Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas

Detalhes bibliográficos
Autor(a) principal: Monteiro, Lidianne N.
Data de Publicação: 2020
Outros Autores: Salgado, Breno S., Oliveira, Deilson E. [UNESP], Rivera-Calderon, Luis G., Montoya-Flórez, Luis M., Sanctis, Paula [UNESP], Rocha, Noeme S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-5150-PVB-6489
http://hdl.handle.net/11449/200786
Resumo: Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.
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spelling Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomasExpessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninosCancerCanine mammary carcinomasDogsEpidermal growth factor receptorHuman epidermal growth factor receptor 2ImmunohistochemistryOsteopontin expressionPrognostic biomarkersOsteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Consultoria Diagnóstica em Patologia Veterinária (CODIVET) Faculdade Multivix Campus Vitoria, Rua José Alves 135Departamento de Clinica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Maurício Corrêa s/nFaculdade de Medicina Veterinária Universidade Federal do Espírito Santo (UFES), Av. Fernando Ferrari 514Faculdade de Medicina Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Av. Prof. Mário Rubens Guimarães Montenegro s/nFacultad de Medicina Veterinaria Universidad Antonio Nariño Sede Popayan, Calle 53 #9-35Departamento de Clinica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Maurício Corrêa s/nFaculdade de Medicina Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Av. Prof. Mário Rubens Guimarães Montenegro s/nFAPESP: 2010/51596-2CNPq: 479178/2010-0Faculdade MultivixUniversidade Estadual Paulista (Unesp)Universidade Federal do Espírito Santo (UFES)Sede PopayanMonteiro, Lidianne N.Salgado, Breno S.Oliveira, Deilson E. [UNESP]Rivera-Calderon, Luis G.Montoya-Flórez, Luis M.Sanctis, Paula [UNESP]Rocha, Noeme S. [UNESP]2020-12-12T02:16:01Z2020-12-12T02:16:01Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article210-219application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-6489Pesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.1678-51500100-736Xhttp://hdl.handle.net/11449/20078610.1590/1678-5150-PVB-6489S0100-736X20200003002102-s2.0-85088277890S0100-736X2020000300210.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-12-17T06:16:08Zoai:repositorio.unesp.br:11449/200786Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-17T06:16:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
Expessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninos
title Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
spellingShingle Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
Monteiro, Lidianne N.
Cancer
Canine mammary carcinomas
Dogs
Epidermal growth factor receptor
Human epidermal growth factor receptor 2
Immunohistochemistry
Osteopontin expression
Prognostic biomarkers
title_short Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
title_full Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
title_fullStr Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
title_full_unstemmed Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
title_sort Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas
author Monteiro, Lidianne N.
author_facet Monteiro, Lidianne N.
Salgado, Breno S.
Oliveira, Deilson E. [UNESP]
Rivera-Calderon, Luis G.
Montoya-Flórez, Luis M.
Sanctis, Paula [UNESP]
Rocha, Noeme S. [UNESP]
author_role author
author2 Salgado, Breno S.
Oliveira, Deilson E. [UNESP]
Rivera-Calderon, Luis G.
Montoya-Flórez, Luis M.
Sanctis, Paula [UNESP]
Rocha, Noeme S. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade Multivix
Universidade Estadual Paulista (Unesp)
Universidade Federal do Espírito Santo (UFES)
Sede Popayan
dc.contributor.author.fl_str_mv Monteiro, Lidianne N.
Salgado, Breno S.
Oliveira, Deilson E. [UNESP]
Rivera-Calderon, Luis G.
Montoya-Flórez, Luis M.
Sanctis, Paula [UNESP]
Rocha, Noeme S. [UNESP]
dc.subject.por.fl_str_mv Cancer
Canine mammary carcinomas
Dogs
Epidermal growth factor receptor
Human epidermal growth factor receptor 2
Immunohistochemistry
Osteopontin expression
Prognostic biomarkers
topic Cancer
Canine mammary carcinomas
Dogs
Epidermal growth factor receptor
Human epidermal growth factor receptor 2
Immunohistochemistry
Osteopontin expression
Prognostic biomarkers
description Osteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:16:01Z
2020-12-12T02:16:01Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-5150-PVB-6489
Pesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.
1678-5150
0100-736X
http://hdl.handle.net/11449/200786
10.1590/1678-5150-PVB-6489
S0100-736X2020000300210
2-s2.0-85088277890
S0100-736X2020000300210.pdf
url http://dx.doi.org/10.1590/1678-5150-PVB-6489
http://hdl.handle.net/11449/200786
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.
1678-5150
0100-736X
10.1590/1678-5150-PVB-6489
S0100-736X2020000300210
2-s2.0-85088277890
S0100-736X2020000300210.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 210-219
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965311963758592

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