Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13536 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil |
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Silva, Ana Patrícia CarvalhoMacêdo, Auricélio AlvesCosta, Luciana FachiniRocha, Claudia EmanuelaGarcia, Luize N. N.Farias, Jade Raquel DiasGomes, Priscilla P. R.Teixeira, Gustavo C.Fonseca, Kessler W. J.Maia, Andréa R. F.Neves, Gabriela G.Romão, Everton de LimaSilva, Teane Milagres Augusto daMol, Juliana Pinto SilvaOliveira, Renata MontiAraújo, Márcio Sobreira SilvaNascimento, Ernane F.Martins Filho, Olindo AssisBrandão, Humberto de MelloPaixão, Tatiane Alves daSantos, Renato de Lima2016-04-05T16:56:01Z2016-04-05T16:56:01Z2015SILVA, Ana Patrícia Carvalho et al. Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. PLoS One, vol. 10, n. 8, p. e0136865, 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1353610.1371/journal.pone.0136865engPublic Library of ScienceEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilUniversidade Estadual do Maranhão. Departamento de Patologia. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilEmpresa Brasileira de Agropecuária. Juiz de Fora, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, BrasilThis study aimed to evaluate protection induced by the vaccine candidate B. ovis ΔabcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis ΔabcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis ΔabcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis ΔabcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams.Animal healthBrucellaATP-binding cassette transportersBrucellosis/Vaccinationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13536/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEncapsulated Brucella(...) Transporte.pdfEncapsulated Brucella(...) Transporte.pdfapplication/pdf3817674https://www.arca.fiocruz.br/bitstream/icict/13536/2/Encapsulated%20Brucella%28...%29%20Transporte.pdffc75361cde3ac21b6b485230614c7a04MD52TEXTEncapsulated Brucella(...) Transporte.pdf.txtEncapsulated Brucella(...) 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Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| title |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| spellingShingle |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. Silva, Ana Patrícia Carvalho Animal health Brucella ATP-binding cassette transporters Brucellosis/Vaccination |
| title_short |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| title_full |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| title_fullStr |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| title_full_unstemmed |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| title_sort |
Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. |
| author |
Silva, Ana Patrícia Carvalho |
| author_facet |
Silva, Ana Patrícia Carvalho Macêdo, Auricélio Alves Costa, Luciana Fachini Rocha, Claudia Emanuela Garcia, Luize N. N. Farias, Jade Raquel Dias Gomes, Priscilla P. R. Teixeira, Gustavo C. Fonseca, Kessler W. J. Maia, Andréa R. F. Neves, Gabriela G. Romão, Everton de Lima Silva, Teane Milagres Augusto da Mol, Juliana Pinto Silva Oliveira, Renata Monti Araújo, Márcio Sobreira Silva Nascimento, Ernane F. Martins Filho, Olindo Assis Brandão, Humberto de Mello Paixão, Tatiane Alves da Santos, Renato de Lima |
| author_role |
author |
| author2 |
Macêdo, Auricélio Alves Costa, Luciana Fachini Rocha, Claudia Emanuela Garcia, Luize N. N. Farias, Jade Raquel Dias Gomes, Priscilla P. R. Teixeira, Gustavo C. Fonseca, Kessler W. J. Maia, Andréa R. F. Neves, Gabriela G. Romão, Everton de Lima Silva, Teane Milagres Augusto da Mol, Juliana Pinto Silva Oliveira, Renata Monti Araújo, Márcio Sobreira Silva Nascimento, Ernane F. Martins Filho, Olindo Assis Brandão, Humberto de Mello Paixão, Tatiane Alves da Santos, Renato de Lima |
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author author author author author author author author author author author author author author author author author author author author |
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Silva, Ana Patrícia Carvalho Macêdo, Auricélio Alves Costa, Luciana Fachini Rocha, Claudia Emanuela Garcia, Luize N. N. Farias, Jade Raquel Dias Gomes, Priscilla P. R. Teixeira, Gustavo C. Fonseca, Kessler W. J. Maia, Andréa R. F. Neves, Gabriela G. Romão, Everton de Lima Silva, Teane Milagres Augusto da Mol, Juliana Pinto Silva Oliveira, Renata Monti Araújo, Márcio Sobreira Silva Nascimento, Ernane F. Martins Filho, Olindo Assis Brandão, Humberto de Mello Paixão, Tatiane Alves da Santos, Renato de Lima |
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Animal health Brucella ATP-binding cassette transporters Brucellosis/Vaccination |
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Animal health Brucella ATP-binding cassette transporters Brucellosis/Vaccination |
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Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil |
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2015 |
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2015 |
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2016-04-05T16:56:01Z |
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SILVA, Ana Patrícia Carvalho et al. Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. PLoS One, vol. 10, n. 8, p. e0136865, 2015. |
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https://www.arca.fiocruz.br/handle/icict/13536 |
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1932-6203 |
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10.1371/journal.pone.0136865 |
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SILVA, Ana Patrícia Carvalho et al. Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams. PLoS One, vol. 10, n. 8, p. e0136865, 2015. 1932-6203 10.1371/journal.pone.0136865 |
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