Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection

Detalhes bibliográficos
Autor(a) principal: Arcanjo, Angélica
Data de Publicação: 2021
Outros Autores: Pinto, Kamila Guimarães, Logullo, Jorgete, Leite, Paulo Emílio Corrêa, Menezes, Camilla Cristie Barreto, Lima, Leonardo Freire de, Lima, Israel Diniz, Decoté-Ricardo, Debora, Silva, Rodrigo Nunes Rodrigues da, Lima, Celio Geraldo Freire de, Filardy, Alessandra Almeida, Lima Junior, Josué da Costa, Bertho, Álvaro Luiz, Luca, Paula Mello de, Granjeiro, José Mauro, Barroso, Shana Priscila Coutinho, Silva, Fátima Conceição, Savino, Wilson, Morrot, Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50800
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
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spelling Arcanjo, AngélicaPinto, Kamila GuimarãesLogullo, JorgeteLeite, Paulo Emílio CorrêaMenezes, Camilla Cristie BarretoLima, Leonardo Freire deLima, Israel DinizDecoté-Ricardo, DeboraSilva, Rodrigo Nunes Rodrigues daLima, Celio Geraldo Freire deFilardy, Alessandra AlmeidaLima Junior, Josué da CostaBertho, Álvaro LuizLuca, Paula Mello deGranjeiro, José MauroBarroso, Shana Priscila CoutinhoSilva, Fátima ConceiçãoSavino, WilsonMorrot, Alexandre2022-01-18T18:08:21Z2022-01-18T18:08:21Z2021ARCANJO, Angélica et al. Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection. The Journal of Infectious Diseases, v. 224, p. 1672-1683, Aug. 2021.1757-6512https://www.arca.fiocruz.br/handle/icict/5080010.1093/infdis/jiab425engOxford University PressCOVID-19SARS-CoV-2ImunopatologiaCélulas T esgotadas/senescentesCOVID-19Exhausted/senescent T cellsimmunopathologySARS-CoV-2Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Qualidade e Tecnologia de Metrologia. Diretório de Metrologia Aplicada às Ciências da Vida. Duque de Caxias, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Biomanguinhos. Laboratório de Tecnologia de Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Qualidade e Tecnologia de Metrologia. Diretório de Metrologia Aplicada às Ciências da Vida. Duque de Caxias, RJ, Brasil / Universidade Federal Fluminense. Escola de Odontologia. Niterói, RJ, Brasil.Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisa Biomédica. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional em Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisas do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Laboratório de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rede de Pesquisas do Rio de Janeiro em Neuroinflamação. Rio de Janeiro, RJ, Brasil.Background. Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm. Methods. In this study, we report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines. Results. Our results show abnormal cytokine levels upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28−CD57+ cells. Of note, we demonstrated for the first time an increased frequency of CD3+CD4+CD28−CD57+ T cells with expression of programmed death 1, one of the hallmarks of T-cell exhaustion. Conclusions. These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T-cell compartment, and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50800/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_AlexandreMorrot_etal_IOC_2021.pdfWilsonSavino_AlexandreMorrot_etal_IOC_2021.pdfapplication/pdf3354321https://www.arca.fiocruz.br/bitstream/icict/50800/2/WilsonSavino_AlexandreMorrot_etal_IOC_2021.pdfca97e342f83fe8adafcd62fa79cde2dcMD52icict/508002022-06-24 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dc.title.pt_BR.fl_str_mv Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
title Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
spellingShingle Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
Arcanjo, Angélica
COVID-19
SARS-CoV-2
Imunopatologia
Células T esgotadas/senescentes
COVID-19
Exhausted/senescent T cells
immunopathology
SARS-CoV-2
title_short Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
title_full Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
title_fullStr Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
title_full_unstemmed Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
title_sort Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection
author Arcanjo, Angélica
author_facet Arcanjo, Angélica
Pinto, Kamila Guimarães
Logullo, Jorgete
Leite, Paulo Emílio Corrêa
Menezes, Camilla Cristie Barreto
Lima, Leonardo Freire de
Lima, Israel Diniz
Decoté-Ricardo, Debora
Silva, Rodrigo Nunes Rodrigues da
Lima, Celio Geraldo Freire de
Filardy, Alessandra Almeida
Lima Junior, Josué da Costa
Bertho, Álvaro Luiz
Luca, Paula Mello de
Granjeiro, José Mauro
Barroso, Shana Priscila Coutinho
Silva, Fátima Conceição
Savino, Wilson
Morrot, Alexandre
author_role author
author2 Pinto, Kamila Guimarães
Logullo, Jorgete
Leite, Paulo Emílio Corrêa
Menezes, Camilla Cristie Barreto
Lima, Leonardo Freire de
Lima, Israel Diniz
Decoté-Ricardo, Debora
Silva, Rodrigo Nunes Rodrigues da
Lima, Celio Geraldo Freire de
Filardy, Alessandra Almeida
Lima Junior, Josué da Costa
Bertho, Álvaro Luiz
Luca, Paula Mello de
Granjeiro, José Mauro
Barroso, Shana Priscila Coutinho
Silva, Fátima Conceição
Savino, Wilson
Morrot, Alexandre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Arcanjo, Angélica
Pinto, Kamila Guimarães
Logullo, Jorgete
Leite, Paulo Emílio Corrêa
Menezes, Camilla Cristie Barreto
Lima, Leonardo Freire de
Lima, Israel Diniz
Decoté-Ricardo, Debora
Silva, Rodrigo Nunes Rodrigues da
Lima, Celio Geraldo Freire de
Filardy, Alessandra Almeida
Lima Junior, Josué da Costa
Bertho, Álvaro Luiz
Luca, Paula Mello de
Granjeiro, José Mauro
Barroso, Shana Priscila Coutinho
Silva, Fátima Conceição
Savino, Wilson
Morrot, Alexandre
dc.subject.other.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Imunopatologia
Células T esgotadas/senescentes
topic COVID-19
SARS-CoV-2
Imunopatologia
Células T esgotadas/senescentes
COVID-19
Exhausted/senescent T cells
immunopathology
SARS-CoV-2
dc.subject.en.pt_BR.fl_str_mv COVID-19
Exhausted/senescent T cells
immunopathology
SARS-CoV-2
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-18T18:08:21Z
dc.date.available.fl_str_mv 2022-01-18T18:08:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ARCANJO, Angélica et al. Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection. The Journal of Infectious Diseases, v. 224, p. 1672-1683, Aug. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50800
dc.identifier.issn.pt_BR.fl_str_mv 1757-6512
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiab425
identifier_str_mv ARCANJO, Angélica et al. Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection. The Journal of Infectious Diseases, v. 224, p. 1672-1683, Aug. 2021.
1757-6512
10.1093/infdis/jiab425
url https://www.arca.fiocruz.br/handle/icict/50800
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50800/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50800/2/WilsonSavino_AlexandreMorrot_etal_IOC_2021.pdf
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