Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/7977 http://dx.doi.org/10.1016/j.jped.2014.12.005 |
Resumo: | Aim: To compare the prevalence and factors associated with vertical transmission of HIV-1 among pregnant women treated in the periods of 1998---2004 and 2005---2011 in a reference service for the care of HIV-infected patients in southern Brazil. Methods: A descriptive and analytical study which used the databases of laboratories of Viral Load and CD4 National Laboratory Network of STD/AIDS, Ministry of Health. HIV-1 infected pregnant women were selected following an active search for clinical information and obstetric and neonatal data from their medical records between the years 1998 and 2011. Results: 102 pregnant women were analyzed between 1998 and 2004 and 251 in the period 2005---2011 totaling 353 children born to pregnant women with HIV-1. It was observed that vertical transmission was 11.8% between 1998 and 2004 and 3.2% between 2005 and 2011 (p < 0.001). The increased use of antiretroviral drugs (p = 0.02), the decrease in viral load (p < 0.001) and time of rupture of membranes lower than 4 h (p < 0.001) were associated with the decrease of vertical transmission factors when comparing the two periods. Conclusion: It was observed a decrease in the rate of vertical transmission in recent years. According to the studied variables, is suggested that the risk factors for vertical transmission of HIV-1 were absence of antiretroviral therapy, high viral load of pregnant women and the breakthrough time greater than 4 h membranes. |
id |
FURG_9464da84184aeb6702be02594103f081 |
---|---|
oai_identifier_str |
oai:repositorio.furg.br:1/7977 |
network_acronym_str |
FURG |
network_name_str |
Repositório Institucional da FURG (RI FURG) |
repository_id_str |
|
spelling |
Rosa, Matheus Costa daLobato, Rubens CaurioGonçalves, Carla VitolaSilva, Naylê Maria Oliveira daBarral, Maria Fernanda MartínezMartinez, Ana Maria Barral deHora, Vanusa Pousada da2019-08-15T20:48:47Z2019-08-15T20:48:47Z2015ROSA, Matheus Costa da et al. Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil. Jornal de Pediatria, v. 91, n. 6, p. 523-528, 2015. Disponível em:<https://www.researchgate.net/profile/Vanusa_Pousada_da_Hora2/publication/279461232_Evaluation_of_factors_associated_with_vertical_HIV-1_transmission/links/559ebbf308aeffab5687c91c.pdf?origin=publication_list>. Acesso em: 17 nov. 2016.0021-7557http://repositorio.furg.br/handle/1/7977http://dx.doi.org/10.1016/j.jped.2014.12.005Aim: To compare the prevalence and factors associated with vertical transmission of HIV-1 among pregnant women treated in the periods of 1998---2004 and 2005---2011 in a reference service for the care of HIV-infected patients in southern Brazil. Methods: A descriptive and analytical study which used the databases of laboratories of Viral Load and CD4 National Laboratory Network of STD/AIDS, Ministry of Health. HIV-1 infected pregnant women were selected following an active search for clinical information and obstetric and neonatal data from their medical records between the years 1998 and 2011. Results: 102 pregnant women were analyzed between 1998 and 2004 and 251 in the period 2005---2011 totaling 353 children born to pregnant women with HIV-1. It was observed that vertical transmission was 11.8% between 1998 and 2004 and 3.2% between 2005 and 2011 (p < 0.001). The increased use of antiretroviral drugs (p = 0.02), the decrease in viral load (p < 0.001) and time of rupture of membranes lower than 4 h (p < 0.001) were associated with the decrease of vertical transmission factors when comparing the two periods. Conclusion: It was observed a decrease in the rate of vertical transmission in recent years. According to the studied variables, is suggested that the risk factors for vertical transmission of HIV-1 were absence of antiretroviral therapy, high viral load of pregnant women and the breakthrough time greater than 4 h membranes.engElsevierHuman immunodeficiency virus type 1Vertical infection transmissionPregnant womanEvaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern BrazilAvaliação dos fatores associados à transmissão vertical do HIV-1 em quatorze anos de um centro de referência no Sul do Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGORIGINALEvaluation_of_factors_associated_with_vertical_HIV.pdfEvaluation_of_factors_associated_with_vertical_HIV.pdfapplication/pdf352047https://repositorio.furg.br/bitstream/1/7977/1/Evaluation_of_factors_associated_with_vertical_HIV.pdf81c972ebe384cfb17322759264f6fa7bMD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.furg.br/bitstream/1/7977/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open access1/79772019-08-15 17:48:47.537open accessoai:repositorio.furg.br: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Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2019-08-15T20:48:47Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
dc.title.alternative.pt_BR.fl_str_mv |
Avaliação dos fatores associados à transmissão vertical do HIV-1 em quatorze anos de um centro de referência no Sul do Brasil |
title |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
spellingShingle |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil Rosa, Matheus Costa da Human immunodeficiency virus type 1 Vertical infection transmission Pregnant woman |
title_short |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
title_full |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
title_fullStr |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
title_full_unstemmed |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
title_sort |
Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil |
author |
Rosa, Matheus Costa da |
author_facet |
Rosa, Matheus Costa da Lobato, Rubens Caurio Gonçalves, Carla Vitola Silva, Naylê Maria Oliveira da Barral, Maria Fernanda Martínez Martinez, Ana Maria Barral de Hora, Vanusa Pousada da |
author_role |
author |
author2 |
Lobato, Rubens Caurio Gonçalves, Carla Vitola Silva, Naylê Maria Oliveira da Barral, Maria Fernanda Martínez Martinez, Ana Maria Barral de Hora, Vanusa Pousada da |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rosa, Matheus Costa da Lobato, Rubens Caurio Gonçalves, Carla Vitola Silva, Naylê Maria Oliveira da Barral, Maria Fernanda Martínez Martinez, Ana Maria Barral de Hora, Vanusa Pousada da |
dc.subject.por.fl_str_mv |
Human immunodeficiency virus type 1 Vertical infection transmission Pregnant woman |
topic |
Human immunodeficiency virus type 1 Vertical infection transmission Pregnant woman |
description |
Aim: To compare the prevalence and factors associated with vertical transmission of HIV-1 among pregnant women treated in the periods of 1998---2004 and 2005---2011 in a reference service for the care of HIV-infected patients in southern Brazil. Methods: A descriptive and analytical study which used the databases of laboratories of Viral Load and CD4 National Laboratory Network of STD/AIDS, Ministry of Health. HIV-1 infected pregnant women were selected following an active search for clinical information and obstetric and neonatal data from their medical records between the years 1998 and 2011. Results: 102 pregnant women were analyzed between 1998 and 2004 and 251 in the period 2005---2011 totaling 353 children born to pregnant women with HIV-1. It was observed that vertical transmission was 11.8% between 1998 and 2004 and 3.2% between 2005 and 2011 (p < 0.001). The increased use of antiretroviral drugs (p = 0.02), the decrease in viral load (p < 0.001) and time of rupture of membranes lower than 4 h (p < 0.001) were associated with the decrease of vertical transmission factors when comparing the two periods. Conclusion: It was observed a decrease in the rate of vertical transmission in recent years. According to the studied variables, is suggested that the risk factors for vertical transmission of HIV-1 were absence of antiretroviral therapy, high viral load of pregnant women and the breakthrough time greater than 4 h membranes. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2019-08-15T20:48:47Z |
dc.date.available.fl_str_mv |
2019-08-15T20:48:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ROSA, Matheus Costa da et al. Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil. Jornal de Pediatria, v. 91, n. 6, p. 523-528, 2015. Disponível em:<https://www.researchgate.net/profile/Vanusa_Pousada_da_Hora2/publication/279461232_Evaluation_of_factors_associated_with_vertical_HIV-1_transmission/links/559ebbf308aeffab5687c91c.pdf?origin=publication_list>. Acesso em: 17 nov. 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.furg.br/handle/1/7977 |
dc.identifier.issn.none.fl_str_mv |
0021-7557 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1016/j.jped.2014.12.005 |
identifier_str_mv |
ROSA, Matheus Costa da et al. Evaluation of factors associated with vertical transmission of HIV-1 in fourteen years of a referral center in Southern Brazil. Jornal de Pediatria, v. 91, n. 6, p. 523-528, 2015. Disponível em:<https://www.researchgate.net/profile/Vanusa_Pousada_da_Hora2/publication/279461232_Evaluation_of_factors_associated_with_vertical_HIV-1_transmission/links/559ebbf308aeffab5687c91c.pdf?origin=publication_list>. Acesso em: 17 nov. 2016. 0021-7557 |
url |
http://repositorio.furg.br/handle/1/7977 http://dx.doi.org/10.1016/j.jped.2014.12.005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
instacron_str |
FURG |
institution |
FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
bitstream.url.fl_str_mv |
https://repositorio.furg.br/bitstream/1/7977/1/Evaluation_of_factors_associated_with_vertical_HIV.pdf https://repositorio.furg.br/bitstream/1/7977/2/license.txt |
bitstream.checksum.fl_str_mv |
81c972ebe384cfb17322759264f6fa7b 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
repository.mail.fl_str_mv |
|
_version_ |
1798313650206801920 |