The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.

Detalhes bibliográficos
Autor(a) principal: Soares, Milena Botelho Pereira
Data de Publicação: 2001
Outros Autores: Pontes-de-Carvalho, Lain Carlos, Santos, Ricardo Ribeiro dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5508
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Soares, Milena Botelho PereiraPontes-de-Carvalho, Lain CarlosSantos, Ricardo Ribeiro dos2012-09-11T19:14:10Z2012-09-11T19:14:10Z2001SOARES, M.B.; PONTES-DE-CARVALHO, L.; RIBEIRO-DOS-SANTOS, R. The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet. Anais da Academia Brasileira de Ciencias, v. 73, n. 4, p. 547-59, dez. 2001.0001-3765https://www.arca.fiocruz.br/handle/icict/5508engThe pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilChagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites or parasite antigens is suggested, by some authors, as the pathogenic mechanism of CChC. Other researchers affirm that the lack of correlation between tissue parasitism and intensity of inflammation suggests, along with the presence of autoreactive immune responses, that CChC results from the action of an autoimmune response. Herein we review reports from the literature and our own data, which together indicate, on one hand, the participation of parasite-specific immune responses and, on the other hand, clearly demonstrate the participation of heart-specific immune responses in the pathogenesis of CChC. Moreover, multiple factors may determine whether an individual in the indeterminate form of the disease will develop CChC. The mechanisms by which T. cruzi breaks immunological tolerance to heart antigens are also discussed.Chagas’ diseasemyocarditis,AutoimmunityTrypanosoma cruziDdelayed-type hypersensitivityAuto-ImunidadeCardiomiopatia Chagásica/imunologiaTrypanosoma cruzi/imunologiaAnimaisCardiomiopatia Chagásica/patologiaDoença CrônicaHumanosHipersensibilidade Tardia/imunologiaTolerância ImunológicaCamundongosFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares MB The pathogenesis of Chagas' ....pdfSoares MB The pathogenesis of Chagas' ....pdfapplication/pdf677235https://www.arca.fiocruz.br/bitstream/icict/5508/1/Soares%20MB%20The%20pathogenesis%20of%20Chagas%27%20....pdfebff97d0b8f0bfdd23cc32596e0544f0MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5508/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSoares MB The pathogenesis of Chagas' ....pdf.txtSoares MB The pathogenesis of Chagas' ....pdf.txtExtracted texttext/plain44737https://www.arca.fiocruz.br/bitstream/icict/5508/5/Soares%20MB%20The%20pathogenesis%20of%20Chagas%27%20....pdf.txtdf703653c3c80a9e83c9e8ba5a4af654MD55THUMBNAILSoares MB The pathogenesis of Chagas' ....pdf.jpgSoares MB The pathogenesis of Chagas' ....pdf.jpgGenerated Thumbnailimage/jpeg1769https://www.arca.fiocruz.br/bitstream/icict/5508/4/Soares%20MB%20The%20pathogenesis%20of%20Chagas%27%20....pdf.jpgc2b4ef192f4aeffd0aee6ad973f81270MD54icict/55082023-03-15 14:32:53.963oai:www.arca.fiocruz.br:icict/5508TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
title The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
spellingShingle The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
Soares, Milena Botelho Pereira
Chagas’ disease
myocarditis,
Autoimmunity
Trypanosoma cruzi
Ddelayed-type hypersensitivity
Auto-Imunidade
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Cardiomiopatia Chagásica/patologia
Doença Crônica
Humanos
Hipersensibilidade Tardia/imunologia
Tolerância Imunológica
Camundongos
Fatores de Tempo
title_short The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
title_full The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
title_fullStr The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
title_full_unstemmed The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
title_sort The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet.
author Soares, Milena Botelho Pereira
author_facet Soares, Milena Botelho Pereira
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
author_role author
author2 Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
author2_role author
author
dc.contributor.author.fl_str_mv Soares, Milena Botelho Pereira
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
dc.subject.en.pt_BR.fl_str_mv Chagas’ disease
myocarditis,
Autoimmunity
Trypanosoma cruzi
Ddelayed-type hypersensitivity
topic Chagas’ disease
myocarditis,
Autoimmunity
Trypanosoma cruzi
Ddelayed-type hypersensitivity
Auto-Imunidade
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Cardiomiopatia Chagásica/patologia
Doença Crônica
Humanos
Hipersensibilidade Tardia/imunologia
Tolerância Imunológica
Camundongos
Fatores de Tempo
dc.subject.decs.pt_BR.fl_str_mv Auto-Imunidade
Cardiomiopatia Chagásica/imunologia
Trypanosoma cruzi/imunologia
Animais
Cardiomiopatia Chagásica/patologia
Doença Crônica
Humanos
Hipersensibilidade Tardia/imunologia
Tolerância Imunológica
Camundongos
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-09-11T19:14:10Z
dc.date.available.fl_str_mv 2012-09-11T19:14:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, M.B.; PONTES-DE-CARVALHO, L.; RIBEIRO-DOS-SANTOS, R. The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet. Anais da Academia Brasileira de Ciencias, v. 73, n. 4, p. 547-59, dez. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5508
dc.identifier.issn.none.fl_str_mv 0001-3765
identifier_str_mv SOARES, M.B.; PONTES-DE-CARVALHO, L.; RIBEIRO-DOS-SANTOS, R. The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet. Anais da Academia Brasileira de Ciencias, v. 73, n. 4, p. 547-59, dez. 2001.
0001-3765
url https://www.arca.fiocruz.br/handle/icict/5508
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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