Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Mendes-Aguiar, Carolina de O.
Data de Publicação: 2021
Outros Autores: Lopes-Siqueira, Camilla, Pettito-Assis, Fabrício, Pereira-Oliveira, Márcia, Oliveira-Neto, Manoel Paes de, Pirmez, Claude, Cruz, Alda Maria da, Goto, Hiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47368
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil..
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spelling Mendes-Aguiar, Carolina de O.Lopes-Siqueira, CamillaPettito-Assis, FabrícioPereira-Oliveira, MárciaOliveira-Neto, Manoel Paes dePirmez, ClaudeCruz, Alda Maria daGoto, Hiro2021-05-25T19:48:15Z2021-05-25T19:48:15Z2021MENDES-AGUIAR, Carolina de O. et al. Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis. Journal of immunology research, n. 6657785, p. 1-7, 20212314-8861https://www.arca.fiocruz.br/handle/icict/4736810.1155/2021/6657785engHindawiDual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Disciplina de Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil.Background: Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of Leishmania (Leishmania) amazonensis with recombinant IGF-I induces accelerated lesion development. However, in human cutaneous leishmaniasis (CL) pathogenesis, it is more relevant to the persistent inflammatory process than progressive parasite proliferation. In this context, we aimed to investigate whether IGF-I was present in the CL lesions and if this factor may influence the lesions' development acting on parasite growth and/or on the inflammatory/healing process. Methodology. Fifty-one CL patients' skin lesion samples from endemic area of L. (Viannia) braziliensis infection were submitted to histopathological analysis and searched for Leishmania and IGF-I expression by immunohistochemistry. Results: In human CL lesions, IGF-I was observed preferentially in the late lesion (more than 90 days), and the percentage of positive area for IGF-I was positively correlated with duration of illness (r = 0.42, P < 0.05). IGF-I was highly expressed in the inflammatory infiltrate of CL lesions from patients evolving with good response to therapy (2.8% ± 2.1%; median = 2.1%; n = 18) than poor responders (1.3% ± 1.1%; median: 1.05%; n = 6; P < 0.05). Conclusions: It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. IGF-I was related to chronicity and good response to treatment. We may relate this finding to the efficient anti-inflammatory response and the known action of IGF-I in wound repair. The present data highlight the importance of searching nonspecific factors besides adaptive immune elements in the study of leishmaniasis' pathogenesis.LeishmaniasisInsulin-like growth factor (IGF-I)Cutaneous leishmaniasisInflammatory processinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/47368/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALDual_Manoel_Neto_etal_INI_2021.pdfDual_Manoel_Neto_etal_INI_2021.pdfapplication/pdf1401699https://www.arca.fiocruz.br/bitstream/icict/47368/2/Dual_Manoel_Neto_etal_INI_2021.pdf0107692c2dc9fbb5e8a10146d00b84ddMD52TEXTDual_Manoel_Neto_etal_INI_2021.pdf.txtDual_Manoel_Neto_etal_INI_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
title Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
spellingShingle Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
Mendes-Aguiar, Carolina de O.
Leishmaniasis
Insulin-like growth factor (IGF-I)
Cutaneous leishmaniasis
Inflammatory process
title_short Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
title_full Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
title_fullStr Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
title_full_unstemmed Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
title_sort Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
author Mendes-Aguiar, Carolina de O.
author_facet Mendes-Aguiar, Carolina de O.
Lopes-Siqueira, Camilla
Pettito-Assis, Fabrício
Pereira-Oliveira, Márcia
Oliveira-Neto, Manoel Paes de
Pirmez, Claude
Cruz, Alda Maria da
Goto, Hiro
author_role author
author2 Lopes-Siqueira, Camilla
Pettito-Assis, Fabrício
Pereira-Oliveira, Márcia
Oliveira-Neto, Manoel Paes de
Pirmez, Claude
Cruz, Alda Maria da
Goto, Hiro
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendes-Aguiar, Carolina de O.
Lopes-Siqueira, Camilla
Pettito-Assis, Fabrício
Pereira-Oliveira, Márcia
Oliveira-Neto, Manoel Paes de
Pirmez, Claude
Cruz, Alda Maria da
Goto, Hiro
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Insulin-like growth factor (IGF-I)
Cutaneous leishmaniasis
Inflammatory process
topic Leishmaniasis
Insulin-like growth factor (IGF-I)
Cutaneous leishmaniasis
Inflammatory process
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio Grande do Norte. Instituto de Medicina Tropical do Rio Grande do Norte. Natal, RN, Brasil..
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-05-25T19:48:15Z
dc.date.available.fl_str_mv 2021-05-25T19:48:15Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENDES-AGUIAR, Carolina de O. et al. Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis. Journal of immunology research, n. 6657785, p. 1-7, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47368
dc.identifier.issn.pt_BR.fl_str_mv 2314-8861
dc.identifier.doi.none.fl_str_mv 10.1155/2021/6657785
identifier_str_mv MENDES-AGUIAR, Carolina de O. et al. Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis. Journal of immunology research, n. 6657785, p. 1-7, 2021
2314-8861
10.1155/2021/6657785
url https://www.arca.fiocruz.br/handle/icict/47368
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/47368/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/47368/2/Dual_Manoel_Neto_etal_INI_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/47368/3/Dual_Manoel_Neto_etal_INI_2021.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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