Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women

Detalhes bibliográficos
Autor(a) principal: Cruz, Maria Letícia
Data de Publicação: 2016
Outros Autores: Santos, Edwiges, Benamor Teixeira, Maria de Lourdes, Poletti, Monica, Sousa, Carolina, Gouvea, Maria Isabel, Nielsen-Saines, Karin, João, Esaú
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32452
Resumo: Maria Isabel Fragoso da Silveira Gouvêa. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Cruz, Maria LetíciaSantos, EdwigesBenamor Teixeira, Maria de LourdesPoletti, MonicaSousa, CarolinaGouvea, Maria IsabelNielsen-Saines, KarinJoão, Esaú2019-04-11T13:02:17Z2019-04-11T13:02:17Z2016CRUZ, Maria Letícia et al. Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women. International Journal of Environmental Research and Public Health, v. 13, n. 568, p. 1-6, 2016.1661-7827https://www.arca.fiocruz.br/handle/icict/3245210.3390/ijerph130605681660-4601Maria Isabel Fragoso da Silveira Gouvêa. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.University of California. David Geffen School of Medicine. Los Angeles, CA, USA.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Our objective was to describe viral suppression and antiretroviral (ARV) resistance mutations in an ongoing cohort of perinatally-infected HIV+ (PHIV+) pregnant women. Descriptive analysis was performed using SPSS 18.0. From 2011 to 2014, we followed 22 PHIV+ pregnant women. Median age at prenatal entry was 19 years (Interquartile range (IQR) 17.6-21.0); 86% had an AIDS diagnosis; 81% had disclosed their HIV status to partner 11. The median age at HIV diagnosis was 8.3 y (IQR 4.0-13.6), the median age at sexual debut was 16 years (IQR 14-18). At the time of prenatal care initiation, four (18%) were on their first antiretroviral treatment (ART), eight (36%) in their second regimen and nine (41%) in their third regimen or beyond, and one had no data. Seventeen of 22 (77%) had HIV-viral load (VL) > 50 copies/mL at prenatal care entry, 16 had a genotyping exam performed. Seventeen of 22 PHIV+ had VL results near delivery: 7/17 (41%) had VL < 50 copies/mL. Among those who had genotyping at prenatal entry, 11/16 (69%) had mutations associated with ARV resistance. The most frequent major mutations were K103N, M184V, T215, M41L, D67N at reverse transcriptase gene and M46, I54V and V82A at protease gene. No vertical transmissions occurred. Management of pregnancy among PHIV+ is challenging. Individualized ART are needed to achieve viral suppression in a highly ART-exposed subpopulation.engMDPIViral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIV infectionPregnant womenVertical infection transmissionDrug resistanceMutationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32452/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Cruz_Maria_etal_INI_2016.pdfve_Cruz_Maria_etal_INI_2016.pdfapplication/pdf256405https://www.arca.fiocruz.br/bitstream/icict/32452/2/ve_Cruz_Maria_etal_INI_2016.pdf928a217be0bb8bf1f41e2c69142ebb0dMD52TEXTve_Cruz_Maria_etal_INI_2016.pdf.txtve_Cruz_Maria_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
title Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
spellingShingle Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
Cruz, Maria Letícia
HIV infection
Pregnant women
Vertical infection transmission
Drug resistance
Mutation
title_short Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
title_full Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
title_fullStr Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
title_full_unstemmed Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
title_sort Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women
author Cruz, Maria Letícia
author_facet Cruz, Maria Letícia
Santos, Edwiges
Benamor Teixeira, Maria de Lourdes
Poletti, Monica
Sousa, Carolina
Gouvea, Maria Isabel
Nielsen-Saines, Karin
João, Esaú
author_role author
author2 Santos, Edwiges
Benamor Teixeira, Maria de Lourdes
Poletti, Monica
Sousa, Carolina
Gouvea, Maria Isabel
Nielsen-Saines, Karin
João, Esaú
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Maria Letícia
Santos, Edwiges
Benamor Teixeira, Maria de Lourdes
Poletti, Monica
Sousa, Carolina
Gouvea, Maria Isabel
Nielsen-Saines, Karin
João, Esaú
dc.subject.en.pt_BR.fl_str_mv HIV infection
Pregnant women
Vertical infection transmission
Drug resistance
Mutation
topic HIV infection
Pregnant women
Vertical infection transmission
Drug resistance
Mutation
description Maria Isabel Fragoso da Silveira Gouvêa. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-11T13:02:17Z
dc.date.available.fl_str_mv 2019-04-11T13:02:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Maria Letícia et al. Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women. International Journal of Environmental Research and Public Health, v. 13, n. 568, p. 1-6, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32452
dc.identifier.issn.pt_BR.fl_str_mv 1661-7827
dc.identifier.doi.none.fl_str_mv 10.3390/ijerph13060568
dc.identifier.eissn.none.fl_str_mv 1660-4601
identifier_str_mv CRUZ, Maria Letícia et al. Viral suppression and resistance in a cohort of perinatally-HIV infected (PHIV+) pregnant women. International Journal of Environmental Research and Public Health, v. 13, n. 568, p. 1-6, 2016.
1661-7827
10.3390/ijerph13060568
1660-4601
url https://www.arca.fiocruz.br/handle/icict/32452
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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