Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
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Publication Date: | 2020 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Pesquisa Veterinária Brasileira (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020000300210 |
Summary: | ABSTRACT: Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway. |
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Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomasDogscancerosteopontin expressionprognostic biomarkerscanine mammary carcinomasimmunohistochemistryepidermal growth factor receptorhuman epidermal growth factor receptor 2ABSTRACT: Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.Colégio Brasileiro de Patologia Animal - CBPA2020-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020000300210Pesquisa Veterinária Brasileira v.40 n.3 2020reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/1678-5150-pvb-6489info:eu-repo/semantics/openAccessMonteiro,Lidianne N.Salgado,Breno S.Oliveira,Deilson E.Rivera-Calderon,Luis G.Montoya-Flórez,Luis M.Sanctis,PaulaRocha,Noeme S.eng2020-05-27T00:00:00Zoai:scielo:S0100-736X2020000300210Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2020-05-27T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false |
dc.title.none.fl_str_mv |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
title |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
spellingShingle |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas Monteiro,Lidianne N. Dogs cancer osteopontin expression prognostic biomarkers canine mammary carcinomas immunohistochemistry epidermal growth factor receptor human epidermal growth factor receptor 2 |
title_short |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
title_full |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
title_fullStr |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
title_full_unstemmed |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
title_sort |
Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas |
author |
Monteiro,Lidianne N. |
author_facet |
Monteiro,Lidianne N. Salgado,Breno S. Oliveira,Deilson E. Rivera-Calderon,Luis G. Montoya-Flórez,Luis M. Sanctis,Paula Rocha,Noeme S. |
author_role |
author |
author2 |
Salgado,Breno S. Oliveira,Deilson E. Rivera-Calderon,Luis G. Montoya-Flórez,Luis M. Sanctis,Paula Rocha,Noeme S. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Monteiro,Lidianne N. Salgado,Breno S. Oliveira,Deilson E. Rivera-Calderon,Luis G. Montoya-Flórez,Luis M. Sanctis,Paula Rocha,Noeme S. |
dc.subject.por.fl_str_mv |
Dogs cancer osteopontin expression prognostic biomarkers canine mammary carcinomas immunohistochemistry epidermal growth factor receptor human epidermal growth factor receptor 2 |
topic |
Dogs cancer osteopontin expression prognostic biomarkers canine mammary carcinomas immunohistochemistry epidermal growth factor receptor human epidermal growth factor receptor 2 |
description |
ABSTRACT: Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020000300210 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020000300210 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-5150-pvb-6489 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPA |
dc.source.none.fl_str_mv |
Pesquisa Veterinária Brasileira v.40 n.3 2020 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
instname_str |
Colégio Brasileiro de Patologia Animal (CBPA) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
reponame_str |
Pesquisa Veterinária Brasileira (Online) |
collection |
Pesquisa Veterinária Brasileira (Online) |
repository.name.fl_str_mv |
Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA) |
repository.mail.fl_str_mv |
colegio@cbpa.org.br||pvb@pvb.com.br |
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1754122240267386880 |