Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus.
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
Texto Completo: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/940280 |
Resumo: | The increasing resistance of Rhipicephalus (Boophilus) microplus tick to commercial insecticides requires alternative methods for the control of this cattle plague. The enthomopathogenic fungus Beauveria felina produces destruxins in culture media, cyclic depsipeptides which display an array of biological activities. The present investigation aimed to evaluate the acaricide action of destruxins isolated from B. felina culture media on R. (B.) microplus engorged females. B. felina was grown in MF medium under 19 different growth conditions. HPLC-PDA analysis of chromatographic fractions obtained from the 19 different growth media extracts indicated the presence of destruxins in all lipophylic fractions. Such fractions were combined and subjected to separation by HPLC. Fractions containing distinct destruxins composition were tested against R. (B.) microplus. Two fractions, composed of destruxin Ed1 and pseudodestruxin B and/or pseudodestruxin C (fraction P1) as well as by hydroxyhomodestruxin B and/or destruxin D and/ or roseotoxin C (fraction P7), displayed 30% and 28.7% acaricidal efficacy, respectively. This activity profile in such low concentration is adequate to consider destruxins as potential leading compounds to be developed for tick biological control. |
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Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus.DestruxinsBeauveria felinaTick Rhipicephalus(Boophilus) microplusAlternative controlThe increasing resistance of Rhipicephalus (Boophilus) microplus tick to commercial insecticides requires alternative methods for the control of this cattle plague. The enthomopathogenic fungus Beauveria felina produces destruxins in culture media, cyclic depsipeptides which display an array of biological activities. The present investigation aimed to evaluate the acaricide action of destruxins isolated from B. felina culture media on R. (B.) microplus engorged females. B. felina was grown in MF medium under 19 different growth conditions. HPLC-PDA analysis of chromatographic fractions obtained from the 19 different growth media extracts indicated the presence of destruxins in all lipophylic fractions. Such fractions were combined and subjected to separation by HPLC. Fractions containing distinct destruxins composition were tested against R. (B.) microplus. Two fractions, composed of destruxin Ed1 and pseudodestruxin B and/or pseudodestruxin C (fraction P1) as well as by hydroxyhomodestruxin B and/or destruxin D and/ or roseotoxin C (fraction P7), displayed 30% and 28.7% acaricidal efficacy, respectively. This activity profile in such low concentration is adequate to consider destruxins as potential leading compounds to be developed for tick biological control.RAQUEL P. MORAIS-URANO, INSTITUTO DE QUÍMICA DA USP/SÃO CARLOS, SP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; ROBERTO G.S. BERLINCK, INSTITUTO DE QUIMICA DA USP/SÃO CARLOS, SP.MORAIS-URANO, R. P.CHAGAS, A. C. de S.BERLINCK, R. G. S.2023-02-17T17:01:43Z2023-02-17T17:01:43Z2012-11-222012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleExperimental Parasitology, v. 132, n. 3, p. 362-366, aug. 2012.http://www.alice.cnptia.embrapa.br/alice/handle/doc/94028010.1016/j.exppara.2012.08.011enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2023-02-17T17:01:43Zoai:www.alice.cnptia.embrapa.br:doc/940280Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542023-02-17T17:01:43falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542023-02-17T17:01:43Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false |
dc.title.none.fl_str_mv |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
title |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
spellingShingle |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. MORAIS-URANO, R. P. Destruxins Beauveria felina Tick Rhipicephalus (Boophilus) microplus Alternative control |
title_short |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
title_full |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
title_fullStr |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
title_full_unstemmed |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
title_sort |
Acaricidal action of destruxins produced by a marine-derived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus. |
author |
MORAIS-URANO, R. P. |
author_facet |
MORAIS-URANO, R. P. CHAGAS, A. C. de S. BERLINCK, R. G. S. |
author_role |
author |
author2 |
CHAGAS, A. C. de S. BERLINCK, R. G. S. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RAQUEL P. MORAIS-URANO, INSTITUTO DE QUÍMICA DA USP/SÃO CARLOS, SP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; ROBERTO G.S. BERLINCK, INSTITUTO DE QUIMICA DA USP/SÃO CARLOS, SP. |
dc.contributor.author.fl_str_mv |
MORAIS-URANO, R. P. CHAGAS, A. C. de S. BERLINCK, R. G. S. |
dc.subject.por.fl_str_mv |
Destruxins Beauveria felina Tick Rhipicephalus (Boophilus) microplus Alternative control |
topic |
Destruxins Beauveria felina Tick Rhipicephalus (Boophilus) microplus Alternative control |
description |
The increasing resistance of Rhipicephalus (Boophilus) microplus tick to commercial insecticides requires alternative methods for the control of this cattle plague. The enthomopathogenic fungus Beauveria felina produces destruxins in culture media, cyclic depsipeptides which display an array of biological activities. The present investigation aimed to evaluate the acaricide action of destruxins isolated from B. felina culture media on R. (B.) microplus engorged females. B. felina was grown in MF medium under 19 different growth conditions. HPLC-PDA analysis of chromatographic fractions obtained from the 19 different growth media extracts indicated the presence of destruxins in all lipophylic fractions. Such fractions were combined and subjected to separation by HPLC. Fractions containing distinct destruxins composition were tested against R. (B.) microplus. Two fractions, composed of destruxin Ed1 and pseudodestruxin B and/or pseudodestruxin C (fraction P1) as well as by hydroxyhomodestruxin B and/or destruxin D and/ or roseotoxin C (fraction P7), displayed 30% and 28.7% acaricidal efficacy, respectively. This activity profile in such low concentration is adequate to consider destruxins as potential leading compounds to be developed for tick biological control. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-22 2012 2023-02-17T17:01:43Z 2023-02-17T17:01:43Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Experimental Parasitology, v. 132, n. 3, p. 362-366, aug. 2012. http://www.alice.cnptia.embrapa.br/alice/handle/doc/940280 10.1016/j.exppara.2012.08.011 |
identifier_str_mv |
Experimental Parasitology, v. 132, n. 3, p. 362-366, aug. 2012. 10.1016/j.exppara.2012.08.011 |
url |
http://www.alice.cnptia.embrapa.br/alice/handle/doc/940280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
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Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
instacron_str |
EMBRAPA |
institution |
EMBRAPA |
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Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
collection |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) |
repository.name.fl_str_mv |
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa) |
repository.mail.fl_str_mv |
cg-riaa@embrapa.br |
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1794503540037648384 |