Authophagy as a target for drug development of skin infection caused by Mycobacteria

Detalhes bibliográficos
Autor(a) principal: Bittencourt, Tamiris Lameira
Data de Publicação: 2021
Outros Autores: Prata, Rhana Berto da Silva, Silva, Bruno Jorge de Andrade, Barbosa, Mayara Garcia de Mattos, Dalcomo, Margareth Pretti, Pinheiro, Roberta Olmo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/48204
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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spelling Bittencourt, Tamiris LameiraPrata, Rhana Berto da SilvaSilva, Bruno Jorge de AndradeBarbosa, Mayara Garcia de MattosDalcomo, Margareth PrettiPinheiro, Roberta Olmo2021-07-13T11:50:45Z2021-07-13T11:50:45Z2021BITTENCOURT, Tamiris Ladeira et al. Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria. Front. Immunol., v. 12, Article 674241, 14 p, May 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/4820410.3389/fimmu.2021.674241engFrontiers MediaAutofagiaPeleMicobactériasDesenvolvimento de drogasCélulas da peleAutophagySkinMycobacteriaDrug developmentSkin cellsAuthophagy as a target for drug development of skin infection caused by Mycobacteriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.David Geffen School of Medicine. Division of Dermatology. Los Angeles, CA, United States.University of Michigan, Ann Arbor. Department of Surgery. Ann Arbor, MI, United States.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Referência Helio Fraga. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Pathogenic mycobacteria species may subvert the innate immune mechanisms and can modulate the activation of cells that cause disease in the skin. Cutaneous mycobacterial infection may present different clinical presentations and it is associated with stigma, deformity, and disability. The understanding of the immunopathogenic mechanisms related to mycobacterial infection in human skin is of pivotal importance to identify targets for new therapeutic strategies. The occurrence of reactional episodes and relapse in leprosy patients, the emergence of resistant mycobacteria strains, and the absence of effective drugs to treat mycobacterial cutaneous infection increased the interest in the development of therapies based on repurposed drugs against mycobacteria. The mechanism of action of many of these therapies evaluated is linked to the activation of autophagy. Autophagy is an evolutionary conserved lysosomal degradation pathway that has been associated with the control of the mycobacterial bacillary load. Here, we review the role of autophagy in the pathogenesis of cutaneous mycobacterial infection and discuss the perspectives of autophagy as a target for drug development and repurposing against cutaneous mycobacterial infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/48204/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdfTamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdfapplication/pdf15345985https://www.arca.fiocruz.br/bitstream/icict/48204/2/TamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdfa541314fa51133455df918b98403e762MD52TEXTTamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdf.txtTamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Authophagy as a target for drug development of skin infection caused by Mycobacteria
title Authophagy as a target for drug development of skin infection caused by Mycobacteria
spellingShingle Authophagy as a target for drug development of skin infection caused by Mycobacteria
Bittencourt, Tamiris Lameira
Autofagia
Pele
Micobactérias
Desenvolvimento de drogas
Células da pele
Autophagy
Skin
Mycobacteria
Drug development
Skin cells
title_short Authophagy as a target for drug development of skin infection caused by Mycobacteria
title_full Authophagy as a target for drug development of skin infection caused by Mycobacteria
title_fullStr Authophagy as a target for drug development of skin infection caused by Mycobacteria
title_full_unstemmed Authophagy as a target for drug development of skin infection caused by Mycobacteria
title_sort Authophagy as a target for drug development of skin infection caused by Mycobacteria
author Bittencourt, Tamiris Lameira
author_facet Bittencourt, Tamiris Lameira
Prata, Rhana Berto da Silva
Silva, Bruno Jorge de Andrade
Barbosa, Mayara Garcia de Mattos
Dalcomo, Margareth Pretti
Pinheiro, Roberta Olmo
author_role author
author2 Prata, Rhana Berto da Silva
Silva, Bruno Jorge de Andrade
Barbosa, Mayara Garcia de Mattos
Dalcomo, Margareth Pretti
Pinheiro, Roberta Olmo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bittencourt, Tamiris Lameira
Prata, Rhana Berto da Silva
Silva, Bruno Jorge de Andrade
Barbosa, Mayara Garcia de Mattos
Dalcomo, Margareth Pretti
Pinheiro, Roberta Olmo
dc.subject.other.pt_BR.fl_str_mv Autofagia
Pele
Micobactérias
Desenvolvimento de drogas
Células da pele
topic Autofagia
Pele
Micobactérias
Desenvolvimento de drogas
Células da pele
Autophagy
Skin
Mycobacteria
Drug development
Skin cells
dc.subject.en.pt_BR.fl_str_mv Autophagy
Skin
Mycobacteria
Drug development
Skin cells
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-07-13T11:50:45Z
dc.date.available.fl_str_mv 2021-07-13T11:50:45Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BITTENCOURT, Tamiris Ladeira et al. Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria. Front. Immunol., v. 12, Article 674241, 14 p, May 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/48204
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2021.674241
identifier_str_mv BITTENCOURT, Tamiris Ladeira et al. Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria. Front. Immunol., v. 12, Article 674241, 14 p, May 2021.
1664-3224
10.3389/fimmu.2021.674241
url https://www.arca.fiocruz.br/handle/icict/48204
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/48204/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/48204/3/TamirisBittencourt_MargarethDalcomo_etal_IOC_2021.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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