Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9370 |
Resumo: | Ghent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, Belgium |
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Vercruysse, JozefBehnke, Jerzy M.Albonico, MarcoAme, Shaali MakameAngebault, CécileBethony, Jeffrey MichaelEngels, DirkGuillard, BertrandHoa, Nguyen Thi VietKang, GagandeepKattula, DeepthiKotze, Andrew C.McCarthy, James S.Mekonnen, ZelekeMontresor, AntonioPeriago, Maria VictoriaSumo, LaurentineTchuenté, Louis-Albert TchuemThach, Dang Thi CamZeynudin, Ahmedlevecke, Bruno2015-01-12T13:11:38Z2015-01-12T13:11:38Z2011VERCRUYSSE, Jozef F et al. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic. PLOS NEGLECT TROP D 5(3): e948.1932-6203https://www.arca.fiocruz.br/handle/icict/937010.1371/journal.pntd.0000948engPublic Library of ScienceAssessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemicinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGhent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, BelgiumUniversity of Nottingham. School of Biology. Nottingham, United KingdomIvo de Carneri. Public Health Laboratory. Pemba Island, Zanzibar, TanzaniaIvo de Carneri. Public Health Laboratory. Pemba Island, Zanzibar, TanzaniaInstitut Pasteur in Cambodia. Clinical Pathology Unit. Phnom Penh, CambodiaFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilWorld Health Organization. Department of Neglected Tropical Diseases. Geneva, SwitzerlandInstitut Pasteur in Cambodia. Clinical Pathology Unit. Phnom Penh, CambodiaNational Institute for Malariology, Parasitology and Entomology. Hanoi, VietnamChristian Medical College. Department of Gastrointestinal Sciences. Vellore, IndiaChristian Medical College. Department of Gastrointestinal Sciences. Vellore, IndiaCommonwealth Scientific and Industrial Research Organisation. Division of Livestock Industries. Brisbane, AustraliaUniversity of Queensland. Queensland Institute for Medical Research. Herston, AustraliaJimma University. College of Public Health and Medical Sciences. Department of Medical Laboratory Sciences and Pathology. Jimma, EthiopiaWorld Health Organization. Department of Neglected Tropical Diseases. Geneva, SwitzerlandFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrazilUniversity of Yaoundé I. Faculty of Sciences. Centre for Schistosomiasis and Parasitology. CameroonUniversity of Yaoundé I. Faculty of Sciences. Centre for Schistosomiasis and Parasitology. CameroonNational Institute for Malariology, Parasitology and Entomology. Hanoi, VietnamJimma University. College of Public Health and Medical Sciences. Department of Medical Laboratory Sciences and Pathology. Jimma, EthiopiaGhent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, BelgiumBackground: The three major soil-transmitted helminths (STH) Ascaris lumbricoides, Trichuris trichiura andNecator americanus/Ancylostoma duodenale are among the most widespread parasites worldwide. Despite the global expansion of preventive anthelmintic treatment, standard operating procedures to monitor anthelmintic drug efficacy are lacking. The objective of this study, therefore, was to define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STH using a standardized protocol. Methodology/Principal Findings : Seven trials were undertaken among school children in Brazil, Cameroon, Cambodia, Ethiopia, India, Tanzania and Vietnam. Efficacy was assessed by the Cure Rate (CR) and the Fecal Egg Count Reduction (FECR) using the McMaster egg counting technique to determine fecal egg counts (FEC). Overall, the highest CRs were observed for A. lumbricoides (98.2%) followed by hookworms (87.8%) and T. trichiura (46.6%). There was considerable variation in the CR for the three parasites across trials (country), by age or the pre-intervention FEC (pre-treatment). The latter is probably the most important as it had a considerable effect on the CR of all three STH. Therapeutic efficacies, as reflected by the FECRs, were very high for A. lumbricoides (99.5%) and hookworms (94.8%) but significantly lower for T. trichiura (50.8%), and were affected to different extents among the 3 species by the pre-intervention FEC counts and trial (country), but not by sex or age. Conclusions/Significance: Our findings suggest that a FECR (based on arithmetic means) of >95% for A. lumbricoidesand >90% for hookworms should be the expected minimum in all future surveys, and that therapeutic efficacy below this level following a single dose of ALB should be viewed with concern in light of potential drug resistance. A standard threshold for efficacy against T. trichiura has yet to be established, as a single-dose of ALB is unlikely to be satisfactory for this parasite.Ascaris lumbricoidesDrug therapyHelminth infectionsParasitic diseasesTanzania Trichuriasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9370/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic.pdf. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic.pdfapplication/pdf319089https://www.arca.fiocruz.br/bitstream/icict/9370/2/.%20Assessment%20of%20the%20Anthelmintic%20Efficacy%20of%20Albendazole%20in%20School%20Children%20in%20Seven%20Countries%20Where%20Soil-Transmitted%20Helminths%20Are%20Endemic.pdfda4c25eb37b45fee3eeac55ce13143d1MD52TEXT. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic.pdf.txt. 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| dc.title.pt_BR.fl_str_mv |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| title |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| spellingShingle |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic Vercruysse, Jozef Ascaris lumbricoides Drug therapy Helminth infections Parasitic diseases Tanzania Trichuriasis |
| title_short |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| title_full |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| title_fullStr |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| title_full_unstemmed |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| title_sort |
Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic |
| author |
Vercruysse, Jozef |
| author_facet |
Vercruysse, Jozef Behnke, Jerzy M. Albonico, Marco Ame, Shaali Makame Angebault, Cécile Bethony, Jeffrey Michael Engels, Dirk Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Kotze, Andrew C. McCarthy, James S. Mekonnen, Zeleke Montresor, Antonio Periago, Maria Victoria Sumo, Laurentine Tchuenté, Louis-Albert Tchuem Thach, Dang Thi Cam Zeynudin, Ahmed levecke, Bruno |
| author_role |
author |
| author2 |
Behnke, Jerzy M. Albonico, Marco Ame, Shaali Makame Angebault, Cécile Bethony, Jeffrey Michael Engels, Dirk Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Kotze, Andrew C. McCarthy, James S. Mekonnen, Zeleke Montresor, Antonio Periago, Maria Victoria Sumo, Laurentine Tchuenté, Louis-Albert Tchuem Thach, Dang Thi Cam Zeynudin, Ahmed levecke, Bruno |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vercruysse, Jozef Behnke, Jerzy M. Albonico, Marco Ame, Shaali Makame Angebault, Cécile Bethony, Jeffrey Michael Engels, Dirk Guillard, Bertrand Hoa, Nguyen Thi Viet Kang, Gagandeep Kattula, Deepthi Kotze, Andrew C. McCarthy, James S. Mekonnen, Zeleke Montresor, Antonio Periago, Maria Victoria Sumo, Laurentine Tchuenté, Louis-Albert Tchuem Thach, Dang Thi Cam Zeynudin, Ahmed levecke, Bruno |
| dc.subject.en.pt_BR.fl_str_mv |
Ascaris lumbricoides Drug therapy Helminth infections Parasitic diseases Tanzania Trichuriasis |
| topic |
Ascaris lumbricoides Drug therapy Helminth infections Parasitic diseases Tanzania Trichuriasis |
| description |
Ghent University. Faculty of Veterinary Medicine. Department of Virology, Parasitology and Immunology. Merelbeke, Belgium |
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2011 |
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2011 |
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2015-01-12T13:11:38Z |
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2015-01-12T13:11:38Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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VERCRUYSSE, Jozef F et al. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic. PLOS NEGLECT TROP D 5(3): e948. |
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https://www.arca.fiocruz.br/handle/icict/9370 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0000948 |
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VERCRUYSSE, Jozef F et al. Assessment of the Anthelmintic Efficacy of Albendazole in School Children in Seven Countries Where Soil-Transmitted Helminths Are Endemic. PLOS NEGLECT TROP D 5(3): e948. 1932-6203 10.1371/journal.pntd.0000948 |
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Public Library of Science |
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Public Library of Science |
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