IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1989 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20418 |
Resumo: | Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Brodskyn, Claudia IdaSilva, Ana Maria Moura daTakehara, Harumi AndoAlbuquerque, Ivan da Mota e2017-07-26T18:38:42Z2017-07-26T18:38:42Z1989BRODSKYN, C. I. et al. IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunology and Cell Biology, v. 67, p. 343-348, 1989.0818-9641https://www.arca.fiocruz.br/handle/icict/20418Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Institulo Butantan. Immunology Research and Training Center. São Paulo, SP, BrazilInstitulo Butantan. Immunology Research and Training Center. São Paulo, SP, BrazilFederal University of Bahia. Health Sciences Institute. Laboratory of Immunology and Molecular Biology. Bioaggression Department. Salvador, BA, BrazilFederal University of Bahia. Health Sciences Institute. Laboratory of Immunology and Molecular Biology. Bioaggression Department. Salvador, BA, BrazilTo examine the role of different immunoglobulin subclasses in the immune clearance of Trypanosoma cruzi, mice containing bloodstream trypomastigotes were injeeted intravenously with immune serum, IgG-depleted serum, or with thelgGI or IgG2 fraelionsand the rateof removal of the parasites from circulation was determined. Using IgG concentrations similar to those found in the immune serum, the rate of clearanee mediated by IgG2 was six-fold higher than that obtained with IgGI. This differenee did not appear to be due to differences in antibody specificity, as Western blotting showed that each isotype recognized a similar set of antigens extracted from the parasite. However, the T. cruzi specific antibody content of the IgG2 was approximately five-fold higher than IgG I - When the dose of IgG was adjusted to equalize the antibody content, the clearance ability of the IgGI and IgG2 was very similar. It is concluded Ihat the two subclasses have a similar clearance ability.engNature Publishing GroupTrypanosoma cruziIgGSoroImunoglobulinaInfecçãoTrypanosoma cruziIgGSerumImmunoglobulinInfectionIgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20418/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrodskyn CI IgG subclasses responsible.....pdfBrodskyn CI IgG subclasses responsible.....pdfapplication/pdf2130506https://www.arca.fiocruz.br/bitstream/icict/20418/2/Brodskyn%20CI%20IgG%20subclasses%20responsible.....pdf03b71abfac8cfe75792d4dd319338f3eMD52TEXTBrodskyn CI IgG subclasses responsible.....pdf.txtBrodskyn CI IgG subclasses 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| dc.title.pt_BR.fl_str_mv |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| title |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| spellingShingle |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi Brodskyn, Claudia Ida Trypanosoma cruzi IgG Soro Imunoglobulina Infecção Trypanosoma cruzi IgG Serum Immunoglobulin Infection |
| title_short |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| title_full |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| title_fullStr |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| title_full_unstemmed |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| title_sort |
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi |
| author |
Brodskyn, Claudia Ida |
| author_facet |
Brodskyn, Claudia Ida Silva, Ana Maria Moura da Takehara, Harumi Ando Albuquerque, Ivan da Mota e |
| author_role |
author |
| author2 |
Silva, Ana Maria Moura da Takehara, Harumi Ando Albuquerque, Ivan da Mota e |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Brodskyn, Claudia Ida Silva, Ana Maria Moura da Takehara, Harumi Ando Albuquerque, Ivan da Mota e |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi IgG Soro Imunoglobulina Infecção |
| topic |
Trypanosoma cruzi IgG Soro Imunoglobulina Infecção Trypanosoma cruzi IgG Serum Immunoglobulin Infection |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi IgG Serum Immunoglobulin Infection |
| description |
Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
| publishDate |
1989 |
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1989 |
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2017-07-26T18:38:42Z |
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2017-07-26T18:38:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
BRODSKYN, C. I. et al. IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunology and Cell Biology, v. 67, p. 343-348, 1989. |
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https://www.arca.fiocruz.br/handle/icict/20418 |
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0818-9641 |
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BRODSKYN, C. I. et al. IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunology and Cell Biology, v. 67, p. 343-348, 1989. 0818-9641 |
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Nature Publishing Group |
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