The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
| Main Author: | |
|---|---|
| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/54952 |
Summary: | Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil. |
| id |
CRUZ_e492668bab0fb44f72b589f30306b12f |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/54952 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Honorato, LaylaWitkin, Steven S.Correa, Maria Cássia MendesToscano, Ana Luiza Castro CondeLinhares, Iara MorenoPaula, Anderson Vicente dePaião, Heuder Gustavo OliveiraPaula, Vanessa Salete deLopes, Amanda de OliveiraLima, Silvia HelenaRaymundi, Vanessa de CássiaFerreira, Noely EvangelistaSilva Junior, Almir Ribeiro daAbrahim, Karim YaqubSilva, Paulo Henrique BrazTozetto-Mendoza, Tania Regina2022-10-01T16:16:21Z2022-10-01T16:16:21Z2022HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022.2298-858Xhttps://www.arca.fiocruz.br/handle/icict/5495210.3389/fmed.2021.809312engFrontiers in MedicineLinfócitos CD4+HIVSarcoma de KaposiSalivaTorque teno vírusAnelovírusCD4+ lymphocytesHIVKaposi’s SarcomaSalivaTorque teno virusAnellovirusThe Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil / Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Instituto de Infectologia Emílio Ribas. Hospital Dia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Ginecologia e Obstetrícia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Odontologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Introduction: Torque teno virus (TTV) is a non-pathogenic virus present in body fluids. Its titer in the circulation increases in association with immune suppression, such as in HIV-infected individuals.We evaluated if the TTV titer in saliva fromHIV-positive individuals undergoing antiretroviral therapy (ART) was related to the circulating CD4+ T lymphocyte concentration and the HIV titer. Methods: Saliva was collected from 276 asymptomatic individuals undergoing ART, and an additional 48 individuals positive for AIDS-associated Kaposi’s Sarcoma (AIDSKS). The salivary TTV titer was measured by gene amplification analysis. The circulating CD4+ T lymphocyte and HIV levels were obtained by chart review. Results: TTV was detectable in saliva from 80%of the asymptomatic subjects and 87% of those with AIDS-KS. In the asymptomatic group the median log10 TTV titer/ml was 3.3 in 200 males vs. 2.4 in 76 females (p < 0.0001). TTV titer/ml was 3.7 when HIV was acquired by intravenous drug usage, 3.2 when by sexual acquisition and 2.4 when blood transfusion acquired. The salivary TTV titer was inversely correlated with the circulating CD4+ T lymphocyte level (p < 0.0001) and positively correlated with the circulating HIV concentration (p = 0.0005). The median salivary TTV titer and circulating HIV titer were higher, and the CD4+ count was lower, in individuals positive for AIDS-KS than in the asymptomatic subjects (p < 0.0001).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54952/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVanessaPaula_LauraHonorato_etal_IOC_2022.pdfVanessaPaula_LauraHonorato_etal_IOC_2022.pdfapplication/pdf261752https://www.arca.fiocruz.br/bitstream/icict/54952/2/VanessaPaula_LauraHonorato_etal_IOC_2022.pdf646322b780cf5c6677e13683295da325MD52icict/549522023-09-04 11:30:14.41oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:30:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| title |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| spellingShingle |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy Honorato, Layla Linfócitos CD4+ HIV Sarcoma de Kaposi Saliva Torque teno vírus Anelovírus CD4+ lymphocytes HIV Kaposi’s Sarcoma Saliva Torque teno virus Anellovirus |
| title_short |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| title_full |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| title_fullStr |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| title_full_unstemmed |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| title_sort |
The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy |
| author |
Honorato, Layla |
| author_facet |
Honorato, Layla Witkin, Steven S. Correa, Maria Cássia Mendes Toscano, Ana Luiza Castro Conde Linhares, Iara Moreno Paula, Anderson Vicente de Paião, Heuder Gustavo Oliveira Paula, Vanessa Salete de Lopes, Amanda de Oliveira Lima, Silvia Helena Raymundi, Vanessa de Cássia Ferreira, Noely Evangelista Silva Junior, Almir Ribeiro da Abrahim, Karim Yaqub Silva, Paulo Henrique Braz Tozetto-Mendoza, Tania Regina |
| author_role |
author |
| author2 |
Witkin, Steven S. Correa, Maria Cássia Mendes Toscano, Ana Luiza Castro Conde Linhares, Iara Moreno Paula, Anderson Vicente de Paião, Heuder Gustavo Oliveira Paula, Vanessa Salete de Lopes, Amanda de Oliveira Lima, Silvia Helena Raymundi, Vanessa de Cássia Ferreira, Noely Evangelista Silva Junior, Almir Ribeiro da Abrahim, Karim Yaqub Silva, Paulo Henrique Braz Tozetto-Mendoza, Tania Regina |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Honorato, Layla Witkin, Steven S. Correa, Maria Cássia Mendes Toscano, Ana Luiza Castro Conde Linhares, Iara Moreno Paula, Anderson Vicente de Paião, Heuder Gustavo Oliveira Paula, Vanessa Salete de Lopes, Amanda de Oliveira Lima, Silvia Helena Raymundi, Vanessa de Cássia Ferreira, Noely Evangelista Silva Junior, Almir Ribeiro da Abrahim, Karim Yaqub Silva, Paulo Henrique Braz Tozetto-Mendoza, Tania Regina |
| dc.subject.other.en_US.fl_str_mv |
Linfócitos CD4+ HIV Sarcoma de Kaposi Saliva Torque teno vírus Anelovírus |
| topic |
Linfócitos CD4+ HIV Sarcoma de Kaposi Saliva Torque teno vírus Anelovírus CD4+ lymphocytes HIV Kaposi’s Sarcoma Saliva Torque teno virus Anellovirus |
| dc.subject.en.en_US.fl_str_mv |
CD4+ lymphocytes HIV Kaposi’s Sarcoma Saliva Torque teno virus Anellovirus |
| description |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil. |
| publishDate |
2022 |
| dc.date.accessioned.fl_str_mv |
2022-10-01T16:16:21Z |
| dc.date.available.fl_str_mv |
2022-10-01T16:16:21Z |
| dc.date.issued.fl_str_mv |
2022 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/54952 |
| dc.identifier.issn.en_US.fl_str_mv |
2298-858X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmed.2021.809312 |
| identifier_str_mv |
HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022. 2298-858X 10.3389/fmed.2021.809312 |
| url |
https://www.arca.fiocruz.br/handle/icict/54952 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers in Medicine |
| publisher.none.fl_str_mv |
Frontiers in Medicine |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/54952/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/54952/2/VanessaPaula_LauraHonorato_etal_IOC_2022.pdf |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 646322b780cf5c6677e13683295da325 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324703530582016 |