however they interactwith antiretroviral therapy (ART). Rifabutin allows more regimens options for concomitant imunodeficiency virus (HIV) treatment compared to rifampicin. Objective: Compare the outcomes of TB-HIV co-infected patients who used rifampicin or rifabutin. Methods: We analysed data from a prospective cohort study at National Institute of Infectious Diseases Evandro Chagas, Rio de Janeiro (RJ), Brazil. Patients who were treated for TB and HIV with rifampicin or rifabutin, from February 2011 to September 2016 were included. Findings: There were 130 TB-HIV patients, of whom 102 were treated with rifampicin and 28 with rifabutin. All patients in the rifabutin-treated group and 55% of the rifampicin-treated group patients were ART-experienced. Patients treated with rifampicin had similar abandon and cure rates, interruptions in treatment due to adverse reactions, immune reconstitution inflammatory syndrome and a similar mortality rate as those treated with rifabutin. However, rifampicin-treated patients had higher CD4 counts and more frequently undetectable HIV viral load by the end of treatment (67% versus 18%, p < 0.001) compared to rifabutin-treated patients, even when only ART-experienced patients were evaluated (66,6% versus 36,3%, p = 0.039). Conclusion: Patients who used rifabutin had worst immune and virological control. This group had more ART-experienced patients. New and simpler regimens are needed for patients who do not respond to previous antiretroviral therapies.TuberculosisHIVRifampicinRifabutinRifamycinOutcomesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32134/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Schmaltz_Carolina_etal_INI_2019.pdfve_Schmaltz_Carolina_etal_INI_2019.pdfapplication/pdf267498https://www.arca.fiocruz.br/bitstream/icict/32134/2/ve_Schmaltz_Carolina_etal_INI_2019.pdfa48242f57f28c13aaa392afee8e9dcc8MD52TEXTve_Schmaltz_Carolina_etal_INI_2019.pdf.txtve_Schmaltz_Carolina_etal_INI_2019.pdf.txtExtracted texttext/plain25864https://www.arca.fiocruz.br/bitstream/icict/32134/3/ve_Schmaltz_Carolina_etal_INI_2019.pdf.txt257838d618ddca88f907dbd9059ecf68MD53icict/321342023-06-21 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dc.title.pt_BR.fl_str_mv Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
title Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
spellingShingle Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
Schmaltz, Carolina Arana Stanis
Tuberculosis
HIV
Rifampicin
Rifabutin
Rifamycin
Outcomes
title_short Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
title_full Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
title_fullStr Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
title_full_unstemmed Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
title_sort Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different?
author Schmaltz, Carolina Arana Stanis
author_facet Schmaltz, Carolina Arana Stanis
Demitto, Fernanda de Oliveira
Sant’Anna, Flavia Marinho
Rolla, Valeria Cavalcanti
author_role author
author2 Demitto, Fernanda de Oliveira
Sant’Anna, Flavia Marinho
Rolla, Valeria Cavalcanti
author2_role author
author
author
dc.contributor.author.fl_str_mv Schmaltz, Carolina Arana Stanis
Demitto, Fernanda de Oliveira
Sant’Anna, Flavia Marinho
Rolla, Valeria Cavalcanti
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
HIV
Rifampicin
Rifabutin
Rifamycin
Outcomes
topic Tuberculosis
HIV
Rifampicin
Rifabutin
Rifamycin
Outcomes
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-03-18T13:13:14Z
dc.date.available.fl_str_mv 2019-03-18T13:13:14Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHMALTZ, Carolina Arana Stanis et al. Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32134
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760180420
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SCHMALTZ, Carolina Arana Stanis et al. Tuberculosis-HIV treatment with Rifampicin or Rifabutin: are the outcomes different? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-5, 2019.
0074-0276
10.1590/0074-02760180420
1678-8060
url https://www.arca.fiocruz.br/handle/icict/32134
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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