Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51137 |
Resumo: | This work was supported by grants from Fiocruz/INOVA COVID-19 (VPPCB-005-FIO-20), Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and the MercoSur Fund for Structural Convergence (Focem/Mercosur). It was developed in the frameworks of the Brazilian National Institute of Science and Technology on Neuroimmunomodulation and the Rio de Janeiro Research Network on Neuroinflammation. This article is dedicated to Juliana de Meis, a young researcher in the Laboratory on Thymus Research (FIOCRUZ, Rio de Janeiro), who passed away on July 16th due to COVID-19. |
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Arcanjo, AngélicaPinto, Kamila GuimarãesLogullo, JorgeteLeite, Paulo Emílio CorrêaMenezes, Camilla Cristie BarretoLima, Leonardo Freire deLima, Israel DinizDecoté-Ricardo, DeboraSilva, Rodrigo Nunes Rodrigues daLima, Celio Geraldo Freire deFilardy, Alessandra AlmeidaLima Junior, Josué da CostaBertho, Alvaro LuizLuca, Paula Mello DeGranjeiro, José MauroBarroso, Shana Priscila CoutinhoSilva, Fátima Conceição-Savino, WilsonMorrot, Alexandre2022-02-10T17:31:50Z2022-02-10T17:31:50Z2021ARCANJO, Angelica et al. Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection. The Journal of Infectious Diseases, p. 1-30, 2021.0022-1899https://www.arca.fiocruz.br/handle/icict/5113710.1093/infdis/jiab425This work was supported by grants from Fiocruz/INOVA COVID-19 (VPPCB-005-FIO-20), Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and the MercoSur Fund for Structural Convergence (Focem/Mercosur). It was developed in the frameworks of the Brazilian National Institute of Science and Technology on Neuroimmunomodulation and the Rio de Janeiro Research Network on Neuroinflammation. This article is dedicated to Juliana de Meis, a young researcher in the Laboratory on Thymus Research (FIOCRUZ, Rio de Janeiro), who passed away on July 16th due to COVID-19.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Qualidade e Tecnologia de Metrologia. Diretório de Metrologia Aplicada às Ciências da Vida – Dimav. Duque de Caxias, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Biomanguinhos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Qualidade e Tecnologia de Metrologia. Diretório de Metrologia Aplicada às Ciências da Vida – Dimav. Duque de Caxias, RJ, Brasil / Universidade Federal Fluminense. Escola de Odontologia. Niterói, RJ, Brasil.Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisa do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.COVID-19 can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm. We herein report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines. Our results show abnormal cytokine levels upon T cell stimulation, in a non-polarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28-CD57+ cells. Interestingly, we demonstrated for the first time an increased frequency of CD3+CD4+CD28-CD57+ T cells with expression of programmed death 1 (PD-1), one of the hallmarks of T cell exhaustion. These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T cell compartment and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events.engOxford University Press for the Infectious Diseases SocietyCOVID-19SARS-CoV-2 coronavirusImunopatologiaCélulas T esgotadas/senescentesCOVID-19SARS-CoV-2 coronavirusImmunopathologyExhausted/senescent T cellsCritically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| title |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| spellingShingle |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection Arcanjo, Angélica COVID-19 SARS-CoV-2 coronavirus Imunopatologia Células T esgotadas/senescentes COVID-19 SARS-CoV-2 coronavirus Immunopathology Exhausted/senescent T cells |
| title_short |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| title_full |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| title_fullStr |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| title_full_unstemmed |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| title_sort |
Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection |
| author |
Arcanjo, Angélica |
| author_facet |
Arcanjo, Angélica Pinto, Kamila Guimarães Logullo, Jorgete Leite, Paulo Emílio Corrêa Menezes, Camilla Cristie Barreto Lima, Leonardo Freire de Lima, Israel Diniz Decoté-Ricardo, Debora Silva, Rodrigo Nunes Rodrigues da Lima, Celio Geraldo Freire de Filardy, Alessandra Almeida Lima Junior, Josué da Costa Bertho, Alvaro Luiz Luca, Paula Mello De Granjeiro, José Mauro Barroso, Shana Priscila Coutinho Silva, Fátima Conceição- Savino, Wilson Morrot, Alexandre |
| author_role |
author |
| author2 |
Pinto, Kamila Guimarães Logullo, Jorgete Leite, Paulo Emílio Corrêa Menezes, Camilla Cristie Barreto Lima, Leonardo Freire de Lima, Israel Diniz Decoté-Ricardo, Debora Silva, Rodrigo Nunes Rodrigues da Lima, Celio Geraldo Freire de Filardy, Alessandra Almeida Lima Junior, Josué da Costa Bertho, Alvaro Luiz Luca, Paula Mello De Granjeiro, José Mauro Barroso, Shana Priscila Coutinho Silva, Fátima Conceição- Savino, Wilson Morrot, Alexandre |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Arcanjo, Angélica Pinto, Kamila Guimarães Logullo, Jorgete Leite, Paulo Emílio Corrêa Menezes, Camilla Cristie Barreto Lima, Leonardo Freire de Lima, Israel Diniz Decoté-Ricardo, Debora Silva, Rodrigo Nunes Rodrigues da Lima, Celio Geraldo Freire de Filardy, Alessandra Almeida Lima Junior, Josué da Costa Bertho, Alvaro Luiz Luca, Paula Mello De Granjeiro, José Mauro Barroso, Shana Priscila Coutinho Silva, Fátima Conceição- Savino, Wilson Morrot, Alexandre |
| dc.subject.other.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 coronavirus Imunopatologia Células T esgotadas/senescentes |
| topic |
COVID-19 SARS-CoV-2 coronavirus Imunopatologia Células T esgotadas/senescentes COVID-19 SARS-CoV-2 coronavirus Immunopathology Exhausted/senescent T cells |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 coronavirus Immunopathology Exhausted/senescent T cells |
| description |
This work was supported by grants from Fiocruz/INOVA COVID-19 (VPPCB-005-FIO-20), Conselho Nacional de Desenvolvimento Científico e Tecnológico do Brasil (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and the MercoSur Fund for Structural Convergence (Focem/Mercosur). It was developed in the frameworks of the Brazilian National Institute of Science and Technology on Neuroimmunomodulation and the Rio de Janeiro Research Network on Neuroinflammation. This article is dedicated to Juliana de Meis, a young researcher in the Laboratory on Thymus Research (FIOCRUZ, Rio de Janeiro), who passed away on July 16th due to COVID-19. |
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2021 |
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2021 |
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2022-02-10T17:31:50Z |
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2022-02-10T17:31:50Z |
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ARCANJO, Angelica et al. Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection. The Journal of Infectious Diseases, p. 1-30, 2021. |
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https://www.arca.fiocruz.br/handle/icict/51137 |
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0022-1899 |
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10.1093/infdis/jiab425 |
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ARCANJO, Angelica et al. Critically ill COVID-19 patients exhibit hyperactive cytokine responses associated with effector exhausted senescent T cells in acute infection. The Journal of Infectious Diseases, p. 1-30, 2021. 0022-1899 10.1093/infdis/jiab425 |
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https://www.arca.fiocruz.br/handle/icict/51137 |
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Oxford University Press for the Infectious Diseases Society |
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Oxford University Press for the Infectious Diseases Society |
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