Fatal encephalitis associated with Zika virus infection in an adult

Detalhes bibliográficos
Autor(a) principal: Soares, Cristiane N.
Data de Publicação: 2016
Outros Autores: Brasil, Patrícia, Carrera, Raquel Medialdea, Sequeira, Patricia, Filippis, Ana Maria Bispo de, Borges, Vitor A., Theophilo, Fernando, Ellul, Mark A., Solomon, Tom
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15791
Resumo: Hospital Federal dos Servidores do Estado. Serviço de Neurologia. Rio de Janeiro, RJ, Brasil.
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spelling Soares, Cristiane N.Brasil, PatríciaCarrera, Raquel MedialdeaSequeira, PatriciaFilippis, Ana Maria Bispo deBorges, Vitor A.Theophilo, FernandoEllul, Mark A.Solomon, Tom2016-09-14T15:16:45Z2016-09-14T15:16:45Z2016SOARES, Cristiane N. et al. Fatal encephalitis associated with Zika virus infection in an adult. Journal of Clinical Virology, v.83, p.63-65, 2016.1386-6532https://www.arca.fiocruz.br/handle/icict/1579110.1016/j.jcv.2016.08.297engElsevierZika virusEncefaliteManifestações neurológicasZika virusEncephalitisNeurological manifestationsFatal encephalitis associated with Zika virus infection in an adultinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Federal dos Servidores do Estado. Serviço de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Liverpool. Institute of Infection and Global health. Liverpool, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Hospital Badim. Rio de Janeiro, RJ, Brasil.Hospital Badim. Rio de Janeiro, RJ, Brasil.University of Liverpool. Institute of Infection and Global Health. Liverpool, UK / University of Liverpool. Health Protection Research unit in Emerging and Zoonotic Infections. Liverpool, UK / Walton Centre NHS Foundation Trust. Liverpool, UK.University of Liverpool. Institute of Infection and Global Health. Liverpool, UK / University of Liverpool. Health Protection Research unit in Emerging and Zoonotic Infections. Liverpool, UK / Walton Centre NHS Foundation Trust. Liverpool, UK.Background: Zika virus (ZIKV) was first identified in the Americas in 2015, when an outbreak of an exanthematous illness occurred in Brazil. Subsequentely, there was an increase of microcephaly cases, suggesting an association between ZIKV and this neurological complication. Currently, ZIKV has been recognised as causing a wide range of neurological complications including Guillain Barré syndrome, and myelitis. Objectives: In this report, we describe the first fatal case of encephalitis in a 47 years old non pregnant woman, infected during the Brazilian zika epidemic of 2016. Study design: The diagnosis of encephalitis was determined by the presence of a disturbed level of consciousness and focal neurological signs during an exanthemous viral infection. Results: CSF analysis supported the diagnosis of viral encephalitis, revealing lymphocytic pleocytosis, a high protein concentration, and the presence of IgM zika antibodies. RT-PCR analysis for ZIKV was positive in the urine. A brain computed tomography showed massive brain swelling. Our case differs from previous reports, because her neurological picture developed rapidly and in a very aggressive manner leading to brain death after eleven days of admission. Conclusion: In endemic areas, ZIKV should be considered as an aetiological agent in cases of encephalitis, and clinicians should be aware of its potential severity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15791/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALana_fillipis_etal_IOC_2016.pdfana_fillipis_etal_IOC_2016.pdfapplication/pdf454478https://www.arca.fiocruz.br/bitstream/icict/15791/2/ana_fillipis_etal_IOC_2016.pdfb5addd55c12b44796b30bc0b3a0734c9MD52TEXTana_fillipis_etal_IOC_2016.pdf.txtana_fillipis_etal_IOC_2016.pdf.txtExtracted texttext/plain14494https://www.arca.fiocruz.br/bitstream/icict/15791/3/ana_fillipis_etal_IOC_2016.pdf.txtb06047330fdc03219f52a9436ccedc0aMD53icict/157912022-06-24 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dc.title.pt_BR.fl_str_mv Fatal encephalitis associated with Zika virus infection in an adult
title Fatal encephalitis associated with Zika virus infection in an adult
spellingShingle Fatal encephalitis associated with Zika virus infection in an adult
Soares, Cristiane N.
Zika virus
Encefalite
Manifestações neurológicas
Zika virus
Encephalitis
Neurological manifestations
title_short Fatal encephalitis associated with Zika virus infection in an adult
title_full Fatal encephalitis associated with Zika virus infection in an adult
title_fullStr Fatal encephalitis associated with Zika virus infection in an adult
title_full_unstemmed Fatal encephalitis associated with Zika virus infection in an adult
title_sort Fatal encephalitis associated with Zika virus infection in an adult
author Soares, Cristiane N.
author_facet Soares, Cristiane N.
Brasil, Patrícia
Carrera, Raquel Medialdea
Sequeira, Patricia
Filippis, Ana Maria Bispo de
Borges, Vitor A.
Theophilo, Fernando
Ellul, Mark A.
Solomon, Tom
author_role author
author2 Brasil, Patrícia
Carrera, Raquel Medialdea
Sequeira, Patricia
Filippis, Ana Maria Bispo de
Borges, Vitor A.
Theophilo, Fernando
Ellul, Mark A.
Solomon, Tom
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Cristiane N.
Brasil, Patrícia
Carrera, Raquel Medialdea
Sequeira, Patricia
Filippis, Ana Maria Bispo de
Borges, Vitor A.
Theophilo, Fernando
Ellul, Mark A.
Solomon, Tom
dc.subject.other.pt_BR.fl_str_mv Zika virus
Encefalite
Manifestações neurológicas
topic Zika virus
Encefalite
Manifestações neurológicas
Zika virus
Encephalitis
Neurological manifestations
dc.subject.en.pt_BR.fl_str_mv Zika virus
Encephalitis
Neurological manifestations
description Hospital Federal dos Servidores do Estado. Serviço de Neurologia. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-09-14T15:16:45Z
dc.date.available.fl_str_mv 2016-09-14T15:16:45Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, Cristiane N. et al. Fatal encephalitis associated with Zika virus infection in an adult. Journal of Clinical Virology, v.83, p.63-65, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15791
dc.identifier.issn.pt_BR.fl_str_mv 1386-6532
dc.identifier.doi.none.fl_str_mv 10.1016/j.jcv.2016.08.297
identifier_str_mv SOARES, Cristiane N. et al. Fatal encephalitis associated with Zika virus infection in an adult. Journal of Clinical Virology, v.83, p.63-65, 2016.
1386-6532
10.1016/j.jcv.2016.08.297
url https://www.arca.fiocruz.br/handle/icict/15791
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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