Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/255556 |
Resumo: | Background: Encephalitis is an inflammation of the cerebral parenchyma manifested by acute symptoms such as fever, headaches, and other neurological disorders. Its etiology is mostly viral, with herpes simplex virus being a frequent etiological agent in children. The development of neurological sequelae is a serious outcome associated with this infection. Objective: To assess the general prevalence and types of neurological sequelae in children after a case of acute viral encephalitis caused by HSV. Methods: This systematic review and meta-analysis was developed following the PRISMA guidelines. The literature search was carried out in the MEDLINE, Embase, SciELO, LILACS, Cochrane, CINAHL, PsycINFO, and Web of Science databases. Studies were included of children with confirmed HSV infection and that presented a description of neurological sequelae associated with that infection. For the meta-analysis of general prevalence and of the types of neurological sequelae a random effects model was used. Results: Of the 2827 articles chosen in the initial search, nine studies were included in the systematic review and meta-analysis. The general prevalence of neurological sequelae was 50.7% (95% CI 39.2–62.2). The most frequent sequelae were related to mental disability, with a 42.1% prevalence (95% CI 30–55.2); on the other hand, the least frequent sequelae were those related with visual impairment, with a 5.9% prevalence (95% CI 2.2–14.6). The included studies presented regular quality and substantial heterogeneity. Conclusion: Even with antiviral therapy, half of patients will develop some type of disability. |
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Rocha, Natalie DuranMoura, Sara Kvitko deSilva, Gabriel Aude Bueno daMattiello, RitaSato, Douglas Kazutoshi2023-03-10T03:27:02Z20231471-2334http://hdl.handle.net/10183/255556001161855Background: Encephalitis is an inflammation of the cerebral parenchyma manifested by acute symptoms such as fever, headaches, and other neurological disorders. Its etiology is mostly viral, with herpes simplex virus being a frequent etiological agent in children. The development of neurological sequelae is a serious outcome associated with this infection. Objective: To assess the general prevalence and types of neurological sequelae in children after a case of acute viral encephalitis caused by HSV. Methods: This systematic review and meta-analysis was developed following the PRISMA guidelines. The literature search was carried out in the MEDLINE, Embase, SciELO, LILACS, Cochrane, CINAHL, PsycINFO, and Web of Science databases. Studies were included of children with confirmed HSV infection and that presented a description of neurological sequelae associated with that infection. For the meta-analysis of general prevalence and of the types of neurological sequelae a random effects model was used. Results: Of the 2827 articles chosen in the initial search, nine studies were included in the systematic review and meta-analysis. The general prevalence of neurological sequelae was 50.7% (95% CI 39.2–62.2). The most frequent sequelae were related to mental disability, with a 42.1% prevalence (95% CI 30–55.2); on the other hand, the least frequent sequelae were those related with visual impairment, with a 5.9% prevalence (95% CI 2.2–14.6). The included studies presented regular quality and substantial heterogeneity. Conclusion: Even with antiviral therapy, half of patients will develop some type of disability.application/pdfengBMC infectious diseases. London. Vol. 23 (2023), 55, 20 p.EncefaliteSimplexvirusManifestações neurológicasCriançaAdolescenteEncephalitisHerpes simplex virusNeurological manifestationsChildren and adolescentsNeurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161855.pdf.txt001161855.pdf.txtExtracted Texttext/plain55896http://www.lume.ufrgs.br/bitstream/10183/255556/3/001161855.pdf.txt161c833e046fed4a3064c6f37280653fMD53001161855-02.pdf.txt001161855-02.pdf.txtExtracted Texttext/plain16923http://www.lume.ufrgs.br/bitstream/10183/255556/4/001161855-02.pdf.txt0098229f9a853f054df7699ecae2bde1MD54ORIGINAL001161855.pdfTexto completo (inglês)application/pdf1641805http://www.lume.ufrgs.br/bitstream/10183/255556/1/001161855.pdf98d8eea1f0f4463340f1449b7069b411MD51001161855-02.pdfMaterial suplementarapplication/pdf42753http://www.lume.ufrgs.br/bitstream/10183/255556/2/001161855-02.pdf40fc2c5fc986b40a21a15b883e49bea4MD5210183/2555562023-03-11 03:30:57.062245oai:www.lume.ufrgs.br:10183/255556Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-11T06:30:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
title |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
spellingShingle |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis Rocha, Natalie Duran Encefalite Simplexvirus Manifestações neurológicas Criança Adolescente Encephalitis Herpes simplex virus Neurological manifestations Children and adolescents |
title_short |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
title_full |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
title_fullStr |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
title_full_unstemmed |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
title_sort |
Neurological sequelae after encephalitis associated with herpes simplex virus in children : systematic review and meta-analysis |
author |
Rocha, Natalie Duran |
author_facet |
Rocha, Natalie Duran Moura, Sara Kvitko de Silva, Gabriel Aude Bueno da Mattiello, Rita Sato, Douglas Kazutoshi |
author_role |
author |
author2 |
Moura, Sara Kvitko de Silva, Gabriel Aude Bueno da Mattiello, Rita Sato, Douglas Kazutoshi |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rocha, Natalie Duran Moura, Sara Kvitko de Silva, Gabriel Aude Bueno da Mattiello, Rita Sato, Douglas Kazutoshi |
dc.subject.por.fl_str_mv |
Encefalite Simplexvirus Manifestações neurológicas Criança Adolescente |
topic |
Encefalite Simplexvirus Manifestações neurológicas Criança Adolescente Encephalitis Herpes simplex virus Neurological manifestations Children and adolescents |
dc.subject.eng.fl_str_mv |
Encephalitis Herpes simplex virus Neurological manifestations Children and adolescents |
description |
Background: Encephalitis is an inflammation of the cerebral parenchyma manifested by acute symptoms such as fever, headaches, and other neurological disorders. Its etiology is mostly viral, with herpes simplex virus being a frequent etiological agent in children. The development of neurological sequelae is a serious outcome associated with this infection. Objective: To assess the general prevalence and types of neurological sequelae in children after a case of acute viral encephalitis caused by HSV. Methods: This systematic review and meta-analysis was developed following the PRISMA guidelines. The literature search was carried out in the MEDLINE, Embase, SciELO, LILACS, Cochrane, CINAHL, PsycINFO, and Web of Science databases. Studies were included of children with confirmed HSV infection and that presented a description of neurological sequelae associated with that infection. For the meta-analysis of general prevalence and of the types of neurological sequelae a random effects model was used. Results: Of the 2827 articles chosen in the initial search, nine studies were included in the systematic review and meta-analysis. The general prevalence of neurological sequelae was 50.7% (95% CI 39.2–62.2). The most frequent sequelae were related to mental disability, with a 42.1% prevalence (95% CI 30–55.2); on the other hand, the least frequent sequelae were those related with visual impairment, with a 5.9% prevalence (95% CI 2.2–14.6). The included studies presented regular quality and substantial heterogeneity. Conclusion: Even with antiviral therapy, half of patients will develop some type of disability. |
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2023 |
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BMC infectious diseases. London. Vol. 23 (2023), 55, 20 p. |
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