Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19484 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil. |
id |
CRUZ_d247c4626fd140357e20d9bcef2a2b75 |
---|---|
oai_identifier_str |
oai:www.arca.fiocruz.br:icict/19484 |
network_acronym_str |
CRUZ |
network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
repository_id_str |
2135 |
spelling |
Santos, Fred Luciano NevesCeledon, Paola Alejandra FioraniZanchin, Nilson Ivo ToninSouza, Wayner Vieira deSilva, Edimilson Domingos daFoti, LeonardoKrieger, Marco AurélioGomes, Yara de Miranda2017-06-22T12:55:35Z2017-06-22T12:55:35Z2017SANTOS, Fred Luciano Neves et al. Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease – a Phase II study. PLOS Neglected Tropical Diseases, v. 11, n. 3, p. 1-20, Mar. 2017.1935-2735https://www.arca.fiocruz.br/handle/icict/1948410.1371/journal.pntd.0005433engDoença de ChagasDiagnósticoTestes SorológicosAnticorpos, protozoários / sangueAntígenos, protozoários / imunologiaDoença de Chagas / diagnósticoProteínas Recombinantes / imunologiaTrypanosoma cruzi / imunologiaAccuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil.Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brazil.Molecular Biology Institute of Paraná. Curitiba, PR, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil / Molecular Biology Institute of Paraná. Curitiba, PR, Brazil / Fundação Oswaldo Cruz. Instituto Carlos Chagas Institute. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil.The performance of current serologic tests for diagnosing chronic Chagas disease (CD) is highly variable. The search for new diagnostic markers has been a constant challenge for improving accuracy and reducing the number of inconclusive results.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19484/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL28273127 2017 san-acc.oa.pdf28273127 2017 san-acc.oa.pdfapplication/pdf5179215https://www.arca.fiocruz.br/bitstream/icict/19484/2/28273127%202017%20san-acc.oa.pdf12005c4a0c8fd5d5f9e1ed44052231f9MD52TEXT28273127 2017 san-acc.oa.pdf.txt28273127 2017 san-acc.oa.pdf.txtExtracted texttext/plain62334https://www.arca.fiocruz.br/bitstream/icict/19484/3/28273127%202017%20san-acc.oa.pdf.txt275eeb9cd281e6c0e3d342ec8be6d63cMD53icict/194842023-09-14 15:29:06.805oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-14T18:29:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
title |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
spellingShingle |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study Santos, Fred Luciano Neves Doença de Chagas Diagnóstico Testes Sorológicos Anticorpos, protozoários / sangue Antígenos, protozoários / imunologia Doença de Chagas / diagnóstico Proteínas Recombinantes / imunologia Trypanosoma cruzi / imunologia |
title_short |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
title_full |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
title_fullStr |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
title_full_unstemmed |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
title_sort |
Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease - a Phase II study |
author |
Santos, Fred Luciano Neves |
author_facet |
Santos, Fred Luciano Neves Celedon, Paola Alejandra Fiorani Zanchin, Nilson Ivo Tonin Souza, Wayner Vieira de Silva, Edimilson Domingos da Foti, Leonardo Krieger, Marco Aurélio Gomes, Yara de Miranda |
author_role |
author |
author2 |
Celedon, Paola Alejandra Fiorani Zanchin, Nilson Ivo Tonin Souza, Wayner Vieira de Silva, Edimilson Domingos da Foti, Leonardo Krieger, Marco Aurélio Gomes, Yara de Miranda |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Fred Luciano Neves Celedon, Paola Alejandra Fiorani Zanchin, Nilson Ivo Tonin Souza, Wayner Vieira de Silva, Edimilson Domingos da Foti, Leonardo Krieger, Marco Aurélio Gomes, Yara de Miranda |
dc.subject.other.none.fl_str_mv |
Doença de Chagas Diagnóstico Testes Sorológicos |
topic |
Doença de Chagas Diagnóstico Testes Sorológicos Anticorpos, protozoários / sangue Antígenos, protozoários / imunologia Doença de Chagas / diagnóstico Proteínas Recombinantes / imunologia Trypanosoma cruzi / imunologia |
dc.subject.decs.none.fl_str_mv |
Anticorpos, protozoários / sangue Antígenos, protozoários / imunologia Doença de Chagas / diagnóstico Proteínas Recombinantes / imunologia Trypanosoma cruzi / imunologia |
description |
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Chagas Disease Integrated Program. Rio de Janeiro, RJ, Brazil. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-06-22T12:55:35Z |
dc.date.available.fl_str_mv |
2017-06-22T12:55:35Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Fred Luciano Neves et al. Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease – a Phase II study. PLOS Neglected Tropical Diseases, v. 11, n. 3, p. 1-20, Mar. 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19484 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2735 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1371/journal.pntd.0005433 |
identifier_str_mv |
SANTOS, Fred Luciano Neves et al. Accuracy of chimeric proteins in the serological diagnosis of chronic chagas disease – a Phase II study. PLOS Neglected Tropical Diseases, v. 11, n. 3, p. 1-20, Mar. 2017. 1935-2735 10.1371/journal.pntd.0005433 |
url |
https://www.arca.fiocruz.br/handle/icict/19484 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/19484/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/19484/2/28273127%202017%20san-acc.oa.pdf https://www.arca.fiocruz.br/bitstream/icict/19484/3/28273127%202017%20san-acc.oa.pdf.txt |
bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 12005c4a0c8fd5d5f9e1ed44052231f9 275eeb9cd281e6c0e3d342ec8be6d63c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1794075653898764288 |