Association between insulin-like growth factor-I levels and the disease progression and anemia in visceral leishmaniasis

• Autor(a) principal: Maciel, Bruna Leal Lima
• Data de Publicação: 2019
• Outros Autores: Pinho, Flaviane Alves de, Vendrame, Célia Maria Vieira, Silva, Lucilene dos Santos, Miyashiro, Samantha Ive, Jerônimo, Selma Maria Bezerra, Goto, Hiro
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/57712; http://dx.doi.org/10.4269/ajtmh.17-0982
• topic: Insulin-like growth factor-I; Visceral leishmaniasis; Anemia; Pathogenesis

We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine production