Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid

Detalhes bibliográficos
Autor(a) principal: Silva, G. P.
Data de Publicação: 2013
Outros Autores: Cruz, S. C., Cruz, A. C., Milagres, L. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36159
Resumo: Simone da Costa Cruz Silva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Silva, G. P.Cruz, S. C.Cruz, A. C.Milagres, L. G.2019-10-04T11:50:28Z2019-10-04T11:50:28Z2013SILVA, G. P. et al. Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid. Brazilian Journal of Medical and Biological Research, v. 46, p. 148-153, 2013.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/3615910.1590/1414-431X201225561414-431XSimone da Costa Cruz Silva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Serogroup B Neisseria meningitidis (MenB) is a major cause of invasive disease in early childhood worldwide. The only MenB vaccine available in Brazil was produced in Cuba and has shown unsatisfactory efficacy when used to immunize millions of children in Brazil. In the present study, we compared the specific functional antibody responses evoked by the Cuban MenB vaccine with a standard vaccine against diphtheria (DTP: diphtheria, tetanus, pertussis) after primary immunization and boosting of mice. The peak of bactericidal and opsonic antibody titers to MenB and of neutralizing antibodies to diphtheria toxoid (DT) was reached after triple immunization with the MenB vaccine or DTP vaccine, respectively. However, 4 months after immunization, protective DT antibody levels were present in all DTP-vaccinated mice but in only 20% of the mice immunized against MenB. After 6 months of primary immunization, about 70% of animals still had protective neutralizing DT antibodies, but none had significant bactericidal antibodies to MenB. The booster doses of DTP or MenB vaccines produced a significant antibody recall response, suggesting that both vaccines were able to generate and maintain memory B cells during the period studied (6 months post-triple immunization). Therefore, due to the short duration of serological memory induced by the MenB vaccine (VA-MENGOC-BCH vaccine), its use should be restricted to outbreaks of meningococcal disease.engAssociação Brasileira de Divulgação CientíficaShort-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSerological memoryAntibody recall responseBooster immunizationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36159/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Silva_G_etal_INI_2013.pdfve_Silva_G_etal_INI_2013.pdfapplication/pdf604009https://www.arca.fiocruz.br/bitstream/icict/36159/2/ve_Silva_G_etal_INI_2013.pdfd173ec9c7517970e5dc1d324fe30cab0MD52TEXTve_Silva_G_etal_INI_2013.pdf.txtve_Silva_G_etal_INI_2013.pdf.txtExtracted texttext/plain26303https://www.arca.fiocruz.br/bitstream/icict/36159/3/ve_Silva_G_etal_INI_2013.pdf.txtf78bf2ac974e3a2dd34d1783cc587e27MD53icict/361592019-10-06 11:10:06.333oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-06T14:10:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
title Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
spellingShingle Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
Silva, G. P.
Serological memory
Antibody recall response
Booster immunization
title_short Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
title_full Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
title_fullStr Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
title_full_unstemmed Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
title_sort Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
author Silva, G. P.
author_facet Silva, G. P.
Cruz, S. C.
Cruz, A. C.
Milagres, L. G.
author_role author
author2 Cruz, S. C.
Cruz, A. C.
Milagres, L. G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, G. P.
Cruz, S. C.
Cruz, A. C.
Milagres, L. G.
dc.subject.en.pt_BR.fl_str_mv Serological memory
Antibody recall response
Booster immunization
topic Serological memory
Antibody recall response
Booster immunization
description Simone da Costa Cruz Silva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2019-10-04T11:50:28Z
dc.date.available.fl_str_mv 2019-10-04T11:50:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, G. P. et al. Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid. Brazilian Journal of Medical and Biological Research, v. 46, p. 148-153, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36159
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/1414-431X20122556
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv SILVA, G. P. et al. Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid. Brazilian Journal of Medical and Biological Research, v. 46, p. 148-153, 2013.
0100-879X
10.1590/1414-431X20122556
1414-431X
url https://www.arca.fiocruz.br/handle/icict/36159
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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