Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.

Detalhes bibliográficos
Autor(a) principal: NICIURA, S. C. M.
Data de Publicação: 2019
Outros Autores: TIZIOTO, P. C., MORAES, C. V., CRUVINEL, G. G., ALBUQUERQUE, A. C. A. de, SANTANA, R. C. M., CHAGAS, A. C. de S., ESTEVES, S. N., BENAVIDES, M. V., AMARANTE, A. F. T. do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456
https://doi.org/10.1186/s13071-019-3663-9
Resumo: Haemonchus contortus, a gastrointestinal nematode parasite of sheep, is mainly controlled by anthelmintics; the occurrence of anthelmintic resistance leads to treatment failures and increases economic burden. Because molecular mechanisms involved in drug resistance can be elucidated by genomic studies, an extreme quantitative trait locus (X-QTL) mapping approach was used to identify co-segregation of the resistance phenotype with genetic markers to detect the genome-wide variants associated with monepantel resistance in H. contortus.
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spelling Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.Anthelmintic resistanceGenome sequencingSheep gastrointestinal nematodesF2 mappingDrug resistanceHaemonchus contortus, a gastrointestinal nematode parasite of sheep, is mainly controlled by anthelmintics; the occurrence of anthelmintic resistance leads to treatment failures and increases economic burden. Because molecular mechanisms involved in drug resistance can be elucidated by genomic studies, an extreme quantitative trait locus (X-QTL) mapping approach was used to identify co-segregation of the resistance phenotype with genetic markers to detect the genome-wide variants associated with monepantel resistance in H. contortus.SIMONE CRISTINA MEO NICIURA, CPPSE; Polyana Cristine Tizioto, NGS Soluções Genômicas; Caroline Valério Moraes, UFSCar; Giovanna Gabrielle Cruvinel, UNICEP; Ana Cláudia Alexandre de Albuquerque, FMVZ-UNESP; RAUL COSTA MASCARENHAS SANTANA, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; Alessandro Francisco Talamini do Amarante, IBB-UNESP.NICIURA, S. C. M.TIZIOTO, P. C.MORAES, C. V.CRUVINEL, G. G.ALBUQUERQUE, A. C. A. deSANTANA, R. C. M.CHAGAS, A. C. de S.ESTEVES, S. N.BENAVIDES, M. V.AMARANTE, A. F. T. do2019-08-21T00:38:33Z2019-08-21T00:38:33Z2019-08-2020192019-10-10T11:11:11Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParasites Vectors, v.12, n.403, p.1-11, 2019.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456https://doi.org/10.1186/s13071-019-3663-9enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2019-08-21T00:38:40Zoai:www.alice.cnptia.embrapa.br:doc/1111456Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542019-08-21T00:38:40falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542019-08-21T00:38:40Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
title Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
spellingShingle Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
NICIURA, S. C. M.
Anthelmintic resistance
Genome sequencing
Sheep gastrointestinal nematodes
F2 mapping
Drug resistance
title_short Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
title_full Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
title_fullStr Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
title_full_unstemmed Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
title_sort Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
author NICIURA, S. C. M.
author_facet NICIURA, S. C. M.
TIZIOTO, P. C.
MORAES, C. V.
CRUVINEL, G. G.
ALBUQUERQUE, A. C. A. de
SANTANA, R. C. M.
CHAGAS, A. C. de S.
ESTEVES, S. N.
BENAVIDES, M. V.
AMARANTE, A. F. T. do
author_role author
author2 TIZIOTO, P. C.
MORAES, C. V.
CRUVINEL, G. G.
ALBUQUERQUE, A. C. A. de
SANTANA, R. C. M.
CHAGAS, A. C. de S.
ESTEVES, S. N.
BENAVIDES, M. V.
AMARANTE, A. F. T. do
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv SIMONE CRISTINA MEO NICIURA, CPPSE; Polyana Cristine Tizioto, NGS Soluções Genômicas; Caroline Valério Moraes, UFSCar; Giovanna Gabrielle Cruvinel, UNICEP; Ana Cláudia Alexandre de Albuquerque, FMVZ-UNESP; RAUL COSTA MASCARENHAS SANTANA, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; Alessandro Francisco Talamini do Amarante, IBB-UNESP.
dc.contributor.author.fl_str_mv NICIURA, S. C. M.
TIZIOTO, P. C.
MORAES, C. V.
CRUVINEL, G. G.
ALBUQUERQUE, A. C. A. de
SANTANA, R. C. M.
CHAGAS, A. C. de S.
ESTEVES, S. N.
BENAVIDES, M. V.
AMARANTE, A. F. T. do
dc.subject.por.fl_str_mv Anthelmintic resistance
Genome sequencing
Sheep gastrointestinal nematodes
F2 mapping
Drug resistance
topic Anthelmintic resistance
Genome sequencing
Sheep gastrointestinal nematodes
F2 mapping
Drug resistance
description Haemonchus contortus, a gastrointestinal nematode parasite of sheep, is mainly controlled by anthelmintics; the occurrence of anthelmintic resistance leads to treatment failures and increases economic burden. Because molecular mechanisms involved in drug resistance can be elucidated by genomic studies, an extreme quantitative trait locus (X-QTL) mapping approach was used to identify co-segregation of the resistance phenotype with genetic markers to detect the genome-wide variants associated with monepantel resistance in H. contortus.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-21T00:38:33Z
2019-08-21T00:38:33Z
2019-08-20
2019
2019-10-10T11:11:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Parasites Vectors, v.12, n.403, p.1-11, 2019.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456
https://doi.org/10.1186/s13071-019-3663-9
identifier_str_mv Parasites Vectors, v.12, n.403, p.1-11, 2019.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1111456
https://doi.org/10.1186/s13071-019-3663-9
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
collection Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
repository.mail.fl_str_mv cg-riaa@embrapa.br
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