EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019

Detalhes bibliográficos
Autor(a) principal: Spano, Liliana Cruz
Data de Publicação: 2021
Outros Autores: Guerrieri, Caroline Gastaldi, Volpini, Lays Paula Bondi, Schuenck, Ricardo Pinto, Goulart, Jaqueline Pegoretti, Boina, Elizabeth, Recco, Celia Regina Nascimento, Rodrigues, Rodrigo Ribeiro, Santos, Luís Fernando dos, Fumian, Tulio Machado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46908
Resumo: Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Maruipe, Vitória, ES, Brasil.
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spelling Spano, Liliana CruzGuerrieri, Caroline GastaldiVolpini, Lays Paula BondiSchuenck, Ricardo PintoGoulart, Jaqueline PegorettiBoina, ElizabethRecco, Celia Regina NascimentoRodrigues, Rodrigo RibeiroSantos, Luís Fernando dosFumian, Tulio Machado2021-04-26T15:08:10Z2021-04-26T15:08:10Z2021SPANO, Lilliana Cruz et al. EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019. BMC Microbiology, v. 21, n. 95, 9, 2021.1471-2180https://www.arca.fiocruz.br/handle/icict/4690810.1186/s12866-021-02161-xengBMCEscherichia coli enterohemorrágicaEscherichia coli Shiga-toxigênicaNorovírusSurtosSíndrome hemolítico-urêmicaCrecheEnterohemorrhagic Escherichia coliShiga-toxigenic Escherichia coliNorovirusOutbreaksHemolytic uremic syndromeChild daycare centerEHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Maruipe, Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Vitória, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Vitória, ES, Brasil.Secretaria Estadual de Saúde. Laboratório Central de Saúde Pública. Vitória, ES, Brasil.Secretaria Estadual de Saúde. Laboratório Central de Saúde Pública. Vitória, ES, Brasil.Secretaria Municipal de Saúde. Serviço de Epidemiologia. Vilha Velha, ES, Brasil.Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Vitória, ES, Brasil / Secretaria Estadual de Saúde. Laboratório Central de Saúde Pública. Vitória, ES, Brasil.Instituto Adolpho Lutz. Centro de Bacteriologia. Laboratório de Referência Nacional para infecções entéricas por Escherichia coli. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Background: This study describes the investigation of an outbreak of diarrhea, hemorrhagic colitis (HC), and hemolytic uremic syndrome (HUS) at a daycare center in southeastern Brazil, involving fourteen children, six staff members, six family members, and one nurse. All bacterial and viral pathogens detected were genetically characterized. Results: Two isolates of a strain of enterohemorrhagic Escherichia coli (EHEC) serotype O111:H8 were recovered, one implicated in a case of HUS and the other in a case of uncomplicated diarrhea. These isolates had a clonal relationship of 94% and carried the stx2a and eae virulence genes and the OI-122 pathogenicity island. The EHEC strain was determined to be a single-locus variant of sequence type (ST) 327. EHEC isolates were resistant to ofloxacin, doxycycline, tetracycline, ampicillin, and trimethoprim-sulfamethoxazole and intermediately resistant to levofloxacin and ciprofloxacin. Rotavirus was not detected in any samples, and norovirus was detected in 46.7% (14/30) of the stool samples, three of which were from asymptomatic staff members. The noroviruses were classified as the recombinant GII.4 Sydney [P16] by gene sequencing. Conclusion: In this outbreak, it was possible to identify an uncommon stx2a + EHEC O111:H8 strain, and the most recent pandemic norovirus strain GII.4 Sydney [P16]. Our findings reinforce the need for surveillance and diagnosis of multiple enteric pathogens by public health authorities, especially during outbreaks.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46908/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTulioMachado_Fumian_etal_IOC_2021.pdfTulioMachado_Fumian_etal_IOC_2021.pdfapplication/pdf1492805https://www.arca.fiocruz.br/bitstream/icict/46908/2/TulioMachado_Fumian_etal_IOC_2021.pdf1c4a6d0ec6104a86ab50492fa3d8e79cMD52TEXTTulioMachado_Fumian_etal_IOC_2021.pdf.txtTulioMachado_Fumian_etal_IOC_2021.pdf.txtExtracted texttext/plain47031https://www.arca.fiocruz.br/bitstream/icict/46908/3/TulioMachado_Fumian_etal_IOC_2021.pdf.txte12514384a03ee8ee2b7adac22fea165MD53icict/469082022-06-24 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dc.title.pt_BR.fl_str_mv EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
title EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
spellingShingle EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
Spano, Liliana Cruz
Escherichia coli enterohemorrágica
Escherichia coli Shiga-toxigênica
Norovírus
Surtos
Síndrome hemolítico-urêmica
Creche
Enterohemorrhagic Escherichia coli
Shiga-toxigenic Escherichia coli
Norovirus
Outbreaks
Hemolytic uremic syndrome
Child daycare center
title_short EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
title_full EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
title_fullStr EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
title_full_unstemmed EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
title_sort EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019
author Spano, Liliana Cruz
author_facet Spano, Liliana Cruz
Guerrieri, Caroline Gastaldi
Volpini, Lays Paula Bondi
Schuenck, Ricardo Pinto
Goulart, Jaqueline Pegoretti
Boina, Elizabeth
Recco, Celia Regina Nascimento
Rodrigues, Rodrigo Ribeiro
Santos, Luís Fernando dos
Fumian, Tulio Machado
author_role author
author2 Guerrieri, Caroline Gastaldi
Volpini, Lays Paula Bondi
Schuenck, Ricardo Pinto
Goulart, Jaqueline Pegoretti
Boina, Elizabeth
Recco, Celia Regina Nascimento
Rodrigues, Rodrigo Ribeiro
Santos, Luís Fernando dos
Fumian, Tulio Machado
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Spano, Liliana Cruz
Guerrieri, Caroline Gastaldi
Volpini, Lays Paula Bondi
Schuenck, Ricardo Pinto
Goulart, Jaqueline Pegoretti
Boina, Elizabeth
Recco, Celia Regina Nascimento
Rodrigues, Rodrigo Ribeiro
Santos, Luís Fernando dos
Fumian, Tulio Machado
dc.subject.other.pt_BR.fl_str_mv Escherichia coli enterohemorrágica
Escherichia coli Shiga-toxigênica
Norovírus
Surtos
Síndrome hemolítico-urêmica
Creche
topic Escherichia coli enterohemorrágica
Escherichia coli Shiga-toxigênica
Norovírus
Surtos
Síndrome hemolítico-urêmica
Creche
Enterohemorrhagic Escherichia coli
Shiga-toxigenic Escherichia coli
Norovirus
Outbreaks
Hemolytic uremic syndrome
Child daycare center
dc.subject.en.pt_BR.fl_str_mv Enterohemorrhagic Escherichia coli
Shiga-toxigenic Escherichia coli
Norovirus
Outbreaks
Hemolytic uremic syndrome
Child daycare center
description Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Patologia. Maruipe, Vitória, ES, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-26T15:08:10Z
dc.date.available.fl_str_mv 2021-04-26T15:08:10Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SPANO, Lilliana Cruz et al. EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019. BMC Microbiology, v. 21, n. 95, 9, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46908
dc.identifier.issn.pt_BR.fl_str_mv 1471-2180
dc.identifier.doi.none.fl_str_mv 10.1186/s12866-021-02161-x
identifier_str_mv SPANO, Lilliana Cruz et al. EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019. BMC Microbiology, v. 21, n. 95, 9, 2021.
1471-2180
10.1186/s12866-021-02161-x
url https://www.arca.fiocruz.br/handle/icict/46908
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
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